Styrene

Styrene

SCHEMBL23200370

C=C(C)CS(=O)(=O)[O-].C=Cc1ccccc1.[Na+]

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 known ✓ O43570 2/20 0.37
CA2 known ✓ P00918 2/20 0.37
ALDH1A1 P00352 4/20 0.45
TSHR P16473 2/20 0.45
TDP1 Q9NUW8 2/20 0.41
CA9 Q16790 2/20 0.37
FBP1 P09467 1/20 0.34
CYP3A4 P08684 1/20 0.34
AKR1C3 P42330 2/20 0.33
GLA P06280 1/20 0.33
RECQL P46063 1/20 0.33
POLB P06746 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
NPC1 O15118 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
TP53 P04637 1/20 0.32
HTT P42858 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MCL1 Q07820 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Styrene SCHEMBL2929107 0.83 ALDH1A1 (0.48) ALDH1A1TSHRTDP1FBP1CYP3A4
SCHEMBL29993090 0.82 HTT (0.38) ALDH1A1TDP1CA12CA2CA9
Styrene SCHEMBL29152718 0.79 ALDH1A1 (0.61) ALDH1A1TSHRTDP1CA12CA2
Styrene SCHEMBL5959955 0.78 ALDH1A1 (0.67) ALDH1A1TSHRTDP1CA12CA2
Styrene SCHEMBL165374 0.78 ALDH1A1 (0.67) ALDH1A1TSHRTDP1CA12CA2
SCHEMBL127250 0.76
SCHEMBL38657516 0.76 MEN1 (0.35) ALDH1A1TSHRTDP1CA12CA2
Acrylic Acid SCHEMBL28549354 0.75 LMNA (0.40) ALDH1A1HSD17B10
Styrene SCHEMBL28479724 0.75 ALDH1A1 (0.56) ALDH1A1TSHRTDP1CA12CA2
Styrene SCHEMBL5960688 0.75 ALDH1A1 (0.61) ALDH1A1TSHRTDP1FBP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3801813-A1 CONTROLLING THE RHEOLOGY OF A METAL ORE RESIDUE Coatex (FR) 2021-04-14 EP claimed
EP-3801811-A2 METHOD FOR CONTROLLING THE SEDIMENTATION OF A MINING DERIVATIVE Coatex (FR) 2021-04-14 EP claimed
EP-3810299-A1 RECYCLING OF WATER IN A MINING BY-PRODUCT Coatex (FR) 2021-04-28 EP disclosed
EP-3801811-A2 METHOD FOR CONTROLLING THE SEDIMENTATION OF A MINING DERIVATIVE Coatex (FR) 2021-04-14 EP disclosed
EP-3801813-A1 CONTROLLING THE RHEOLOGY OF A METAL ORE RESIDUE Coatex (FR) 2021-04-14 EP disclosed