Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.57 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL29009712 | 0.96 | LMNA (0.58) | LMNAKDM4EAPOBEC3AAPOBEC3GGAA | |
| SCHEMBL4749641 | 0.94 | LMNA (0.65) | LMNAKDM4EAPOBEC3AAPOBEC3GGAA | |
| SCHEMBL10014116 | 0.94 | LMNA (0.65) | LMNAKDM4EAPOBEC3AAPOBEC3GGAA | |
| SCHEMBL19809887 | 0.94 | LMNA (0.65) | LMNAKDM4EAPOBEC3AAPOBEC3GGAA | |
| SCHEMBL6421580 | 0.94 | LMNA (0.65) | LMNAKDM4EAPOBEC3AAPOBEC3GGAA | |
| SCHEMBL1618051 | 0.94 | LMNA (0.65) | LMNAKDM4EAPOBEC3AAPOBEC3GGAA | |
| SCHEMBL1617431 | 0.94 | LMNA (0.65) | LMNAKDM4EAPOBEC3AAPOBEC3GGAA | |
| SCHEMBL15144383 | 0.94 | LMNA (0.65) | LMNAKDM4EAPOBEC3AAPOBEC3GGAA | |
| SCHEMBL110177 | 0.94 | LMNA (0.65) | LMNAKDM4EAPOBEC3AAPOBEC3GGAA | |
| SCHEMBL14565715 | 0.94 | LMNA (0.65) | LMNAKDM4EAPOBEC3AAPOBEC3GGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 175 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240058243-A1 | A METHOD FOR FIGHTING MICROORGANISMS USING MENTHOL DERIVATIVES | SYMRISE AG (DE) | 2024-02-22 | — | — | US | claimed |
| EP-4259287-A1 | A METHOD FOR FIGHTING MICROORGANISMS USING MENTHOL DERIVATIVES | Symrise AG (DE) | 2023-10-18 | — | — | EP | claimed |
| EP-3081207-B1 | USE OF A LIPOSOME COMPOSITION | SYMRISE AG (DE) | 2022-09-21 | — | — | EP | claimed |
| WO-2022122144-A1 | A METHOD FOR FIGHTING MICROORGANISMS USING MENTHOL DERIVATIVES | SYMRISE AG (DE) | 2022-06-16 | — | — | WO | claimed |
| EP-3687311-A1 | AMIDES FOR GENERATING A TRIGEMINAL EFFECT | Symrise AG (DE) | 2020-08-05 | — | — | EP | claimed |
| EP-3142499-B1 | HOMOVANILLIC ACID ESTERS, IN PARTICULAR FOR ACHIEVING AN IMPRESSION OF HEAT AND/OR SPICINESS | SYMRISE AG (DE) | 2019-10-30 | — | — | EP | claimed |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2019-08-27 | — | — | US | claimed |
| WO-2016166038-A1 | WHITENING COMPOSITIONS | SYMRISE AG (DE) | 2016-10-20 | — | — | WO | claimed |
| EP-3081207-A1 | WHITENING COMPOSITIONS | Symrise AG (DE) | 2016-10-19 | — | — | EP | claimed |
| EP-4192614-B1 | PROCESS FOR THE PREPARATION OF MICROCAPSULES | SYMRISE AG (DE) | 2026-05-06 | — | — | EP | disclosed |
| EP-4725476-A2 | COMPOSITIONS FOR REDUCING SALTY TASTE AND USES THEREOF | Firmenich SA (CH) | 2026-04-15 | — | — | EP | disclosed |
| EP-4096714-B1 | COMPOSITIONS FOR REDUCING SALTY TASTE AND USES THEREOF | FIRMENICH & CIE (CH) | 2026-01-28 | — | — | EP | disclosed |
| US-20260014103-A1 | COMBINATION REMEDY | SYMRISE AG (DE) | 2026-01-15 | — | — | US | disclosed |
| US-20250387310-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | FIRMENICH INCORPORATED (US) | 2025-12-25 | — | — | US | disclosed |
| WO-2010149798-A2 | USE OF POLYOLS FOR ENHANCING THE COOLING EFFECT OF A COOLING SUBSTANCE AND COOLING MIXTURES HAVING AN ENHANCED COOLING EFFECT | SYMRISE AG (DE) | 2010-12-29 | — | — | WO | disclosed |
| US-20090054520-A1 | OXALIC ACID DERIVATIVES AND USE THEREOF AS PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS | SYMRISE GMBH & CO. KG (DE) | 2009-02-26 | — | — | US | disclosed |
| US-20080175800-A1 | USE OF SPECIFIC MENTHYL 3-OXOCARBOXYLIC ACID ESTERS AS PHYSIOLOGICALLY ACTIVE COOLING SUBSTANCES | SYMRISE GMBH & CO. KG (DE) | 2008-07-24 | — | — | US | disclosed |
| US-20080096969-A1 | N alpha-(Menthanecarbonyl)amino acid amides and use thereof as physiological cooling active ingredients | SYMRISE GMBH & CO. KG (DE) | 2008-04-24 | — | — | US | disclosed |
| WO-2007138031-A2 | MENTHANE CARBOXYLIC ACID N-(ALKYLTHIOALKYL)AMIDES AND USE THEREOF AS PHYSIOLOGICALLY ACTIVE COOLING ACTIVE INGREDIENTS | SYMRISE GMBH & CO. KG (DE) | 2007-12-06 | — | — | WO | disclosed |
| US-20070202188-A1 | Use of alkene carboxlic acid n alkylamides as flavouring agents | SYMRISE GMBH & CO. KG (DE) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240058243-A1 | A METHOD FOR FIGHTING MICROORGANISMS USING MENTHOL DERIVATIVES | MGLL, GCDH, GK | LMNA 3420/4885KDM4E 386/4885APOBEC3A 1531/4885 |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM4, TRPM6 | LMNA 3784/4885KDM4E 4171/4885APOBEC3A 4843/4885 |
| US-20260014103-A1 | COMBINATION REMEDY | TAS2R43, TAS2R41, TAS2R60 | LMNA 2492/4885KDM4E 3646/4885APOBEC3A 4494/4885 |
| US-20090054520-A1 | OXALIC ACID DERIVATIVES AND USE THEREOF AS PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS | OTC, OAT, HOGA1 | LMNA 3908/4885KDM4E 4647/4885APOBEC3A 3883/4885 |
| US-20250387310-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | TAS2R30, TAS2R1, TAS2R20 | LMNA 757/4885KDM4E 284/4885APOBEC3A 3475/4885 |
| US-20070202188-A1 | Use of alkene carboxlic acid n alkylamides as flavouring agents | TAS2R41, TAS2R1, TAS2R14 | LMNA 1115/4885KDM4E 3249/4885APOBEC3A 2296/4885 |
| US-20080096969-A1 | N alpha-(Menthanecarbonyl)amino acid amides and use thereof as physiological cooling active ingredients | NMBR, RIMKLA, NAAA | LMNA 929/4885KDM4E 3484/4885APOBEC3A 4504/4885 |
| US-20080175800-A1 | USE OF SPECIFIC MENTHYL 3-OXOCARBOXYLIC ACID ESTERS AS PHYSIOLOGICALLY ACTIVE COOLING SUBSTANCES | ECI1, OTC, MDH2 | LMNA 1781/4885KDM4E 3503/4885APOBEC3A 1584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.