SCHEMBL2616751

SCHEMBL2616751

CO[Si](CCCNC(=O)CCC(=O)O)(OC)OC

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.46
POLB P06746 1/20 0.41
EPHX2 P34913 3/20 0.40
CASP2 P42575 1/20 0.39
ADRA1A P35348 1/20 0.39
KDM4E B2RXH2 3/20 0.39
LMNA P02545 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
KDM5C P41229 2/20 0.38
EGLN1 Q9GZT9 2/20 0.38
PHF8 Q9UPP1 2/20 0.38
KDM2A Q9Y2K7 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
MAPT P10636 1/20 0.38
SLC6A5 Q9Y345 1/20 0.38
HPGD P15428 1/20 0.38
KDM6B O15054 1/20 0.38
FOLH1 Q04609 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22174072 0.93 TSHR (0.52) TSHRPOLBCASP2KDM4ELMNA
SCHEMBL24844352 0.90 EPHX2 (0.51) TSHRPOLBEPHX2ADRA1AKDM4E
SCHEMBL18164189 0.87 TSHR (0.55) TSHRPOLBCASP2MEN1KMT2A
SCHEMBL2616753 0.84 TSHR (0.44) TSHRPOLBEPHX2CASP2ADRA1A
SCHEMBL29962269 0.84 TSHR (0.44) TSHRPOLBCASP2KDM4ELMNA
SCHEMBL19083849 0.84 CASP2 (0.58) TSHRCASP2
SCHEMBL31074224 0.84 TSHR (0.52) TSHRPOLBEPHX2CASP2
SCHEMBL2616692 0.83 EPHX2 (0.41) TSHREPHX2CASP2ADRA1AKDM4E
SCHEMBL18180992 0.83 TSHR (0.44) TSHRPOLBCASP2KDM4EMEN1
SCHEMBL16907942 0.82 TSHR (0.50) TSHRPOLBCASP2LMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210292598-A1 TRANSPARENT ELASTOMERIC NANOCOMPOSITE BLENDS 3M INNOVATIVE PROPERTIES COMPANY 2021-09-23 US disclosed
US-20210163716-A1 TRANSPARENT ELASTOMERIC NANOCOMPOSITES 3M INNOVATIVE PROPERTIES COMPANY 2021-06-03 US disclosed
CN-109749671-B Acrylate pressure-sensitive adhesive containing nano siloxane condensate, adhesive sheet and preparation method thereof 3M创新有限公司 2020-12-08 CN disclosed
US-8492071-B2 Curable composition, color filter and process for production thereof, and solid-state imaging device FUJIFILM CORPORATION (JP) 2013-07-23 US disclosed
US-8456733-B2 Coloured particles for electrophoretic displays BASF SE (DE) 2013-06-04 US disclosed
US-20130078390-A1 METHODS AND PROCESSES FOR ATTACHING COMPOUNDS TO MATRICES SPRING BANK PHARMACEUTICALS, INC. (US) 2013-03-28 US disclosed
US-8287700-B2 Methods and processes for attaching compounds to matrices SPRING BANK (US) 2012-10-16 US disclosed
US-8182968-B2 Color filter and method for producing the same FUJIFILM CORPORATION (JP) 2012-05-22 US disclosed
US-8158307-B2 Forming first color pattern in repeating pattern on substrate; forming second color pattern on substrate; removal by dry etching; forming third color pattern FUJIFILM CORPORATION (JP) 2012-04-17 US disclosed
US-8147802-B2 Chelator-functionalized nanoparticles GENERAL ELECTRIC COMPANY (US) 2012-04-03 US disclosed
US-20110028587-A1 CURABLE COMPOSITION, COLOR FILTER AND PROCESS FOR PRODUCTION THEREOF, AND SOLID-STATE IMAGING DEVICE FUJIFILM CORPORATION (JP) 2011-02-03 US disclosed
US-20100178512-A1 CHANGING SURFACE PROPERTIES BY FUNCTIONALIZED NANOPARTICLES CIBA CORPORATION (US) 2010-07-15 US disclosed
US-20100096251-A1 Methods and Processes for Attaching Compounds to Matrices PADMANABHAN SEETHARAMAIYER 2010-04-22 US disclosed
US-20090296195-A1 Coloured Particles for Electrophoretic Displays BASF SE (DE) 2009-12-03 US disclosed
US-20090099282-A1 Functionalized nanoparticles CIBA SPECIALTY CHEMICALS CORP. 2009-04-16 US disclosed
US-20090087381-A1 CHELATOR-FUNCTIONALIZED NANOPARTICLES GENERAL ELECTRIC COMPANY (US) 2009-04-02 US disclosed
US-20080286665-A1 COLOR FILTER AND METHOD FOR PRODUCING THE SAME FUJIFILM CORPORATION (JP) 2008-11-20 US disclosed
US-20080206659-A1 COLOR FILTER AND METHOD OF MANUFACTURING THE SAME, AND SOLID-STATE IMAGE PICKUP ELEMENT FUJIFILM CORPORATION (JP) 2008-08-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210292598-A1 TRANSPARENT ELASTOMERIC NANOCOMPOSITE BLENDS TTN, AS3MT, PTN TSHR 3022/4885POLB 2154/4885EPHX2 3616/4885
US-20090296195-A1 Coloured Particles for Electrophoretic Displays RAB5IF, IK, AOX1 TSHR 3308/4885POLB 440/4885EPHX2 877/4885
US-20090087381-A1 CHELATOR-FUNCTIONALIZED NANOPARTICLES SLC40A1, TFRC, SLC19A1 TSHR 1875/4885POLB 3497/4885EPHX2 3918/4885
US-20100096251-A1 Methods and Processes for Attaching Compounds to Matrices STUB1, PTMS, MRE11 TSHR 1715/4885POLB 552/4885EPHX2 2376/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.