SCHEMBL1809115

SCHEMBL1809115

Ic1ccccc1N1CCNCC1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 6/20 0.62
HTR7 P34969 4/20 0.56
HTR6 P50406 3/20 0.56
HTR1A P08908 3/20 0.56
HTR3E A5X5Y0 3/20 0.56
HTR3B O95264 3/20 0.56
HTR3A P46098 3/20 0.56
HTR3D Q70Z44 3/20 0.56
HTR3C Q8WXA8 3/20 0.56
SIGMAR1 Q99720 3/20 0.56
HTR2A P28223 2/20 0.56
HTR5A P47898 2/20 0.56
CYP1A2 P05177 1/20 0.56
CYP2D6 P10635 1/20 0.56
NCF1 P14598 1/20 0.56
TSHR P16473 1/20 0.56
NFKB1 P19838 1/20 0.56
HTR1D P28221 1/20 0.56
HTR1B P28222 1/20 0.56
MTOR P42345 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15834279 0.84 ADRB1 (0.75) ADRB1HTR7HTR6HTR1AHTR3E
SCHEMBL30350850 0.80 KEAP1 (0.54) TSHRHSD17B10KDM4EALDH1A1HPGD
SCHEMBL19510747 0.80 KEAP1 (0.54) TSHRHSD17B10KDM4EALDH1A1HPGD
SCHEMBL17276365 0.78 ADRB1 (0.67) ADRB1HTR7HTR6HTR1AHTR3E
SCHEMBL22652955 0.78 ADRB1 (0.67) ADRB1HTR7HTR6HTR1AHTR3E
SCHEMBL172953 0.78 KEAP1 (0.57) HTR6TSHRLMNAALDH1A1HPGD
SCHEMBL29446047 0.77 ADRB1 (1.00) ADRB1HTR7HTR6HTR1AHTR3E
SCHEMBL5785574 0.77 ADRB1 (1.00) ADRB1HTR7HTR6HTR1AHTR3E
SCHEMBL16752537 0.77 ADRB1 (0.64) ADRB1HTR7HTR6HTR1AHTR3E
SCHEMBL15834278 0.77 ADRB1 (0.64) ADRB1HTR7HTR6HTR1AHTR3E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1147216-B1 RESORUFIN DERIVATIVES AS SUBSTRATES FOR CYP3A4 SMITHKLINE BEECHAM PLC (GB) 2004-09-08 EP claimed
US-20260070907-A1 FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE UNIV TEMPLE (US) 2026-03-12 US disclosed
US-12503458-B2 5-hydroxytryptamine receptor 7 activity modulators and their method of use TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2025-12-23 US disclosed
US-20240425487-A1 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION 2024-12-26 US disclosed
US-11897870-B2 5-hydroxytryptamine receptor 7 activity modulators and their method of use Temple University-Of The Commonwealth System Higher Education (US) 2024-02-13 US disclosed
US-20220133713-A1 SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE Temple University--of the Commonwealth System of Higher Education 2022-05-05 US disclosed
US-20220133713-A1 SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE Temple University--of the Commonwealth System of Higher Education 2022-05-05 US disclosed
EP-3738955-A1 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE Temple University Of The Commonwealth System Of Higher Education (US) 2020-11-18 EP disclosed
US-20200317648-A1 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION 2020-10-08 US disclosed
US-20200317648-A1 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION 2020-10-08 US disclosed
US-20160016941-A1 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2016-01-21 US disclosed
US-20160016941-A1 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2016-01-21 US disclosed
EP-2970223-A1 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE Temple University Of The Commonwealth System Of Higher Education (US) 2016-01-20 EP disclosed
WO-2014164756-A1 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2014-10-09 WO disclosed
US-20110118464-A1 HALOGENATED XANTHINE DERIVATIVES AND PRECURSORS THEREOF FOR ANTI-CANCER AND ANTI-METASTASIS ACTIVITY AND PREPARING METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY 2011-05-19 US disclosed
US-7524874-B2 Vanilloid receptor ligands and their use in treatments AMGEN INC. (US) 2009-04-28 US disclosed
US-20050267163-A1 Vanilloid receptor ligands and their use in treatments AMGEN INC. 2005-12-01 US disclosed
US-6329389-B1 HETEROCYCLIC AMINES AND DERIVATIVES, SOMATOSTATIN AND ANTIDIABETIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-12-11 US disclosed
EP-0244176-A2 Thienopyrimidine-2,4-dione derivatives and intermediates thereof ORTHO PHARMACEUTICAL CORPORATION (US) 1987-11-04 EP disclosed
EP-0204265-A1 N-Phenyl-4-phenyl-1-piperazine carboxamidines and related compounds as antiarrhythmic agents LABORATOIRES SYNTEX S.A. (FR) 1986-12-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12503458-B2 5-hydroxytryptamine receptor 7 activity modulators and their method of use HTR7, HTR5A, HTR6 ADRB1 79/4885HTR7 1/4885HTR6 3/4885
US-20200317648-A1 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE HTR7, HTR6, HTR5A ADRB1 95/4885HTR7 1/4885HTR6 2/4885
US-20220133713-A1 SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE SIGMAR1, TMEM97, OPRL1 ADRB1 16/4885HTR7 68/4885HTR6 77/4885
US-20260070907-A1 FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE HTR7, HTR2C, HTR5A ADRB1 89/4885HTR7 1/4885HTR6 15/4885
US-20110118464-A1 HALOGENATED XANTHINE DERIVATIVES AND PRECURSORS THEREOF FOR ANTI-CANCER AND ANTI-METASTASIS ACTIVITY AND PREPARING METHOD THEREOF TK1, XDH, KYAT1 ADRB1 527/4885HTR7 2141/4885HTR6 3272/4885
US-11897870-B2 5-hydroxytryptamine receptor 7 activity modulators and their method of use HTR7, HTR5A, HTR6 ADRB1 79/4885HTR7 1/4885HTR6 3/4885
US-20240425487-A1 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE HTR7, HTR6, HTR5A ADRB1 95/4885HTR7 1/4885HTR6 2/4885
US-20050267163-A1 Vanilloid receptor ligands and their use in treatments TRPV1, TRPV2, TRPV3 ADRB1 218/4885HTR7 120/4885HTR6 133/4885
US-20160016941-A1 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE HTR7, HTR6, HTR5A ADRB1 95/4885HTR7 1/4885HTR6 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.