Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.83 |
| ▸ | HPGD | P15428 | 4/20 | 0.83 |
| ▸ | NPC1 | O15118 | 3/20 | 0.83 |
| ▸ | RAB9A | P51151 | 3/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.83 |
| ▸ | TP53 | P04637 | 2/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.83 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.83 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.83 |
| ▸ | PKM | P14618 | 2/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.83 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.83 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.83 |
| ▸ | HPGDS | O60760 | 1/20 | 0.83 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2783104 | 1.00 | MEN1 (0.83) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| Tranilast SCHEMBL30352530 | 0.91 | MEN1 (1.00) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| Tranilast SCHEMBL29366319 | 0.91 | MEN1 (1.00) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| Tranilast SCHEMBL30053800 | 0.91 | MEN1 (1.00) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| Tranilast SCHEMBL29875 | 0.91 | MEN1 (1.00) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| Tranilast SCHEMBL10978582 | 0.91 | MEN1 (1.00) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| Tranilast SCHEMBL8696829 | 0.91 | MEN1 (1.00) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| Tranilast SCHEMBL29876 | 0.91 | MEN1 (1.00) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| Tranilast SCHEMBL29556872 | 0.91 | MEN1 (1.00) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL21024834 | 0.90 | MEN1 (0.70) | MEN1KMT2AALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160351-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING HYPERURICEMIA AND RELATED DISORDERS | NUON THERAPEUTICS, INC. (US) | 2010-06-24 | — | — | US | claimed |
| EP-2173167-A2 | TREATMENT OF NEUROPATHIC PAIN | Nuon Therapeutics, Inc. (US) | 2010-04-14 | — | — | EP | claimed |
| US-20100041756-A1 | METHOD OF MODULATING B CELL FUNCTIONING | IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY & MEDICINE (GB) | 2010-02-18 | — | — | US | claimed |
| US-20090312422-A1 | METHOD OF MODULATING CELLULAR ACTIVITY AND AGENTS USEFUL FOR SAME | EBERHARD-KARLS-UNIVERSITAET TUEBINGEN UNIVERSITAETSKLINIKUM | 2009-12-17 | — | — | US | claimed |
| US-20090197957-A1 | Methods and compositions for the treatment of pain | NUON THERAPEUTICS, INC. | 2009-08-06 | — | — | US | claimed |
| US-20090042987-A1 | TREATMENT OF NEUROPATHIC PAIN | NUON THERAPEUTICS INC. | 2009-02-12 | — | — | US | claimed |
| WO-2009008997-A2 | TREATMENT OF NEUROPATHIC PAIN | NUON THERAPEUTICS, INC. (US) | 2009-01-15 | — | — | WO | claimed |
| US-20080103204-A1 | Method of modulating cellular activity and agents useful for same | EBERHARD-KARLS-UNIVERSITAT TUBINGEN (DE) | 2008-05-01 | — | — | US | claimed |
| US-20080009519-A1 | METHOD OF MODULATING T CELL FUNCTIONING | ANGIOGEN PHARMACEUTICALS PTY LIMITED (AU) | 2008-01-10 | — | — | US | claimed |
| WO-2018144620-A9 | ANTI-FIBROTIC COMPOUNDS | CERTA THERAPEUTICS PTY LTD. (AU) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018144620-A1 | ANTI-FIBROTIC COMPOUNDS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2018-08-09 | — | — | WO | disclosed |
| US-9561201-B2 | Therapeutic compounds | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2017-02-07 | — | — | US | disclosed |
| US-20120022116-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX | CORNING INCORPORATED | 2012-01-26 | — | — | US | disclosed |
| WO-2011047432-A1 | FUSED RING ANALOGUES OF ANTI-FIBROTIC AGENTS | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2011-04-28 | — | — | WO | disclosed |
| US-20090197957-A1 | Methods and compositions for the treatment of pain | NUON THERAPEUTICS, INC. | 2009-08-06 | — | — | US | disclosed |
| US-7531575-B2 | Method of modulating cellular activity and agents useful for same | Eberhard-Karls-Universität Tübingin (DE) | 2009-05-12 | — | — | US | disclosed |
| US-20090042987-A1 | TREATMENT OF NEUROPATHIC PAIN | NUON THERAPEUTICS INC. | 2009-02-12 | — | — | US | disclosed |
| WO-2009008997-A2 | TREATMENT OF NEUROPATHIC PAIN | NUON THERAPEUTICS, INC. (US) | 2009-01-15 | — | — | WO | disclosed |
| US-20080103204-A1 | Method of modulating cellular activity and agents useful for same | EBERHARD-KARLS-UNIVERSITAT TUBINGEN (DE) | 2008-05-01 | — | — | US | disclosed |
| US-20080009519-A1 | METHOD OF MODULATING T CELL FUNCTIONING | ANGIOGEN PHARMACEUTICALS PTY LIMITED (AU) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103204-A1 | Method of modulating cellular activity and agents useful for same | NLN, GAP43, CYBB | MEN1 3828/4885KMT2A 3579/4885ALDH1A1 1430/4885 |
| US-20120022116-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX | GPR35, GPR65, GPR68 | MEN1 4026/4885KMT2A 4109/4885ALDH1A1 1572/4885 |
| US-20100160351-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING HYPERURICEMIA AND RELATED DISORDERS | XDH, SLC10A1, SLC10A6 | MEN1 1944/4885KMT2A 3365/4885ALDH1A1 488/4885 |
| US-20080009519-A1 | METHOD OF MODULATING T CELL FUNCTIONING | IFNG, CD4, IDO1 | MEN1 3959/4885KMT2A 1759/4885ALDH1A1 1352/4885 |
| US-20090197957-A1 | Methods and compositions for the treatment of pain | OPRL1, OPRK1, ACHE | MEN1 3723/4885KMT2A 1934/4885ALDH1A1 312/4885 |
| US-20090042987-A1 | TREATMENT OF NEUROPATHIC PAIN | OPRL1, GAP43, AANAT | MEN1 3473/4885KMT2A 1821/4885ALDH1A1 1131/4885 |
| US-20100041756-A1 | METHOD OF MODULATING B CELL FUNCTIONING | KYNU, IDO1, IDO2 | MEN1 3204/4885KMT2A 1427/4885ALDH1A1 1104/4885 |
| US-20090312422-A1 | METHOD OF MODULATING CELLULAR ACTIVITY AND AGENTS USEFUL FOR SAME | NLN, GAP43, CYBB | MEN1 3828/4885KMT2A 3579/4885ALDH1A1 1430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.