Pyruvate

Pyruvate

SCHEMBL1953085

CC(=O)C(=O)[O-].CC(=O)C(=O)[O-].O.[Ca+2]

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Pyruvate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.35
THRB known ✓ P10828 1/20 0.32
CA4 P22748 3/20 0.83
CA1 P00915 2/20 0.54
TSHR P16473 1/20 0.46
THPO P40225 1/20 0.46
FAHD1 Q6P587 1/20 0.43
LMNA P02545 2/20 0.39
CES1 P23141 1/20 0.38
FFAR3 O14843 1/20 0.36
LCK P06239 1/20 0.36
FYN P06241 1/20 0.36
BLM P54132 3/20 0.35
LDHA P00338 1/20 0.35
KMT2A Q03164 1/20 0.35
PMP22 Q01453 2/20 0.33
ALOX15 P16050 1/20 0.33
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyruvate SCHEMBL7031058 1.00 CA4 (0.83) CA4CA1TSHRTHPOFAHD1
Pyruvate SCHEMBL240885 0.96 CA4 (0.91) CA4CA1TSHRTHPOFAHD1
Pyruvate SCHEMBL3367247 0.92
Pyruvate SCHEMBL7941746 0.92 CA4 (0.83) CA4CA1TSHRTHPOFAHD1
Pyruvate SCHEMBL20481652 0.92 CA4 (0.92) CA4CA1TSHRTHPOFAHD1
Pyruvate SCHEMBL27565126 0.92
Pyruvate SCHEMBL7935573 0.92 CA4 (0.83) CA4CA1TSHRTHPOFAHD1
Pyruvate SCHEMBL148220 0.91
Pyruvate SCHEMBL18226 0.87
Pyruvate SCHEMBL7936306 0.87 CA4 (0.91) CA4CA1TSHRTHPOFAHD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170087106-A1 Method for supporting gut health PISCHEL IVO (DE) 2017-03-30 US claimed
US-20220040215-A1 MUSCLE TREATMENT COMPOSITION AND METHOD OF MAKING SAME Organic Medical Ventures, L.L.C. 2022-02-10 US disclosed
EP-3689343-A1 NEURODEGENERATIVE DISORDERS AND METHODS OF TREATMENT AND DIAGNOSIS THEREOF USING ANAPLEROTIC AGENTS The University of Queensland (AU) 2020-08-05 EP disclosed
US-20190255008-A1 NEURODEGENERATIVE DISORDERS AND METHODS OF TREATMENT AND DIAGNOSIS THEREOF THE UNIVERSITY OF QUEENSLAND (AU) 2019-08-22 US disclosed
US-20180207121-A1 NEURODEGENERATIVE DISORDERS AND METHODS OF TREATMENT AND DIAGNOSIS THEREOF THE UNIVERSITY OF QUEENSLAND (AU) 2018-07-26 US disclosed
US-9937215-B2 Preparations with rosehip extracts, and method of producing rosehip extracts FINZELBERG GMBH & CO., KG (DE) 2018-04-10 US disclosed
US-9833430-B2 Neurodegenerative disorders and methods of treatment and diagnosis thereof THE UNIVERSITY OF QUEENSLAND (AU) 2017-12-05 US disclosed
US-20170087106-A1 Method for supporting gut health PISCHEL IVO (DE) 2017-03-30 US disclosed
EP-3068492-A1 NEURODEGENERATIVE DISORDERS AND METHODS OF TREATMENT AND DIAGNOSIS THEREOF The University of Queensland (AU) 2016-09-21 EP disclosed
US-20160263071-A1 NEURODEGENERATIVE DISORDERS AND METHODS OF TREATMENT AND DIAGNOSIS THEREOF THE UNIVERSITY OF QUEENSLAND (AU) 2016-09-15 US disclosed
US-20040006139-A1 Choline pyruvate, method for the production thereof, formulations containing choline pyruvate and the use thereof DEGUSSA AG (DE) 2004-01-08 US disclosed
WO-2003084351-A1 USE OF CREATINE PYRUVATE FOR INCREASING STAMINA DURING HIGHLY INTENSIVE INTERMITTENT PHYSICAL EXERTION BIOGHURT BIOGARDE GMBH & CO. KG (DE) 2003-10-16 WO disclosed
EP-1343490-A1 CHOLINE PYRUVATE, METHOD FOR THE PRODUCTION THEREOF, FORMULATIONS CONTAINING CHOLINE PYRUVATE AND THE USE THEREOF Degussa AG (DE) 2003-09-17 EP disclosed
EP-0993433-B1 METHOD FOR PRODUCING CALCIUM PYRUVATES DEGUSSA (DE) 2003-02-05 EP disclosed
WO-2002051398-A1 CHOLINE PYRUVATE, METHOD FOR THE PRODUCTION THEREOF, FORMULATIONS CONTAINING CHOLINE PYRUVATE AND THE USE THEREOF DEGUSSA AG (DE) 2002-07-04 WO disclosed
US-6342631-B1 METHOD OF PRODUCING CALCIUM PYRUVATES IS DESCRIBED, IN WHICH CALCIUM SALTS OF ORGANIC ACIDS OR ACIDIC ORGANIC KETO OR HYDROXY COMPOUNDS ARE REACTED WITH PYRUVIC ACID TO FORM COMPOUND WITH LONG SHELF LIFE SKW TROSTBERG AKTIENGESELLSCHAFT (DE) 2002-01-29 US disclosed
EP-0993433-A1 METHOD FOR PRODUCING CALCIUM PYRUVATES SKW Trostberg Aktiengesellschaft (DE) 2000-04-19 EP disclosed
US-5962734-A Method of producing calcium pyruvates SKW TROSTBERG AKTIENGESELLSCHAFT (DE) 1999-10-05 US disclosed
WO-1999002479-A1 METHOD FOR PRODUCING CALCIUM PYRUVATES SKW TROSTBERG AKTIENGESELLSCHAFT (DE) 1999-01-21 WO disclosed
US-5723661-A SALT FORMATION USING CALCIUM COMPOUND WITH PYRUVIC ACID DSM CHEMIE LINZ GMBH (AT) 1998-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190255008-A1 NEURODEGENERATIVE DISORDERS AND METHODS OF TREATMENT AND DIAGNOSIS THEREOF NLN, SLC25A20, SMN1; SMN2 MEN1 2562/4885THRB 3902/4885CA4 2015/4885
US-20180207121-A1 NEURODEGENERATIVE DISORDERS AND METHODS OF TREATMENT AND DIAGNOSIS THEREOF NLN, SLC25A20, SMN1; SMN2 MEN1 2562/4885THRB 3902/4885CA4 2015/4885
US-20160263071-A1 NEURODEGENERATIVE DISORDERS AND METHODS OF TREATMENT AND DIAGNOSIS THEREOF NLN, SLC25A20, SMN1; SMN2 MEN1 2562/4885THRB 3902/4885CA4 2015/4885
US-20040006139-A1 Choline pyruvate, method for the production thereof, formulations containing choline pyruvate and the use thereof PDK1, PC, PDK4 MEN1 1006/4885THRB 1081/4885CA4 1093/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.