Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR known ✓ | P00374 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21810713 | 1.00 | DNM1 (0.39) | DNM1DHFRMEN1KMT2ATP53 | |
| SCHEMBL21810704 | 1.00 | DNM1 (0.39) | DNM1DHFRMEN1KMT2ATP53 | |
| SCHEMBL810136 | 0.98 | DNM1 (0.40) | DNM1MEN1KMT2ATP53MAPK1 | |
| SCHEMBL308300 | 0.98 | DNM1 (0.40) | DNM1MEN1KMT2ATP53MAPK1 | |
| SCHEMBL3863463 | 0.98 | DNM1 (0.40) | DNM1MEN1KMT2ATP53MAPK1 | |
| SCHEMBL308412 | 0.98 | DNM1 (0.40) | DNM1MEN1KMT2ATP53MAPK1 | |
| SCHEMBL4532567 | 0.96 | LTA4H (0.38) | DNM1MEN1KMT2ATP53MAPK1 | |
| Tetramethylammonium Ion SCHEMBL8574603 | 0.92 | DNM1 (0.44) | DNM1MEN1KMT2ATP53MAPK1 | |
| Tetramethylammonium Ion SCHEMBL3615088 | 0.92 | DNM1 (0.44) | DNM1MEN1KMT2ATP53MAPK1 | |
| SCHEMBL8568117 | 0.92 | DNM1 (0.37) | DNM1MEN1KMT2ATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12421264-B2 | Compounds and methods for the treatment of pathogenic Neisseria | INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CA) | 2025-09-23 | — | — | US | disclosed |
| US-20220089626-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF PATHOGENIC NEISSERIA | INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CA) | 2022-03-24 | — | — | US | disclosed |
| WO-2020051701-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF PATHOGENIC NEISSERIA | INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CA) | 2020-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089626-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF PATHOGENIC NEISSERIA | NMBR, MLEC, BPGM | DHFR 3043/4885DNM1 2403/4885MEN1 53/4885 |
| US-12421264-B2 | Compounds and methods for the treatment of pathogenic Neisseria | NMBR, MLEC, BPGM | DHFR 3043/4885DNM1 2403/4885MEN1 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.