SCHEMBL2785654

SCHEMBL2785654

Cc1nc(-c2ccc(-c3cccnc3)s2)sc1C(=O)[O-].[Na+]

nearest known ligand 0.60

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRAF known ✓ P15056 2/20 0.45
CYP3A4 P08684 7/20 0.60
CYP2C19 P33261 7/20 0.60
CYP1A2 P05177 4/20 0.60
LMNA P02545 1/20 0.60
CYP2C9 P11712 5/20 0.50
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
CYP2D6 P10635 3/20 0.50
CYP2A6 P11509 5/20 0.49
MAPT P10636 2/20 0.47
MKNK1 Q9BUB5 1/20 0.47
MKNK2 Q9HBH9 1/20 0.47
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC10 Q969S8 1/20 0.45
HDAC11 Q96DB2 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL289321 0.87 CYP3A4 (0.62) CYP3A4CYP2C19CYP1A2LMNACYP2C9
SCHEMBL289879 0.87 CYP3A4 (0.62) CYP3A4CYP2C19CYP1A2LMNACYP2C9
Hydrochloric Acid SCHEMBL289747 0.86 CYP3A4 (0.61) CYP3A4CYP2C19CYP1A2LMNACYP2C9
SCHEMBL289784 0.82 CDC7 (0.62) CYP3A4CYP2C19CYP1A2LMNACYP2C9
Hydrochloric Acid SCHEMBL289783 0.81 CDC7 (0.61) CYP3A4CYP2C19CYP1A2LMNACYP2C9
SCHEMBL595294 0.76 CYP1A2 (0.77) CYP3A4CYP2C19CYP1A2LMNACYP2C9
SCHEMBL29783018 0.76 CYP3A4 (0.77) CYP3A4CYP2C19CYP1A2LMNACYP2C9
SCHEMBL1574577 0.76 CYP3A4 (0.77) CYP3A4CYP2C19CYP1A2LMNACYP2C9
Hydrochloric Acid SCHEMBL11388179 0.75 CYP1A2 (0.75) CYP3A4CYP2C19CYP1A2LMNACYP2C9
SCHEMBL5211666 0.75 CYP1A2 (1.00) CYP3A4CYP2C19CYP1A2LMNACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010128163-A2 SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION PIKE PHARMA GMBH (CH) 2010-11-11 WO disclosed