Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17559536 | 0.81 | MEN1 (0.43) | MEN1KMT2AALDH1A1GAAKDM4E | |
| SCHEMBL20960298 | 0.78 | KDM4E (0.39) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL17559537 | 0.77 | LMNA (0.53) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL20436327 | 0.73 | ALDH1A1 (0.57) | CYP1A2KMT2AALDH1A1GAAKDM4E | |
| SCHEMBL10609908 | 0.72 | KDM4E (0.54) | ALDH1A1GAAKDM4EGLAHPGD | |
| SCHEMBL20625930 | 0.70 | HDAC1 (0.45) | MEN1KMT2AALDH1A1GAAKDM4E | |
| SCHEMBL6811081 | 0.69 | CYP1A2 (0.67) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL3600530 | 0.69 | L3MBTL1 (0.59) | CYP2C19MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL2226280 | 0.68 | PDK1 (0.72) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL19451109 | 0.68 | PARP14 (0.56) | CYP1A2CYP2C9CYP2C19ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189030-B1 | 2,2' -DIAMINO BIARYLS WITH TWO SECONDARY AMINES AND PRODUCTION THEREOF BY ELECTROCHEMICAL COUPLING | EVONIK DEGUSSA GMBH (DE) | 2019-05-01 | — | — | EP | disclosed |
| US-10196747-B2 | 2,2′-diaminobiaryls having two secondary amines | EVONIK DEGUSSA GMBH (DE) | 2019-02-05 | — | — | US | disclosed |
| US-20170305846-A1 | 2,2' -DIAMINOBIARYLS HAVING A PHTHALOYL GROUP OR SUCCINOYL GROUP | EVONIK DEGUSSA GMBH (DE) | 2017-10-26 | — | — | US | disclosed |
| US-20170298013-A1 | 2,2' -DIAMINO BIARYLS WITH TWO SECONDARY AMINES AND PRODUCTION THEREOF BY ELECTROCHEMICAL COUPLING | EVONIK DEGUSSA GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| US-20170291871-A1 | 2,2' -DIAMINOBIARYLS HAVING ONE PRIMARY AND ONE SECONDARY AMINE | EVONIK DEGUSSA GMBH (DE) | 2017-10-12 | — | — | US | disclosed |
| US-20170283961-A1 | 2,2' -DIAMINOBIARYLS HAVING TWO SECONDARY AMINES | EVONIK DEGUSSA GMBH (DE) | 2017-10-05 | — | — | US | disclosed |
| WO-2016034332-A1 | 2,2'-DIAMINO BIARYLS WITH PHTHALOYL-GROUPS OR SUCCINOYL-GROUPS | EVONIK DEGUSSA GMBH (DE) | 2016-03-10 | — | — | WO | disclosed |
| WO-2016034328-A1 | 2,2' -DIAMINO BIARYLS WITH A PRIMARY AND A SECONDARY AMINE AND PRODUCTION THEREOF BY ELECTROCHEMICAL COUPLING | EVONIK DEGUSSA GMBH (DE) | 2016-03-10 | — | — | WO | disclosed |
| WO-2016034327-A1 | 2,2' -DIAMINO BIARYLS WITH TWO SECONDARY AMINES AND PRODUCTION THEREOF BY ELECTROCHEMICAL COUPLING | EVONIK DEGUSSA GMBH (DE) | 2016-03-10 | — | — | WO | disclosed |
| WO-2016034330-A1 | NOVEL 2,2' -DIAMINO BIARYLS WITH TWO SECONDARY AMINES AND PRODUCTION THEREOF BY ELECTROCHEMICAL COUPLING | EVONIK DEGUSSA GMBH (DE) | 2016-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298013-A1 | 2,2' -DIAMINO BIARYLS WITH TWO SECONDARY AMINES AND PRODUCTION THEREOF BY ELECTROCHEMICAL COUPLING | PM20D2, XDH, DAO | CYP1A2 44/4885CYP2C9 239/4885CYP2C19 395/4885 |
| US-20170291871-A1 | 2,2' -DIAMINOBIARYLS HAVING ONE PRIMARY AND ONE SECONDARY AMINE | SAT1, AOC1, DDT | CYP1A2 2083/4885CYP2C9 3680/4885CYP2C19 3254/4885 |
| US-20170283961-A1 | 2,2' -DIAMINOBIARYLS HAVING TWO SECONDARY AMINES | AOC1, DDT, DDC | CYP1A2 1324/4885CYP2C9 2919/4885CYP2C19 2705/4885 |
| US-20170305846-A1 | 2,2' -DIAMINOBIARYLS HAVING A PHTHALOYL GROUP OR SUCCINOYL GROUP | SUCLA2, SPATS2L, SUCLG2 | CYP1A2 3692/4885CYP2C9 3517/4885CYP2C19 3640/4885 |
| US-10196747-B2 | 2,2′-diaminobiaryls having two secondary amines | AOC1, DDT, DDC | CYP1A2 1412/4885CYP2C9 2984/4885CYP2C19 2737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.