SCHEMBL2274245

SCHEMBL2274245

Cc1cccc(C(=O)Nc2cc(CCc3ccccc3)ccc2C(=O)O)c1C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.49
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
AKR1B10 O60218 1/20 0.49
TRPA1 O75762 1/20 0.49
ABCB11 O95342 1/20 0.49
DHFR P00374 1/20 0.49
MPO P05164 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CHRM1 P11229 1/20 0.49
CYP2C9 P11712 1/20 0.49
AKR1B1 P15121 1/20 0.49
PTGS1 P23219 1/20 0.49
PTGS2 P35354 1/20 0.49
AKR1C3 P42330 1/20 0.49
AKR1C2 P52895 1/20 0.49
AKR1C1 Q04828 1/20 0.49
HIF1A Q16665 1/20 0.49
NAPRT Q6XQN6 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276177 0.91 SLC16A3 (0.55) POLBSLC16A3PLK1PLK3KDM4E
SCHEMBL4225455 0.82 MEN1 (0.66) LMNAMEN1KMT2AAKR1B10TRPA1
SCHEMBL2270880 0.82 ALOX15 (0.60) LMNAMEN1KMT2ATDP1NPC1
SCHEMBL2276434 0.81 RAB9A (0.55) MEN1KMT2ATDP1POLBNPC1
SCHEMBL2275852 0.81 MEN1 (0.55) LMNAMEN1KMT2ACYP1A2TDP1
SCHEMBL2275722 0.81 ACLY (0.57) LMNAMEN1KMT2AAKR1B10TRPA1
SCHEMBL2270906 0.81 MEN1 (0.56) LMNAMEN1KMT2ATDP1RAB9A
SCHEMBL2273979 0.81 ALDH1A1 (0.58) LMNAMEN1KMT2ATDP1POLB
SCHEMBL2275929 0.80 KMT2A (0.62) MEN1KMT2ATDP1MAPTPLK1
SCHEMBL2274146 0.80 PLK1 (0.56) MEN1KMT2ATDP1POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 LMNA 3235/4885MEN1 3105/4885KMT2A 1669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.