Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721409 | 0.85 | ALOX5 (0.59) | ALOX5ESR2GFERPOLBGAA | |
| SCHEMBL8775893 | 0.84 | ALOX5 (0.57) | ALOX5ESR2GFERPOLBGAA | |
| SCHEMBL27765267 | 0.82 | ALOX5 (0.55) | ALOX5ESR2GFERPOLBGAA | |
| SCHEMBL27638952 | 0.79 | PKM (0.54) | HSD17B10MCL1CYP2C9CA12CA1 | |
| SCHEMBL27311317 | 0.79 | KDM4E (0.46) | POLBKMT2APTGS1CA12CA1 | |
| SCHEMBL6548544 | 0.78 | F10 (0.52) | BACE1LDHAPTGS1CYP2C9CA12 | |
| SCHEMBL48885 | 0.77 | CA2 (0.52) | PTGS1HSD17B10CYP2C9CA12CA1 | |
| SCHEMBL69153 | 0.76 | ALOX5 (1.00) | ALOX5ESR2GFERBACE1ESR1 | |
| SCHEMBL29629264 | 0.76 | ALOX5 (1.00) | ALOX5ESR2GFERBACE1ESR1 | |
| Hydrochloric Acid SCHEMBL6399557 | 0.75 | CA2 (0.50) | PTGS1HSD17B10CYP2C9CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7923446-B2 | 3-Methyl-2-[4'-(pyridin-3-ylmethoxymethyl)-biphenyl-4-sulfonylamino]-butyric acid; metalloproteinase inhibitors; arthritis, macular degeneration, graft versus host disease, cancer, osteoarthritis | WYETH LLC (US) | 2011-04-12 | — | — | US | disclosed |
| EP-1689380-A4 | METHOD FOR TREATING ADAMTS-5-ASSOCIATED DISEASE | WYETH CORP (US) | 2009-03-18 | — | — | EP | disclosed |
| US-20080311113-A1 | METHOD FOR TREATING ADAMTS-5-ASSOCIATED DISEASE | WYETH (US) | 2008-12-18 | — | — | US | disclosed |
| US-7390833-B2 | Method for treating ADAMTS-5-associated disease | WYETH (US) | 2008-06-24 | — | — | US | disclosed |
| CN-100381424-C | Biaryl sulfonamides and methods for using same | WYETH CORP (US) | 2008-04-16 | — | — | CN | disclosed |
| US-20070225327-A1 | Biaryl Sulfonamides and Methods for Using Same | WYETH (US) | 2007-09-27 | — | — | US | disclosed |
| US-7268135-B2 | Biaryl sulfonamides and methods for using same | WYETH (US) | 2007-09-11 | — | — | US | disclosed |
| EP-1689380-A2 | METHOD FOR TREATING ADAMTS-5-ASSOCIATED DISEASE | Wyeth (US) | 2006-08-16 | — | — | EP | disclosed |
| EP-1689716-A1 | BIARYL SULFONAMIDES AND METHODS FOR USING SAME | Wyeth (US) | 2006-08-16 | — | — | EP | disclosed |
| US-20060004066-A1 | Method for treating ADAMTS-5-associated disease | WYETH (US) | 2006-01-05 | — | — | US | disclosed |
| WO-2005060456-A2 | METHOD FOR TREATING ADAMTS-5-ASSOCIATE DISEASE | WYETH (US) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005061459-A1 | BIARYL SULFONAMIDES AND METHODS FOR USING SAME | WYETH (US) | 2005-07-07 | — | — | WO | disclosed |
| US-20050130973-A1 | Biaryl sulfonamides and methods for using same | WYETH (US) | 2005-06-16 | — | — | US | disclosed |
| CN-1623988-A | Biaryl sulfonamides and methods for using same | WYETH CORP (US) | 2005-06-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130973-A1 | Biaryl sulfonamides and methods for using same | STS, MMP3, AADAC | ALOX5 1118/4885ESR2 2164/4885GFER 390/4885 |
| US-20060004066-A1 | Method for treating ADAMTS-5-associated disease | ADAMTS5, ADAMTS1, ADAMTS4 | ALOX5 393/4885ESR2 3831/4885GFER 910/4885 |
| US-20080311113-A1 | METHOD FOR TREATING ADAMTS-5-ASSOCIATED DISEASE | ADAMTS5, ADAMTS1, ADAMTS4 | ALOX5 393/4885ESR2 3831/4885GFER 910/4885 |
| US-20070225327-A1 | Biaryl Sulfonamides and Methods for Using Same | STS, MMP3, AADAC | ALOX5 1118/4885ESR2 2164/4885GFER 390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.