SCHEMBL19397176

SCHEMBL19397176

Cc1cc(F)c2ncn(C(C)C)c2c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.51
CCNT1 O60563 12/20 0.39
CDK4 P11802 12/20 0.39
CCND1 P24385 12/20 0.39
CDK9 P50750 12/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CDK2 P24941 5/20 0.38
CCNA2 P20248 4/20 0.38
DHODH Q02127 1/20 0.37
ADORA2A P29274 1/20 0.37
ADORA2B P29275 1/20 0.37
ADORA1 P30542 1/20 0.37
PI4KA P42356 1/20 0.37
PI4K2B Q8TCG2 1/20 0.37
PI4K2A Q9BTU6 1/20 0.37
PI4KB Q9UBF8 1/20 0.37
KDM4E B2RXH2 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
CDK1 P06493 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21540519 0.82 SMN1; SMN2 (0.58) SMN1; SMN2L3MBTL1CDK2ADORA2AADORA2B
SCHEMBL20600683 0.81 SMN1; SMN2 (0.46) SMN1; SMN2CCNT1CDK4CCND1CDK9
SCHEMBL26515108 0.81 SMN1; SMN2 (0.50) SMN1; SMN2CCNT1CDK4CCND1CDK9
SCHEMBL27296365 0.81 SMN1; SMN2 (0.53) SMN1; SMN2L3MBTL1CDK2ADORA2AADORA2B
SCHEMBL26515088 0.79 SMN1; SMN2 (0.44) SMN1; SMN2CCNT1CDK4CCND1CDK9
SCHEMBL10147308 0.77 LMNA (0.40) SMN1; SMN2L3MBTL1DHODHADORA2AADORA1
SCHEMBL16938822 0.76 HCAR3 (0.43) SMN1; SMN2CCNT1CDK4CCND1CDK9
SCHEMBL24922833 0.75 DHODH (0.38) DHODH
SCHEMBL22598705 0.74 SMN1; SMN2 (0.41) SMN1; SMN2L3MBTL1CDK2DHODHADORA2A
SCHEMBL23068067 0.72 CCNT1 (0.52) SMN1; SMN2CCNT1CDK4CCND1CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240240182-A1 HUMAN CHROMOSOME 9 OPEN READING FRAME 72 (C9ORF72) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF BANK OF AMERICA, N.A. 2024-07-18 US disclosed
US-20240209339-A1 REDIRECTING RISC FOR RNA EDITING ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US disclosed
US-20240209374-A1 iRNA COMPOSITIONS AND METHODS FOR SILENCING CHITINASE 3-LIKE PROTEIN 1/YKL-40 (CHI3L1/YKL-40) PROTEIN ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US disclosed
US-20240209373-A1 ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 1 (ELOVL1) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US disclosed
US-20240209373-A1 ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 1 (ELOVL1) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US disclosed
US-12018260-B2 Tunable Reversir™ compounds ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-25 US disclosed
US-20240067972-A1 DIPEPTIDYL PEPTIDASE 4 (DPP4) IRNA COMPOSITIONS AND METHODS OF USE THEREOF BANK OF AMERICA, N.A. 2024-02-29 US disclosed
US-20240067972-A1 DIPEPTIDYL PEPTIDASE 4 (DPP4) IRNA COMPOSITIONS AND METHODS OF USE THEREOF BANK OF AMERICA, N.A. 2024-02-29 US disclosed
US-20230287424-A1 RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION BANK OF AMERICA, N.A. 2023-09-14 US disclosed
US-20230272382-A1 COMPLEMENT COMPONENT C3 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING COMPLEMENT COMPONENT C3-ASSOCIATED DISEASES BANK OF AMERICA, N.A. 2023-08-31 US disclosed
US-20220127615-A1 CORONAVIRUS IRNA COMPOSITIONS AND METHODS OF USE THEREOF BANK OF AMERICA, N.A. 2022-04-28 US disclosed
US-20220127604-A1 REVERSIR TM COMPOUNDS ALNYLAM PHARMACEUTICALS, INC. (US) 2022-04-28 US disclosed
US-20220002724-A1 AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2022-01-06 US disclosed
US-10995336-B2 Serpina1 iRNA compositions and methods of use thereof ALNYLAM PHARMACEUTICALS, INC. (US) 2021-05-04 US disclosed
US-20190316127-A1 SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF BANK OF AMERICA, N.A. 2019-10-17 US disclosed
US-10233448-B2 Modified double-stranded RNA agents ALNYLAM PHARMACEUTICALS, INC. (US) 2019-03-19 US disclosed
US-20180208927-A1 MULTI-TARGETED SINGLE ENTITY CONJUGATES ALNYLAM PHARMACEUTICALS, INC. (US) 2018-07-26 US disclosed
US-20170369872-A1 REVERSIR TM COMPOUNDS ALNYLAM PHARMACEUTICALS, INC. (US) 2017-12-28 US disclosed
US-20170275626-A1 MODIFIED DOUBLE-STRANDED RNA AGENTS BANK OF AMERICA, N.A. 2017-09-28 US disclosed
US-20170275626-A1 MODIFIED DOUBLE-STRANDED RNA AGENTS BANK OF AMERICA, N.A. 2017-09-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230287424-A1 RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION MTREX, RNASEH1, RNASE1 SMN1; SMN2 877/4885CCNT1 4743/4885CDK4 4877/4885
US-20240067972-A1 DIPEPTIDYL PEPTIDASE 4 (DPP4) IRNA COMPOSITIONS AND METHODS OF USE THEREOF DPP4, DPP3, DPP7 SMN1; SMN2 2997/4885CCNT1 4850/4885CDK4 3112/4885
US-12018260-B2 Tunable Reversir™ compounds SNRPE, PLK1, LDLR SMN1; SMN2 1252/4885CCNT1 2211/4885CDK4 1576/4885
US-20240209339-A1 REDIRECTING RISC FOR RNA EDITING ADAR, AGO2, METTL16 SMN1; SMN2 1463/4885CCNT1 4024/4885CDK4 4405/4885
US-20240209374-A1 iRNA COMPOSITIONS AND METHODS FOR SILENCING CHITINASE 3-LIKE PROTEIN 1/YKL-40 (CHI3L1/YKL-40) PROTEIN CHI3L1, CHIA, CHI3L2 SMN1; SMN2 3073/4885CCNT1 4835/4885CDK4 4843/4885
US-20220002724-A1 AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF APP, APBA1, PSEN1 SMN1; SMN2 613/4885CCNT1 4427/4885CDK4 4619/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.