Methacrylic Acid

Methacrylic Acid

SCHEMBL19732811

C=C(C)C(=O)O.C=Cc1ccc(S(=O)(=O)[O-])cc1.[Na+]

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PTGS2 known ✓ P35354 6/20 0.36
TDP1 Q9NUW8 2/20 0.50
AKR1C3 P42330 6/20 0.37
ALDH1A1 P00352 2/20 0.37
AKR1C2 P52895 4/20 0.36
AKR1C1 Q04828 4/20 0.36
HCRTR1 O43613 1/20 0.35
HCRTR2 O43614 1/20 0.35
MCL1 Q07820 1/20 0.35
LMNA P02545 1/20 0.34
TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methacrylic Acid SCHEMBL2116687 0.90 TDP1 (0.50) TDP1AKR1C3ALDH1A1PTGS2HCRTR1
SCHEMBL94887 0.84 TDP1 (0.61) TDP1ALDH1A1PTGS2HCRTR1HCRTR2
SCHEMBL19915134 0.84 TDP1 (0.61) TDP1ALDH1A1PTGS2HCRTR1HCRTR2
Methacrylic Acid SCHEMBL1900788 0.84 ALDH1A1 (0.52) TDP1AKR1C3ALDH1A1PTGS2TSHR
Methacrylic Acid SCHEMBL29245724 0.82 BCAT1 (0.42) TDP1ALDH1A1LMNATSHR
Water SCHEMBL17044655 0.82 TDP1 (0.59) TDP1ALDH1A1PTGS2HCRTR1HCRTR2
SCHEMBL6035161 0.82 TDP1 (0.59) TDP1ALDH1A1PTGS2HCRTR1HCRTR2
Water SCHEMBL2898586 0.82 TDP1 (0.59) TDP1ALDH1A1PTGS2HCRTR1HCRTR2
Methacrylic Acid SCHEMBL27602455 0.82 ALDH1A1 (0.50) TDP1AKR1C3ALDH1A1PTGS2TSHR
SCHEMBL29120853 0.81 TDP1 (0.41) TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3261155-B1 CONDUCTIVE PASTE AND MIXTURE PASTE FOR LITHIUM ION BATTERY POSITIVE ELECTRODE KANSAI PAINT CO LTD (JP) 2023-11-01 EP disclosed
US-10468683-B2 Conductive paste and mixture paste for lithium ion battery positive electrode KANSAI PAINT CO., LTD. (JP) 2019-11-05 US disclosed
US-20170373319-A1 CONDUCTIVE PASTE AND MIXTURE PASTE FOR LITHIUM ION BATTERY POSITIVE ELECTRODE KANSAI PAINT CO., LTD. (JP) 2017-12-28 US disclosed
EP-3261155-A1 CONDUCTIVE PASTE AND MIXTURE PASTE FOR LITHIUM ION BATTERY POSITIVE ELECTRODE Kansai Paint Co., Ltd (JP) 2017-12-27 EP disclosed