Sugi Predict

Sugi Predict / Compounds / SCHEMBL260779

SCHEMBL260779

SCHEMBL260779

N#Cc1cc(F)[c]c(F)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TTR P02766 2/20 0.37
▸ ALB P02768 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ VCAM1 P19320 2/20 0.34
▸ TSHR P16473 1/20 0.33
▸ TRPV4 Q9HBA0 1/20 0.32
▸ KIF11 P52732 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ CYP2A6 P11509 1/20 0.31
▸ CA12 O43570 1/20 0.31
▸ CA2 P00918 1/20 0.31
▸ CA3 P07451 1/20 0.31
▸ CA6 P23280 1/20 0.31
▸ CA9 Q16790 1/20 0.31
▸ CA14 Q9ULX7 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.30
▸ TP53 P04637 1/20 0.30
▸ GPR35 Q9HC97 1/20 0.30
▸ GRM5 P41594 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1708531 0.84 VCAM1 (0.34) TTRALBMEN1KMT2AVCAM1
SCHEMBL28945808 0.80 KIF11 (0.36) TRPV4KIF11
SCHEMBL17514949 0.80 EGLN2 (0.36) KIF11
SCHEMBL17514859 0.74 EGLN2 (0.35) —
SCHEMBL60145 0.71 TTR (0.50) TTRALBMEN1KMT2AVCAM1
SCHEMBL56741 0.71 GRM5 (0.43) TTRALBMEN1KMT2AGRM5
SCHEMBL1421650 0.71 GRM5 (0.47) GRM5
SCHEMBL184366 0.70 — —
SCHEMBL1026277 0.69 — —
SCHEMBL157603 0.69 CES2 (0.42) TTRALBMEN1KMT2AVCAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427426-B1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-02-07 — — EP claimed
WO-2013055910-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2013-04-18 — — WO claimed
US-8133847-B2 Pyrido[2,3-B]pyrazine derivatives useful as herbicidal compounds SYNGENTA LIMITED (GB) 2012-03-13 — — US claimed
US-20100144674-A1 PYRIDAZINE DERIVATIVES SYNGENTA CROP PROTECTION, INC. (US) 2010-06-10 — — US claimed
US-20100113457-A1 NOVEL PYRIDAZINE DERIVATIVES SYNGENTA CROP PROTECTION, INC. (US) 2010-05-06 — — US claimed
US-20100022526-A1 PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-01-28 — — US claimed
US-20090305892-A1 PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2009-12-10 — — US claimed
EP-2121628-A1 PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES Syngenta Participations AG (CH) 2009-11-25 — — EP claimed
EP-2121629-A1 NOVEL PYRIDAZINE DERIVATIVES Syngeta Participations AG (CH) 2009-11-25 — — EP claimed
US-20090270383-A1 Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias ASTRAZENECA AB (SE) 2009-10-29 — — US claimed
WO-2008089934-A1 PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES SYNGENTA PARTICIPATIONS AG (CH) 2008-07-31 — — WO claimed
US-7402589-B2 Tri-substituted ureas as cytokine inhibitors THE PROCTER & GAMBLE COMPANY (US) 2008-07-22 — — US claimed
WO-2008049585-A1 PYRIDAZINE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2008-05-02 — — WO claimed
WO-2008049584-A1 NOVEL PYRIDAZINE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2008-05-02 — — WO claimed
WO-2008009908-A1 PYRIDO [2, 3-B] PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2008-01-24 — — WO claimed
WO-2007149873-A2 KV1.5 POTASSIUM CHANNEL INHIBITORS WYETH (US) 2007-12-27 — — WO claimed
US-20070299072-A1 KV1.5 POTASSIUM CHANNEL INHIBITORS WYETH (US) 2007-12-27 — — US claimed
EP-1737830-A1 TRI-SUBSTITUTED UREAS AS CYTOKINE INHIBITORS The Procter and Gamble Company (US) 2007-01-03 — — EP claimed
WO-2005105757-A1 TRI-SUBSTITUTED UREAS AS CYTOKINE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 2005-11-10 — — WO claimed
US-20050245555-A1 Tri-substituted ureas as cytokine inhibitors THE PROCTER & GAMBLE COMPANY (US) 2005-11-03 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050245555-A1 Tri-substituted ureas as cytokine inhibitors IL1B, IL1A, IL6 TTR 1133/4885ALB 2030/4885MEN1 3574/4885
US-20090270383-A1 Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias KCNH1, RYR1, CACNA1E TTR 662/4885ALB 3631/4885MEN1 2587/4885
US-20070299072-A1 KV1.5 POTASSIUM CHANNEL INHIBITORS KCNA5, KCNH1, KCNK5 TTR 2324/4885ALB 4867/4885MEN1 3529/4885
US-20100113457-A1 NOVEL PYRIDAZINE DERIVATIVES C3AR1, C5, C1S TTR 3685/4885ALB 4476/4885MEN1 2370/4885
US-20100022526-A1 PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES CYP4Z1, CYP1A2, CYP1A1 TTR 1367/4885ALB 4125/4885MEN1 287/4885
US-20100144674-A1 PYRIDAZINE DERIVATIVES C3AR1, C1S, CBR3 TTR 2375/4885ALB 4579/4885MEN1 4260/4885
US-20090305892-A1 PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS PNPO, CBR3, CBR1 TTR 3877/4885ALB 4161/4885MEN1 3617/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.