SCHEMBL194099

SCHEMBL194099

CN1CCCC1CCSc1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 3/20 0.45
CHRNA3 P32297 3/20 0.45
GRIN2A Q12879 1/20 0.44
GRIN2B Q13224 1/20 0.44
CHRNB2 P17787 1/20 0.44
CHRNA4 P43681 1/20 0.44
ESRRG P62508 6/20 0.43
ESR1 P03372 4/20 0.43
ESRRB O95718 2/20 0.43
KCNH2 Q12809 1/20 0.43
CHRM3 P20309 1/20 0.41
ADRA1A P35348 1/20 0.40
HRH1 P35367 1/20 0.40
ADRA1B P35368 1/20 0.40
HRH3 Q9Y5N1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12314795 1.00 CHRNB4 (0.45) CHRNB4CHRNA3GRIN2AGRIN2BCHRNB2
Hydrochloric Acid SCHEMBL6333252 0.99 ESRRG (0.44) CHRNB4CHRNA3GRIN2AGRIN2BCHRNB2
SCHEMBL7061296 0.85 HTR6 (0.49) CHRNB4CHRNA3GRIN2BCHRNB2CHRNA4
SCHEMBL7161658 0.82 CHRNB2 (0.45) CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7062275 0.79 SIGMAR1 (0.44) KCNH2CHRM3ADRA1AHRH1HRH3
SCHEMBL7061308 0.79 CHRNB4 (0.44) CHRNB4CHRNA3CHRNB2CHRNA4KCNH2
SCHEMBL11447569 0.78 ESRRG (0.64) CHRNB4CHRNA3CHRNB2CHRNA4ESRRG
SCHEMBL7061352 0.77 CHRM3 (0.48) CHRM3
SCHEMBL11458949 0.75 ESRRG (0.61) CHRNB4CHRNA3CHRNB2CHRNA4ESRRG
SCHEMBL7061173 0.75 CHRNB4 (0.46) CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220117989-A1 COMPOSITIONS AND METHODS FOR INDUCING OR SUPPLEMENTING SOCS3 TO ABROGATE TUMOR GROWTH AND PROLIFERATIVE RETINOPATHY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-04-21 US claimed
US-20180147163-A1 COMBINATION COMPOSITIONS AND THEIR USE IN METHODS FOR TREATING OBESITY AND OBESITY-RELATED DISORDERS HELMHOLTZ ZENTRUM MUNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH) (DE) 2018-05-31 US claimed
EP-1126846-B1 Use of a nicotine receptor agonist for the manufacture of a medicament for the treatment of obsessive compulsive disorder CARLSSON A RESEARCH AB (SE) 2003-08-06 EP claimed
US-20260146254-A1 Enhancing Oligonucleotide Immunomodulatory Activity through Dianophore Long-Lasting Modification: Methods and Applications SEGENA CORPORATION S.A. (UY) 2026-05-28 US disclosed
EP-4622674-A1 ENHANCING OLIGONUCLEOTIDE IMMUNOMODULATORY ACTIVITY THROUGH DIANOPHORE LONG-LASTING MODIFICATION: METHODS AND APPLICATIONS SEGENA CORPORATION S.A. (UY) 2025-10-01 EP disclosed
US-20220244263-A1 METHODS FOR TREATING SMALL CELL NEUROENDOCRINE AND RELATED CANCERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-08-04 US disclosed
US-20220117989-A1 COMPOSITIONS AND METHODS FOR INDUCING OR SUPPLEMENTING SOCS3 TO ABROGATE TUMOR GROWTH AND PROLIFERATIVE RETINOPATHY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-04-21 US disclosed
US-10568852-B2 Combination compositions and their use in methods for treating obesity and obesity-related disorders HELMHOLTZ ZENTRUM MUNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH) (DE) 2020-02-25 US disclosed
US-20180147163-A1 COMBINATION COMPOSITIONS AND THEIR USE IN METHODS FOR TREATING OBESITY AND OBESITY-RELATED DISORDERS HELMHOLTZ ZENTRUM MUNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH) (DE) 2018-05-31 US disclosed
US-20180110768-A1 METHODS AND COMPOSITIONS FOR REDUCTION OF SIDE EFFECTS OF THERAPEUTIC TREATMENTS PARKINSON'S INSTITUTE 2018-04-26 US disclosed
US-20160235732-A1 METHODS AND COMPOSITIONS FOR REDUCTION OF SIDE EFFECTS OF THERAPEUTIC TREATMENTS PARKINSON'S INSTITUTE 2016-08-18 US disclosed
CN-1635877-A Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance NEUROSEARCH AS (DK) 2005-07-06 CN disclosed
US-20040092508-A1 Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance ANIONA APS (DK) 2004-05-13 US disclosed
EP-1358177-A2 TREATMENT OF AFFECTIVE DISORDERS BY THE COMBINED ACTION OF A NICOTINIC RECEPTOR AGONIST AND A MONOAMINERGIC SUBSTANCE NeuroSearch A/S (DK) 2003-11-05 EP disclosed
EP-1126846-B1 Use of a nicotine receptor agonist for the manufacture of a medicament for the treatment of obsessive compulsive disorder CARLSSON A RESEARCH AB (SE) 2003-08-06 EP disclosed
EP-0874818-B1 NOVEL SUBSTITUTED ARYL COMPOUNDS USEFUL AS MODULATORS OF ACETYLCHOLINE RECEPTORS MERCK & CO INC (US) 2003-05-21 EP disclosed
WO-2002030405-A2 TREATMENT OF AFFECTIVE DISORDERS BY THE COMBINED ACTION OF A NICOTINIC RECEPTOR AGONIST AND A MONOAMINERGIC SUBSTANCE NEUROSEARCH A/S (DK) 2002-04-18 WO disclosed
US-6316490-B1 FOR THERAPY OF PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, DEMENTIA, CONTROLLING PAIN MERCK & CO., INC. 2001-11-13 US disclosed
EP-1126846-A1 USE OF A NICOTINE RECEPTOR AGONIST IN THE TREATMENT OF OBSESSIVE COMPULSIVE DISORDER A Carlsson Research AB (SE) 2001-08-29 EP disclosed
WO-2000025783-A1 USE OF A NICOTINE RECEPTOR AGONIST IN THE TREATMENT OF OBSESSIVE COMPULSIVE DISORDER A CARLSSON RESEARCH AB (SE) 2000-05-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10568852-B2 Combination compositions and their use in methods for treating obesity and obesity-related disorders FABP4, LIPC, GPR119 CHRNB4 1944/4885CHRNA3 1071/4885GRIN2A 662/4885
US-20180147163-A1 COMBINATION COMPOSITIONS AND THEIR USE IN METHODS FOR TREATING OBESITY AND OBESITY-RELATED DISORDERS FABP4, LIPC, GPR119 CHRNB4 1944/4885CHRNA3 1071/4885GRIN2A 662/4885
US-20180110768-A1 METHODS AND COMPOSITIONS FOR REDUCTION OF SIDE EFFECTS OF THERAPEUTIC TREATMENTS CHRNA5, CHRM3, CHRM5 CHRNB4 16/4885CHRNA3 8/4885GRIN2A 71/4885
US-20160235732-A1 METHODS AND COMPOSITIONS FOR REDUCTION OF SIDE EFFECTS OF THERAPEUTIC TREATMENTS CHRNA5, CHRM3, CHRM5 CHRNB4 16/4885CHRNA3 8/4885GRIN2A 71/4885
US-20040092508-A1 Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance TAAR5, CHRNA5, CHRNA4 CHRNB4 18/4885CHRNA3 5/4885GRIN2A 54/4885
US-20220117989-A1 COMPOSITIONS AND METHODS FOR INDUCING OR SUPPLEMENTING SOCS3 TO ABROGATE TUMOR GROWTH AND PROLIFERATIVE RETINOPATHY EYA3, RB1, ALDH1A2 CHRNB4 157/4885CHRNA3 161/4885GRIN2A 1960/4885
US-20260146254-A1 Enhancing Oligonucleotide Immunomodulatory Activity through Dianophore Long-Lasting Modification: Methods and Applications CD44, ADAR, TLR9 CHRNB4 696/4885CHRNA3 718/4885GRIN2A 1553/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.