SCHEMBL2370540

SCHEMBL2370540

CC(C(=O)[O-])c1ncncc1F.CCOC(=O)C(C)c1ncncc1F.[Na+]

nearest known ligand 0.36

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.36
LMNA P02545 3/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CYP3A4 P08684 6/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2B6 P20813 1/20 0.35
CYP3A5 P20815 1/20 0.35
CYP3A7 P24462 1/20 0.35
MAPK1 P28482 1/20 0.35
CYP2C19 P33261 1/20 0.35
CYP3A43 Q9HB55 1/20 0.35
CYP46A1 Q9Y6A2 1/20 0.35
KMT2A Q03164 3/20 0.35
ALDH1A1 P00352 2/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
POLB P06746 2/20 0.32
GPR119 Q8TDV5 1/20 0.31
MAPT P10636 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2370256 0.92 TSHR (0.41) TSHRLMNASMN1; SMN2CYP3A4CYP2C9
SCHEMBL2370533 0.88 CYP3A4 (0.36) LMNACYP3A4CYP2C9CYP2B6CYP3A5
SCHEMBL2370196 0.88 CYP3A4 (0.36) LMNACYP3A4CYP2C9CYP2B6CYP3A5
SCHEMBL2371309 0.85 CYP3A4 (0.36) LMNACYP3A4CYP2C9CYP2B6CYP3A5
Potassium Ion SCHEMBL2370572 0.85 CYP3A4 (0.36) LMNACYP3A4CYP2C9CYP2B6CYP3A5
Lithium Ion SCHEMBL2370296 0.85 CYP3A4 (0.36) LMNACYP3A4CYP2C9CYP2B6CYP3A5
SCHEMBL2370494 0.79 MEN1 (0.39) LMNACYP3A4CYP2C9CYP2B6CYP3A5
SCHEMBL2371326 0.71 AKR1C3 (0.38) TSHRLMNACYP3A4CYP2C9CYP2B6
SCHEMBL30079271 0.68 TSHR (0.47) TSHRLMNASMN1; SMN2CYP2C9MAPK1
SCHEMBL9943519 0.67 CYP2C9 (0.41) LMNACYP2C9MAPK1CYP2C19ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2545039-A1 A PROCESS FOR MAKING VORICONAZOLE Synthon BV (NL) 2013-01-16 EP disclosed
WO-2011110198-A1 A PROCESS FOR MAKING VORICONAZOLE SYNTHRON B.V. (NL) 2011-09-15 WO disclosed