Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL19732811 | 0.90 | TDP1 (0.50) | TDP1ALDH1A1LMNAHCRTR1HCRTR2 | |
| Methacrylic Acid SCHEMBL28243618 | 0.87 | TDP1 (0.70) | TDP1ALDH1A1LMNAHCRTR1HCRTR2 | |
| Methacrylic Acid SCHEMBL460576 | 0.86 | ALDH1A1 (0.50) | TDP1ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL19915134 | 0.84 | TDP1 (0.61) | TDP1ALDH1A1LMNAHCRTR1HCRTR2 | |
| SCHEMBL94887 | 0.84 | TDP1 (0.61) | TDP1ALDH1A1LMNAHCRTR1HCRTR2 | |
| Potassium Ion SCHEMBL331671 | 0.84 | TDP1 (0.61) | TDP1ALDH1A1LMNAHCRTR1HCRTR2 | |
| Water SCHEMBL2898586 | 0.82 | TDP1 (0.59) | TDP1ALDH1A1LMNAHCRTR1HCRTR2 | |
| SCHEMBL6035161 | 0.82 | TDP1 (0.59) | TDP1ALDH1A1LMNAHCRTR1HCRTR2 | |
| Water SCHEMBL17044655 | 0.82 | TDP1 (0.59) | TDP1ALDH1A1LMNAHCRTR1HCRTR2 | |
| SCHEMBL29120853 | 0.81 | TDP1 (0.41) | TDP1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8444961-B2 | RNA virus infection inhibitor, method for inhibition of infection by RNA virus, RNA virus infection-inhibiting product, and use as RNA virus infection inhibitor | SEKISUI CHEMICAL CO., LTD. (JP) | 2013-05-21 | — | — | US | disclosed |
| EP-2444095-A1 | RNA VIRUS INFECTION INHIBITOR, METHOD FOR INHIBITION OF INFECTION BY RNA VIRUS, PRODUCTS FOR INHIBITION OF INFECTION BY RNA VIRUS, AND USE AS RNA VIRUS INFECTION INHIBITOR | Sekisui Chemical Co., Ltd. (JP) | 2012-04-25 | — | — | EP | disclosed |
| US-20120093763-A1 | RNA VIRUS INFECTION INHIBITOR, METHOD FOR INHIBITION OF INFECTION BY RNA VIRUS, RNA VIRUS INFECTION-INHIBITING PRODUCT, AND USE AS RNA VIRUS INFECTION INHIBITOR | SEKISUI CHEMICAL CO., LTD. (JP) | 2012-04-19 | — | — | US | disclosed |
| EP-2160946-A1 | Process for the preparation of an antimicrobial article | Polymers CRC Limited (AU) | 2010-03-10 | — | — | EP | disclosed |
| EP-2160945-A1 | Antimicrobial Article | Polymers CRC Limited (AU) | 2010-03-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120093763-A1 | RNA VIRUS INFECTION INHIBITOR, METHOD FOR INHIBITION OF INFECTION BY RNA VIRUS, RNA VIRUS INFECTION-INHIBITING PRODUCT, AND USE AS RNA VIRUS INFECTION INHIBITOR | NSUN3, RNASEH1, RNASEL | PTGS2 3322/4885TDP1 2770/4885ALDH1A1 2981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.