Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 8/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 8/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Drofenine SCHEMBL446912 | 0.99 | CYP3A4 (1.00) | CHRM2CHRM1CYP3A4LMNACYP1A2 | |
| Drofenine SCHEMBL1649803 | 0.98 | CHRM2 (0.95) | CHRM2CHRM1CYP3A4LMNACYP1A2 | |
| SCHEMBL10955574 | 0.83 | SLC6A2 (0.70) | CHRM2CHRM1CYP3A4LMNACYP1A2 | |
| SCHEMBL28622583 | 0.82 | SLC6A2 (0.69) | CHRM2CHRM1CYP3A4LMNACYP1A2 | |
| SCHEMBL7489656 | 0.81 | SLC6A2 (0.68) | CHRM2CHRM1CYP3A4LMNACYP1A2 | |
| SCHEMBL28632940 | 0.81 | SLC6A2 (0.67) | CHRM2CHRM1CYP3A4LMNACYP1A2 | |
| SCHEMBL28622638 | 0.81 | SLC6A3 (0.67) | CHRM2CHRM1CYP3A4LMNACYP1A2 | |
| SCHEMBL28619401 | 0.80 | SLC6A2 (0.66) | CHRM2CHRM1CYP3A4LMNACYP1A2 | |
| SCHEMBL28637337 | 0.80 | SLC6A2 (0.66) | CHRM2CHRM1CYP3A4LMNACYP1A2 | |
| SCHEMBL28636471 | 0.80 | SLC6A2 (0.66) | CHRM2CHRM1CYP3A4LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 654 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12550885-B2 | Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells | UNIVERSITY OF CINCINNATI (US) | 2026-02-17 | — | — | US | claimed |
| EP-4658278-A1 | SELECTIVE FIASMA TREATMENT | Valo Health, Inc. (US) | 2025-12-10 | — | — | EP | claimed |
| WO-2024163699-A1 | SELECTIVE FIASMA TREATMENT | VALO HEALTH, INC. (US) | 2024-08-08 | — | — | WO | claimed |
| US-20230003721-A1 | MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2023-01-05 | — | — | US | claimed |
| US-20210235686-A1 | RED BLOOD CELL STORAGE SOLUTIONS, SOLUTION ADDITIVES, AND METHODS FOR IMPROVING THE STORAGE OF RED BLOOD CELLS | UNIVERSITY OF CINCINNATI | 2021-08-05 | — | — | US | claimed |
| US-20210000782-A1 | APPLICATION OF DROFENINE OR SALT THEREOF TO PREPARATION OF MEDICINE FOR TREATING PERIPHERAL NEURON AXONAL INJURY AND PERIPHERAL RELATED NEUROPATHY | Nanjing University of Chinese Medicine (CN) | 2021-01-07 | — | — | US | claimed |
| CN-109846874-A | The application of drofenine and its salt in the drug of the relevant neuropathy in preparation treatment and peripheral neurons axonal injury, periphery | 南京中医药大学 | 2019-06-07 | — | — | CN | claimed |
| CN-108186622-A | The application of drofenine and its pharmaceutically acceptable salt in the drug for treating Alzheimer disease is prepared | 南京中医药大学 | 2018-06-22 | — | — | CN | claimed |
| US-20150190377-A1 | NEURONAL REGENERATION | CHILDREN'S MEDICAL CENTER CORPORATION | 2015-07-09 | — | — | US | claimed |
| US-9016221-B2 | Surface topographies for non-toxic bioadhesion control | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-04-28 | — | — | US | claimed |
| EP-1273301-B1 | Pharmaceutical preparations based on active ingredients susceptible to illicit administration | ALTERGON SA (CH) | 2006-09-06 | — | — | EP | claimed |
| US-20060188445-A1 | Assay for compounds that protect against sensory hair cell death and compounds identified by same | FRED HUTCHINSON CANCER RESEARCH CENTER | 2006-08-24 | — | — | US | claimed |
| EP-1551370-A1 | AGGREGATE WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN | IDEA AG (DE) | 2005-07-13 | — | — | EP | claimed |
| US-20040105881-A1 | Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin | IDEA AG (DE) | 2004-06-03 | — | — | US | claimed |
| WO-2004032900-A1 | AGGREGATE WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN | IDEA AG (DE) | 2004-04-22 | — | — | WO | claimed |
| EP-1273301-A2 | Pharmaceutical preparations based on active ingredients susceptible to illicit administration | ALTERGON S.A. (CH) | 2003-01-08 | — | — | EP | claimed |
| EP-1014943-B1 | MEDICAL AEROSOL FORMULATIONS | JAGO RES AG (CH) | 2002-06-19 | — | — | EP | claimed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | claimed |
| EP-1073470-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2001-02-07 | — | — | EP | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060188445-A1 | Assay for compounds that protect against sensory hair cell death and compounds identified by same | AIFM1, CASP3, CASP10 | CHRM2 4776/4885CHRM1 4794/4885CYP3A4 4822/4885 |
| US-12550885-B2 | Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells | SMPD3, SMPD4, CMA1 | CHRM2 100/4885CHRM1 246/4885CYP3A4 173/4885 |
| US-20210000782-A1 | APPLICATION OF DROFENINE OR SALT THEREOF TO PREPARATION OF MEDICINE FOR TREATING PERIPHERAL NEURON AXONAL INJURY AND PERIPHERAL RELATED NEUROPATHY | BDNF, PMP22, NGF | CHRM2 2627/4885CHRM1 3686/4885CYP3A4 4678/4885 |
| US-20040105881-A1 | Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin | CUTA, ABCG2, PIGS | CHRM2 2986/4885CHRM1 3667/4885CYP3A4 1106/4885 |
| US-20150190377-A1 | NEURONAL REGENERATION | GAP43, DCX, BDNF | CHRM2 4375/4885CHRM1 4780/4885CYP3A4 4880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.