Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118174 | 0.84 | CRHR1 (0.40) | PDE4BCRHR1CRHR2 | |
| SCHEMBL20118213 | 0.83 | LMNA (0.42) | PDE4BCRHR1CRHR2HTR1A | |
| SCHEMBL20118187 | 0.81 | PDE4B (0.41) | PDE4BCRHR1CRHR2 | |
| SCHEMBL20118184 | 0.81 | CRHR1 (0.39) | PDE4BCRHR1CRHR2 | |
| SCHEMBL20118188 | 0.79 | KDM4E (0.47) | — | |
| SCHEMBL20118220 | 0.78 | ALDH1A1 (0.50) | PDE4BCRHR1CRHR2 | |
| SCHEMBL20118169 | 0.77 | P2RX7 (0.35) | CRHR1CRHR2 | |
| SCHEMBL20118172 | 0.77 | P2RX7 (0.35) | CRHR1CRHR2 | |
| SCHEMBL20118191 | 0.76 | CRHR1 (0.43) | PDE4BCRHR1CRHR2 | |
| SCHEMBL20118231 | 0.74 | CRHR1 (0.37) | CRHR1CRHR2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078009-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |