Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fosamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 3/20 | 0.41 |
| ▸ | CA4 known ✓ | P22748 | 2/20 | 0.41 |
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.35 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 2/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11135410 | 0.79 | MMP1 (0.43) | MMP1MMP2CA1TSHRTP53 | |
| SCHEMBL11601327 | 0.79 | MMP1 (0.43) | MMP1MMP2CA1TSHRTP53 | |
| Disodium Ethoxy(Oxido)Phosphinecarboxylate Oxide SCHEMBL11601322 | 0.79 | LMNA (0.43) | MMP1MMP2TSHRTP53TDP1 | |
| Sodium Ethyl Ethoxycarbonylphosphonate SCHEMBL10890101 | 0.76 | MMP1 (0.41) | MMP1MMP2CA1TSHRALOX15 | |
| SCHEMBL11597408 | 0.76 | MMP1 (0.45) | MMP1MMP2CA1TSHRTP53 | |
| SCHEMBL10508956 | 0.73 | CA12 (0.48) | CA1TSHRALOX15TP53TDP1 | |
| SCHEMBL10889977 | 0.72 | MMP1 (0.39) | MMP1MMP2CA1CA4CA5A | |
| SCHEMBL5349960 | 0.72 | — | — | |
| Fosamine SCHEMBL8535758 | 0.71 | TSHR (0.43) | CA1CA4TSHRALOX15TP53 | |
| SCHEMBL27279216 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160212993-A1 | ADJUVANT COMPOSITIONS | SYNGENTA LIMITED (GB) | 2016-07-28 | — | — | US | disclosed |
| US-20150313215-A1 | PESTICIDAL MIXTURES | SYNGENTA CROP PROTECTION LLC (US) | 2015-11-05 | — | — | US | disclosed |
| US-20150011573-A1 | ADJUVANT COMPOSITIONS | SYNGENTA PARTICIPATIONS AG (CH) | 2015-01-08 | — | — | US | disclosed |
| EP-2811828-A1 | ADJUVANT COMPOSITIONS | Syngenta Participations AG (CH) | 2014-12-17 | — | — | EP | disclosed |
| US-8852618-B2 | Insecticidal mixture containing gamma-cyhalothrin | SYNGENTA LIMITED (GB) | 2014-10-07 | — | — | US | disclosed |
| US-20130203590-A1 | PESTICIDAL MIXTURES | SYNGENTA CROP PROTECTION LLC (US) | 2013-08-08 | — | — | US | disclosed |
| WO-2013110553-A1 | ADJUVANT COMPOSITIONS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-08-01 | — | — | WO | disclosed |
| EP-2549878-A2 | PESTICIDAL MIXTURES | Syngenta Participations AG (CH) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011117272-A2 | PESTICIDAL MIXTURES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-09-29 | — | — | WO | disclosed |
| US-7906127-B2 | Insecticidal mixture containing gamma-cyhalothrin | SYNGENTA LIMITED (GB) | 2011-03-15 | — | — | US | disclosed |
| EP-2260708-A2 | Insecticidal mixture containing gamma-cyhalothrin | Syngenta Limited (GB) | 2010-12-15 | — | — | EP | disclosed |
| US-20100081714-A1 | INSECTICIDAL MIXTURE CONTAINING GAMMA-CYHALOTHRIN | CLOUGH MARTIN STEPHEN | 2010-04-01 | — | — | US | disclosed |
| EP-2087791-A2 | Insecticidal mixture containing gamma-cyhalothrin | Syngenta Limited (GB) | 2009-08-12 | — | — | EP | disclosed |
| US-20050233986-A1 | Insecticidal mixture containing gamma-cyhalothrin | SYNGENTA LIMITED (GB) | 2005-10-20 | — | — | US | disclosed |
| EP-1414304-A1 | INSECTICIDAL MIXTURE CONTAINING GAMMA-CYHALOTHRIN | Syngenta Limited (GB) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003011031-A1 | INSECTICIDAL MIXTURE CONTAINING GAMMA-CYHALOTHRIN | SYNGENTA LIMITED (GB) | 2003-02-13 | — | — | WO | disclosed |
| EP-1119547-A1 | SUBSTITUTED PYRROLIDINONE, THIAZOLIDINONE OR OXAZOLIDINONE AS HERBICIDES | Syngenta Limited (GB) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000071785-A2 | 2-CYLCOALKYLCARBONYLCYCLOHEXANE-1,3-DIONE DERIVATIVES AS HERBICIDES | ZENECA LIMITED (GB) | 2000-11-30 | — | — | WO | disclosed |
| WO-2000021928-A1 | SUBSTITUTED PYRROLIDINONE, THIAZOLIDINONE OR OXAZOLIDINONE AS HERBICIDES | SYNGENTA LIMITED (GB) | 2000-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160212993-A1 | ADJUVANT COMPOSITIONS | TLR3, MYD88, ALOX5 | CA1 927/4885CA4 2473/4885CA12 857/4885 |
| US-20150011573-A1 | ADJUVANT COMPOSITIONS | TLR3, MYD88, ALOX5 | CA1 927/4885CA4 2473/4885CA12 857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.