Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118174 | 0.84 | CRHR1 (0.40) | CRHR1CRHR2HPGDPDE4BMEN1 | |
| SCHEMBL20118187 | 0.82 | PDE4B (0.41) | CRHR1CRHR2HPGDPDE4B | |
| SCHEMBL20118213 | 0.82 | LMNA (0.42) | CRHR1CRHR2HPGDPDE4B | |
| SCHEMBL20118172 | 0.81 | P2RX7 (0.35) | CRHR1CRHR2P2RX7CYP2D6CYP2C19 | |
| SCHEMBL20118169 | 0.81 | P2RX7 (0.35) | CRHR1CRHR2P2RX7CYP2D6CYP2C19 | |
| SCHEMBL20118407 | 0.81 | PDE4B (0.40) | CRHR1CRHR2PDE4B | |
| SCHEMBL20118188 | 0.80 | KDM4E (0.47) | — | |
| SCHEMBL20118220 | 0.77 | ALDH1A1 (0.50) | CRHR1CRHR2HPGDPDE4B | |
| SCHEMBL20118231 | 0.76 | CRHR1 (0.37) | CRHR1CRHR2HPGDKCNH2 | |
| SCHEMBL20118401 | 0.76 | PSEN1 (0.37) | CRHR1CRHR2P2RX7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078009-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |