SCHEMBL2219638

SCHEMBL2219638

Nc1cncc(-c2cncc(N)c2N)c1N

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
AOC1 P19801 2/20 0.32
AOC3 Q16853 2/20 0.32
CDK2 P24941 1/20 0.31
PRKCZ Q05513 1/20 0.30
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
KDM6B O15054 1/20 0.30
KDM4A O75164 1/20 0.30
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30
THRB P10828 1/20 0.30
KMT2A Q03164 1/20 0.30
KDM4D Q6B0I6 1/20 0.30
KDM4C Q9H3R0 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2955988 0.83
SCHEMBL2221297 0.78 MAPT (0.43) AOC1AOC3MEN1ALDH1A1MAPT
SCHEMBL2263390 0.75 TDO2 (0.47) CDK2PRKCZKDM4EMEN1ALDH1A1
SCHEMBL2219633 0.73 CYP2A6 (0.52) KDM4EMEN1ALDH1A1MAPT
SCHEMBL15301520 0.73 CYP11B2 (0.39)
SCHEMBL17555456 0.72 ALDH1A1 (0.42) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL15301806 0.72 CYP2A6 (0.50)
SCHEMBL18476225 0.72 PPARA (0.31)
SCHEMBL15301581 0.72 TDO2 (0.50) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL15301561 0.72 CYP1A2 (0.41) CDK2PRKCZMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260116878-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF BIOSPLICE THERAPEUTICS INC (US) 2026-04-30 US disclosed
US-20240116927-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF MED-PATHWAYS II LIMITED (VG) 2024-04-11 US disclosed
US-11697649-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof BIOSPLICE THERAPEUTICS, INC. (US) 2023-07-11 US disclosed
US-20230013144-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF TENARX, INC. 2023-01-19 US disclosed
EP-3915988-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF BioSplice Therapeutics, Inc. (US) 2021-12-01 EP disclosed
US-10947228-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof SAMUMED, LLC (US) 2021-03-16 US disclosed
WO-2020150545-A1 PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY SAMUMED, LLC (US) 2020-07-23 WO disclosed
US-20200190082-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF TENARX, INC. 2020-06-18 US disclosed
US-20200155525-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF SAMUMED, LLC 2020-05-21 US disclosed
US-10407425-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof SAMUMED, LLC (US) 2019-09-10 US disclosed
WO-2013166396-A2 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF SAMUMED, LLC (US) 2013-11-07 WO disclosed
US-20130296302-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF SAMUMED, LLC (US) 2013-11-07 US disclosed
US-20130296307-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF VICKERS VENTURE FUND VI PTE. LTD. (SG) 2013-11-07 US disclosed
US-20130267495-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF SAMUMED, LLC (US) 2013-10-10 US disclosed
WO-2013151708-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF SAMUMED, LLC (US) 2013-10-10 WO disclosed
US-20130225576-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF SAMUMED, LLC (US) 2013-08-29 US disclosed
US-8450340-B2 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof SAMUMED, LLC (US) 2013-05-28 US disclosed
EP-2515655-A1 1H-PYRAZOLO[3,4-BETA]PYRIDINES AND THERAPEUTIC USES THEREOF Samumed, LLC (US) 2012-10-31 EP disclosed
US-20110190290-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-08-04 US disclosed
WO-2011084486-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-07-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10947228-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof WNT1, WNT3, WNT3A AOC1 4800/4885AOC3 3362/4885CDK2 180/4885
US-20110190290-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF BRCA1, THPO, PDXK AOC1 1372/4885AOC3 810/4885CDK2 885/4885
US-20130225576-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF BRCA1, THPO, PDXK AOC1 1372/4885AOC3 810/4885CDK2 885/4885
US-11697649-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof WNT1, WNT3, WNT3A AOC1 4800/4885AOC3 3362/4885CDK2 180/4885
US-20230013144-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A AOC1 4800/4885AOC3 3362/4885CDK2 180/4885
US-20130296302-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF COL1A1, NOX4, FGF1 AOC1 1338/4885AOC3 436/4885CDK2 372/4885
US-20240116927-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A AOC1 4800/4885AOC3 3362/4885CDK2 180/4885
US-20200190082-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A AOC1 4800/4885AOC3 3362/4885CDK2 180/4885
US-10407425-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof WNT1, WNT3, WNT3A AOC1 4800/4885AOC3 3362/4885CDK2 180/4885
US-20260116878-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A AOC1 4355/4885AOC3 2312/4885CDK2 463/4885
US-20130296307-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF BRCA1, THPO, PDXK AOC1 1372/4885AOC3 810/4885CDK2 885/4885
US-20200155525-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF COL1A1, NOX4, FGF1 AOC1 1338/4885AOC3 436/4885CDK2 372/4885
US-20130267495-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A AOC1 4800/4885AOC3 3362/4885CDK2 180/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.