Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 1.00 |
| ▸ | MMP9 | P14780 | 5/20 | 1.00 |
| ▸ | MMP13 | P45452 | 3/20 | 1.00 |
| ▸ | MMP8 | P22894 | 1/20 | 0.65 |
| ▸ | CA12 | O43570 | 4/20 | 0.62 |
| ▸ | CA1 | P00915 | 4/20 | 0.62 |
| ▸ | CA2 | P00918 | 4/20 | 0.62 |
| ▸ | CA7 | P43166 | 4/20 | 0.62 |
| ▸ | CA9 | Q16790 | 4/20 | 0.62 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.62 |
| ▸ | TYR | P14679 | 3/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.53 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.53 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.53 |
| ▸ | F3 | P13726 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19958251 | 0.94 | MMP2 (0.88) | MMP2MMP9MMP13MMP8CA12 | |
| SCHEMBL18427608 | 0.85 | MMP2 (0.74) | MMP2MMP9MMP13MMP8CA12 | |
| SCHEMBL10084348 | 0.85 | MMP2 (0.73) | MMP2MMP9MMP13MMP8MAOB | |
| SCHEMBL2123091 | 0.83 | MMP2 (0.70) | MMP2MMP9MMP13MMP8MAOB | |
| SCHEMBL2124212 | 0.83 | MMP13 (0.70) | MMP2MMP9MMP13MMP8MAOB | |
| SCHEMBL30540958 | 0.79 | MMP2 (1.00) | MMP2MMP9MMP13MMP8CA12 | |
| SCHEMBL2122001 | 0.79 | MMP2 (1.00) | MMP2MMP9MMP13MMP8CA12 | |
| SCHEMBL10077695 | 0.77 | MMP2 (0.62) | MMP2MMP9MMP13MMP8MAOB | |
| SCHEMBL13191552 | 0.77 | MMP2 (0.62) | MMP2MMP9MMP13CA12CA1 | |
| Methyl P-Hydroxycinnamate SCHEMBL547438 | 0.77 | CA12 (1.00) | MMP2MMP9MMP13CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240360068-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2024-10-31 | — | — | US | disclosed |
| US-20230265041-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2023-08-24 | — | — | US | disclosed |
| US-11608309-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2023-03-21 | — | — | US | disclosed |
| US-20210322346-A1 | CHEMICALLY MODIFIED CURCUMINS FOR USE IN THE PRODUCTION OF LIPOXINS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2021-10-21 | — | — | US | disclosed |
| US-20210053905-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2021-02-25 | — | — | US | disclosed |
| US-20210053905-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2021-02-25 | — | — | US | disclosed |
| US-10669227-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2020-06-02 | — | — | US | disclosed |
| US-10669227-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190254945-A1 | INHIBITION OF MELANOGENESIS BY CHEMICALLY MODIFIED CURCUMINS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-08-22 | — | — | US | disclosed |
| EP-3206488-B1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | UNIV NEW YORK STATE RES FOUND (US) | 2019-08-21 | — | — | EP | disclosed |
| US-9220695-B2 | Polyenolic zinc-binding agents (pezbins) actively promote inactivation of cancer stem cells and potentiate cytotoxic anti-tumor drug substances | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2015-12-29 | — | — | US | disclosed |
| US-9187406-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2015-11-17 | — | — | US | disclosed |
| US-9187406-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150150834-A1 | POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES | CHEM-MASTER INTERNATIONAL, INC. (US) | 2015-06-04 | — | — | US | disclosed |
| US-20150073021-A1 | CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2015-03-12 | — | — | US | disclosed |
| US-20140275271-A1 | NOVEL MODIFIED CURCUMINS AND THEIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2014-09-18 | — | — | US | disclosed |
| US-20120095051-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | CHEM-MASTER INTERNATIONAL, INC. | 2012-04-19 | — | — | US | disclosed |
| US-20120095051-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | CHEM-MASTER INTERNATIONAL, INC. | 2012-04-19 | — | — | US | disclosed |
| WO-2010132815-A9 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2011-01-13 | — | — | WO | disclosed |
| WO-2010132815-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2010-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150073021-A1 | CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR | ANTXR2, APAF1, LITAF | MMP2 224/4885MMP9 1104/4885MMP13 928/4885 |
| US-20230265041-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES | NFRKB, NFKBIA, NFKB1 | MMP2 32/4885MMP9 17/4885MMP13 12/4885 |
| US-20120095051-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | MMP2 19/4885MMP9 12/4885MMP13 11/4885 |
| US-10669227-B2 | Curcumin analogues as zinc chelators and their uses | NFKBIA, NFKB1, NFKB2 | MMP2 19/4885MMP9 12/4885MMP13 11/4885 |
| US-20140275271-A1 | NOVEL MODIFIED CURCUMINS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | MMP2 6/4885MMP9 8/4885MMP13 9/4885 |
| US-20150150834-A1 | POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES | BAZ2B, CEBPZ, BAZ2A | MMP2 2518/4885MMP9 1634/4885MMP13 886/4885 |
| US-11608309-B2 | Curcumin analogues as zinc chelators and their uses | NFKBIA, NFKB1, NFKB2 | MMP2 19/4885MMP9 12/4885MMP13 11/4885 |
| US-20210053905-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | MMP2 19/4885MMP9 12/4885MMP13 11/4885 |
| US-20190254945-A1 | INHIBITION OF MELANOGENESIS BY CHEMICALLY MODIFIED CURCUMINS | TYR, MC1R, MITF | MMP2 1633/4885MMP9 1649/4885MMP13 628/4885 |
| US-20240360068-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | MMP2 19/4885MMP9 12/4885MMP13 11/4885 |
| US-20210322346-A1 | CHEMICALLY MODIFIED CURCUMINS FOR USE IN THE PRODUCTION OF LIPOXINS | ALOX15B, ALOX15, ALOX12 | MMP2 691/4885MMP9 1330/4885MMP13 483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.