SCHEMBL2237075

SCHEMBL2237075

Cc1ccc(-c2c[c]cs2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
ALDH1A1 P00352 7/20 0.33
NPC1 O15118 4/20 0.33
RAB9A P51151 4/20 0.33
GAA P10253 2/20 0.33
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33
MAPT P10636 1/20 0.33
IDO1 P14902 1/20 0.33
SMN1; SMN2 Q16637 4/20 0.33
KDM4E B2RXH2 3/20 0.33
NFKB1 P19838 2/20 0.33
NFKB2 Q00653 2/20 0.33
RELA Q04206 2/20 0.33
POLB P06746 1/20 0.31
KMT2A Q03164 1/20 0.31
NOTUM Q6P988 1/20 0.31
LMNA P02545 3/20 0.31
HSD17B1 P14061 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2753722 0.78 HSD17B1 (0.32) HSD17B1HSD17B2
SCHEMBL27702426 0.78 RAB9A (0.36) NPC1RAB9AMAPTSMN1; SMN2KDM4E
SCHEMBL2753887 0.72 MAPT (0.36) TDP1ALDH1A1NPC1RAB9AGAA
SCHEMBL2753192 0.69 HSD17B1 (0.41) ALDH1A1NPC1RAB9AKDM4ENOTUM
SCHEMBL695227 0.68 SLC6A7 (0.41) ACHETDP1ALDH1A1NPC1RAB9A
SCHEMBL2752991 0.68 NUDT1 (0.33)
SCHEMBL28274292 0.67 HPGD (0.40) ACHETDP1ALDH1A1NPC1RAB9A
Water SCHEMBL3680095 0.66 ACHE (0.67) ACHETDP1ALDH1A1IDO1LMNA
Water SCHEMBL3763584 0.66 ACHE (0.67) ACHETDP1ALDH1A1IDO1LMNA
SCHEMBL9968693 0.66 APP (0.55) ACHETDP1ESR1ESR2HSD17B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230331881-A1 PRODUCTION OF POLYPROPYLENE WITH LOW VOLATILES BOREALIS AG (AT) 2023-10-19 US disclosed
US-20230142911-A1 OLEFIN POLYMERIZATION CATALYST, OLEFIN POLYMERIZATION CATALYST PRODUCTION METHOD, AND OLEFIN POLYMER PRODUCTION METHOD USING THE OLEFIN POLYMERIZATION CATALYST JAPAN POLYPROPYLENE CORPORATION (JP) 2023-05-11 US disclosed
CN-115702174-A Production of polypropylene with low volatiles 博里利斯股份公司 2023-02-14 CN disclosed
EP-4105246-A1 CATALYST FOR OLEFIN POLYMERIZATION, PRODUCTION METHOD FOR CATALYST FOR OLEFIN POLYMERIZATION, AND PRODUCTION METHOD FOR OLEFIN POLYMER USING SAID CATALYST FOR OLEFIN POLYMERIZATION Japan Polypropylene Corporation (JP) 2022-12-21 EP disclosed
US-20220396695-A1 HETEROPHASIC PROPYLENE ETHYLENE COPOLYMER COMPOSITION WITH DESIRABLE BALANCE OF MECHANICAL PROPERTIES BOREALIS AG (AT) 2022-12-15 US disclosed
CN-115315451-A Olefin polymerization catalyst, method for producing olefin polymerization catalyst, and method for producing olefin polymer using olefin polymerization catalyst 日本聚丙烯株式会社 2022-11-08 CN disclosed
CN-114616280-A Heterophasic propylene ethylene copolymer compositions having a desirable balance of mechanical properties 北欧化工公司 2022-06-10 CN disclosed
WO-2021254938-A1 PRODUCTION OF POLYPROPYLENE WITH LOW VOLATILES BOREALIS AG (AT) 2021-12-23 WO disclosed
EP-3925986-A1 PRODUCTION OF POLYPROPYLENE WITH LOW VOLATILES Borealis AG (AT) 2021-12-22 EP disclosed
CN-110483670-B Metallocene complex and process for producing olefin polymer 日本聚丙烯株式会社 2021-11-30 CN disclosed
US-9902749-B2 Metallocene complex and olefin polymerization method JAPAN POLYPROPYLENE CORPORATION (JP) 2018-02-27 US disclosed
US-20170081431-A1 METALLOCENE COMPLEX AND METHOD FOR PRODUCING OLEFIN POLYMER JAPAN POLYPROPYLENE CORPORATION (JP) 2017-03-23 US disclosed
EP-3121187-A1 METALLOCENE COMPLEX AND METHOD FOR MANUFACTURING OLEFIN POLYMER Japan Polypropylene Corporation (JP) 2017-01-25 EP disclosed
EP-2915816-B1 METALLOCENE COMPLEX AND OLEFIN POLYMERIZATION METHOD JAPAN POLYPROPYLENE CORP (JP) 2016-05-25 EP disclosed
US-20150266914-A1 METALLOCENE COMPLEX AND OLEFIN POLYMERIZATION METHOD JAPAN POLYPROPYLENE CORPORATION (JP) 2015-09-24 US disclosed
EP-2915816-A1 METALLOCENE COMPLEX AND OLEFIN POLYMERIZATION METHOD Japan Polypropylene Corporation (JP) 2015-09-09 EP disclosed
EP-2360163-B1 METALLOCENE COMPLEX AND METHOD FOR POLYMERIZING OLEFIN JAPAN POLYPROPYLENE CORP (JP) 2014-06-25 EP disclosed
US-8461365-B2 Metallocene complex and polymerization method of olefin JAPAN POLYPROPYLENE CORPORATION (JP) 2013-06-11 US disclosed
US-20110230622-A1 METALLOCENE COMPLEX AND POLYMERIZATION METHOD OF OLEFIN JAPAN POLYPROPYLENE CORPORATION (JP) 2011-09-22 US disclosed
EP-2360163-A1 METALLOCENE COMPLEX AND METHOD FOR POLYMERIZING OLEFIN Japan Polypropylene Corporation (JP) 2011-08-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230622-A1 METALLOCENE COMPLEX AND POLYMERIZATION METHOD OF OLEFIN ALOX12, ALOX15, ALOX15B ACHE 2721/4885TDP1 3705/4885ALDH1A1 477/4885
US-20170081431-A1 METALLOCENE COMPLEX AND METHOD FOR PRODUCING OLEFIN POLYMER PPOX, ALOX12, PORCN ACHE 3668/4885TDP1 2634/4885ALDH1A1 1301/4885
US-20150266914-A1 METALLOCENE COMPLEX AND OLEFIN POLYMERIZATION METHOD POR, OPRM1, ALOX12 ACHE 3496/4885TDP1 2786/4885ALDH1A1 986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.