Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.41 |
| ▸ | TNKS | O95271 | 3/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118213 | 0.91 | LMNA (0.42) | PDE4BTNKSTNKS2CRHR1CRHR2 | |
| SCHEMBL20118188 | 0.83 | KDM4E (0.47) | TNKS | |
| SCHEMBL20118174 | 0.82 | CRHR1 (0.40) | PDE4BCRHR1CRHR2HPGD | |
| SCHEMBL20118184 | 0.82 | CRHR1 (0.39) | PDE4BCRHR1CRHR2HPGD | |
| SCHEMBL20118407 | 0.81 | PDE4B (0.40) | PDE4BCRHR1CRHR2 | |
| SCHEMBL20118132 | 0.81 | LMNA (0.46) | PDE4BTNKSTNKS2CRHR1CRHR2 | |
| SCHEMBL20118220 | 0.79 | ALDH1A1 (0.50) | PDE4BCRHR1CRHR2HPGDHSD11B1 | |
| SCHEMBL20118070 | 0.78 | CRHR1 (0.42) | PDE4BCNR1CNR2CRHR1CRHR2 | |
| SCHEMBL20118231 | 0.77 | CRHR1 (0.37) | CNR1CNR2CRHR1CRHR2HPGD | |
| SCHEMBL20118172 | 0.77 | P2RX7 (0.35) | CRHR1CRHR2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078009-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |