Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 9/20 | 0.59 |
| ▸ | THRA known ✓ | P10827 | 6/20 | 0.59 |
| ▸ | PPARG known ✓ | P37231 | 6/20 | 0.59 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 2/20 | 0.59 |
| ▸ | PDE4D known ✓ | Q08499 | 2/20 | 0.59 |
| ▸ | NR3C1 known ✓ | P04150 | 1/20 | 0.59 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.59 |
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.45 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.45 |
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.45 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.45 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.45 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.45 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.45 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.45 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30056620 | 1.00 | THRB (0.59) | THRBMEN1KMT2ATHRAPPARG | |
| SCHEMBL468893 | 0.88 | THRB (0.69) | THRBMEN1KMT2ATHRAPPARG | |
| SCHEMBL468892 | 0.88 | THRB (0.69) | THRBMEN1KMT2ATHRAPPARG | |
| Water SCHEMBL1526158 | 0.87 | THRB (0.57) | THRBMEN1KMT2ATHRAPPARG | |
| SCHEMBL10878152 | 0.87 | THRB (0.60) | THRBMEN1KMT2ATHRAPPARG | |
| SCHEMBL27294322 | 0.86 | THRB (0.59) | THRBMEN1KMT2ATHRAPPARG | |
| SCHEMBL10939002 | 0.85 | THRB (0.58) | THRBMEN1KMT2ATHRAPPARG | |
| SCHEMBL6723726 | 0.85 | THRB (0.58) | THRBMEN1KMT2ATHRAPPARG | |
| SCHEMBL6723723 | 0.85 | THRB (0.58) | THRBMEN1KMT2ATHRAPPARG | |
| SCHEMBL10939006 | 0.85 | THRB (0.58) | THRBMEN1KMT2ATHRAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111808011-B | High penetration composition and its application | 泰飞尔生物医药(苏州)有限公司 | 2024-02-27 | — | — | CN | disclosed |
| US-20230233516-A1 | HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS | TECHFIELDS PHARMA CO., LTD (CN) | 2023-07-27 | — | — | US | disclosed |
| US-11541029-B2 | High penetration compositions and their applications | TECHFIELDS PHARMA CO., LTD. (CN) | 2023-01-03 | — | — | US | disclosed |
| US-20110269689-A1 | HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS | PREMIER RESEARCH INTERNATIONAL, LLC | 2011-11-03 | — | — | US | disclosed |
| EP-2370406-A1 | HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS | Yu, Chongxi (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010065936-A1 | HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS | YU CHONGXI (US) | 2010-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269689-A1 | HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS | SLC19A1, HIRA, SLC43A1 | THRB 4053/4885THRA 2390/4885PPARG 2406/4885 |
| US-11541029-B2 | High penetration compositions and their applications | SLC19A1, HIRA, SLC43A1 | THRB 4053/4885THRA 2390/4885PPARG 2406/4885 |
| US-20230233516-A1 | HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS | SLC5A7, SLC19A1, SLC43A1 | THRB 3974/4885THRA 2496/4885PPARG 2315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.