Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.51 |
| ▸ | NPC1 | O15118 | 8/20 | 0.51 |
| ▸ | RAB9A | P51151 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | CASP3 | P42574 | 2/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | FBP1 | P09467 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31208297 | 1.00 | KDM4E (0.51) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL1748081 | 0.86 | KDM4E (0.53) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL18613864 | 0.81 | FBP1 (0.44) | KDM4ENPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL31208321 | 0.81 | FBP1 (0.44) | ALDH1A1SMN1; SMN2POLBMAPTFBP1 | |
| SCHEMBL1748273 | 0.81 | FBP1 (0.44) | ALDH1A1SMN1; SMN2POLBMAPTFBP1 | |
| SCHEMBL1748135 | 0.79 | MAPT (0.51) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL1748015 | 0.79 | SMN1; SMN2 (0.37) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL305334 | 0.77 | LMNA (0.53) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL1747969 | 0.76 | GAA (0.42) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL128635 | 0.76 | FBP1 (0.61) | KDM4ENPC1RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240409533-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2024-12-12 | — | — | US | disclosed |
| US-12071433-B2 | HMOX1 inducers | Astellas Engineered Small Molecules US, Incorporated (US) | 2024-08-27 | — | — | US | disclosed |
| US-20240051952-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2024-02-15 | — | — | US | disclosed |
| US-20220177460-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2022-06-09 | — | — | US | disclosed |
| US-20220177460-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2022-06-09 | — | — | US | disclosed |
| EP-3952990-A1 | HMOX1 INDUCERS | Mitobridge, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |
| CN-113874074-A | HMOX1 inducers | 米托布里奇公司 | 2021-12-31 | — | — | CN | disclosed |
| WO-2020210339-A1 | HMOX1 INDUCERS | MITOBRIDGE, INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| WO-2020210339-A1 | HMOX1 INDUCERS | MITOBRIDGE, INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| US-10766888-B1 | HMOX1 inducers | MITOBRIDGE INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-7968576-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | SMITH ROGER A | 2011-06-28 | — | — | US | disclosed |
| US-20090270468-A1 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | SMITH ROGER | 2009-10-29 | — | — | US | disclosed |
| US-20090253762-A1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | SMITH ROGER | 2009-10-08 | — | — | US | disclosed |
| US-20090197795-A1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2009-08-06 | — | — | US | disclosed |
| US-7423156-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |
| US-20060194859-A1 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-08-31 | — | — | US | disclosed |
| US-7091228-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-08-15 | — | — | US | disclosed |
| EP-1633722-A2 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | Bayer Pharmaceuticals Corporation (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004100881-A2 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-11-25 | — | — | WO | disclosed |
| US-20040224997-A1 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224997-A1 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | FABP4, GPR119, LIPC | KDM4E 817/4885NPC1 187/4885RAB9A 2066/4885 |
| US-10766888-B1 | HMOX1 inducers | HMOX1, HMOX2, HMBS | KDM4E 2510/4885NPC1 3451/4885RAB9A 4748/4885 |
| US-20060194859-A1 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | FABP4, GPR119, LIPC | KDM4E 817/4885NPC1 187/4885RAB9A 2066/4885 |
| US-20090270468-A1 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | FABP4, GPR119, LIPC | KDM4E 817/4885NPC1 187/4885RAB9A 2066/4885 |
| US-20240409533-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, HMBS | KDM4E 2510/4885NPC1 3451/4885RAB9A 4748/4885 |
| US-12071433-B2 | HMOX1 inducers | HMOX1, HMOX2, HMBS | KDM4E 2606/4885NPC1 3292/4885RAB9A 4725/4885 |
| US-20240051952-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, QSOX1 | KDM4E 4001/4885NPC1 2622/4885RAB9A 4324/4885 |
| US-20090197795-A1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | FABP4, GPR119, LIPC | KDM4E 817/4885NPC1 187/4885RAB9A 2066/4885 |
| US-20220177460-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, HMBS | KDM4E 2606/4885NPC1 3292/4885RAB9A 4725/4885 |
| US-20090253762-A1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | FABP4, GPR119, LIPC | KDM4E 817/4885NPC1 187/4885RAB9A 2066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.