SCHEMBL2808430

SCHEMBL2808430

O=C(O)c1ccc2oc3cccc(C(=O)O)c3c(=O)c2c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 11/20 0.72
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51
AKR1B1 P15121 1/20 0.50
KDM4E B2RXH2 1/20 0.49
MEN1 O00255 1/20 0.49
ALDH1A1 P00352 1/20 0.49
TP53 P04637 1/20 0.49
CYP2C9 P11712 1/20 0.49
HPGD P15428 1/20 0.49
PTGER1 P34995 1/20 0.49
PTGER3 P43115 1/20 0.49
PTGER2 P43116 1/20 0.49
KMT2A Q03164 1/20 0.49
PTGDR Q13258 1/20 0.49
HSD17B10 Q99714 1/20 0.49
TBK1 Q9UHD2 2/20 0.48
PTPN1 P18031 1/20 0.46
MAOA P21397 1/20 0.43
IKBKE Q14164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29415448 1.00 TTR (0.72) TTRNPC1RAB9AAKR1B1KDM4E
SCHEMBL7550966 0.84 KDM4E (0.55) TTRNPC1RAB9AKDM4EMEN1
SCHEMBL1987428 0.83 MAOA (0.62) TTRKDM4EMEN1ALDH1A1HPGD
SCHEMBL68189 0.82 TTR (0.83) TTRNPC1RAB9AAKR1B1KDM4E
SCHEMBL1787556 0.81 TTR (1.00) TTRNPC1RAB9AAKR1B1KDM4E
SCHEMBL11749385 0.81 TTR (0.67) TTRNPC1RAB9AAKR1B1KDM4E
SCHEMBL11319747 0.81 TTR (0.73) TTRNPC1RAB9AAKR1B1KDM4E
Hydrochloric Acid SCHEMBL11749391 0.81 TTR (0.81) TTRNPC1RAB9AAKR1B1KDM4E
SCHEMBL70977 0.81 HSD17B10 (0.48) TTRKDM4EALDH1A1HPGDHSD17B10
Hydrochloric Acid SCHEMBL11367851 0.80 TTR (0.97) TTRNPC1RAB9AAKR1B1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8968711-B2 Cosmetic or dermatological composition comprising a polymer bearing junction groups, and cosmetic treatment process L'OREAL (FR) 2015-03-03 US claimed
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT L'OREAL (FR) 2010-10-28 US claimed
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS L'OREAL (FR) 2010-09-23 US claimed
CN-116322616-A Hair lightening compositions providing damage protection and sensory benefits and methods of use 欧莱雅 2023-06-23 CN disclosed
US-11559474-B2 Hair lightening compositions and methods of use L'OREAL (FR) 2023-01-24 US disclosed
US-8968711-B2 Cosmetic or dermatological composition comprising a polymer bearing junction groups, and cosmetic treatment process L'OREAL (FR) 2015-03-03 US disclosed
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT L'OREAL (FR) 2010-10-28 US disclosed
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS L'OREAL (FR) 2010-09-23 US disclosed
US-20090028807-A1 COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION L'OREAL (FR) 2009-01-29 US disclosed
US-4250182-A Pharmaceutical composition containing acridone compounds and method of using same BURROUGHS WELLCOME CO. (US) 1981-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS CUTA, SUCLG1, KRT18 TTR 4726/4885NPC1 4765/4885RAB9A 4090/4885
US-20090028807-A1 COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION CUTA, SYMPK, TPRKB TTR 1505/4885NPC1 3829/4885RAB9A 4503/4885
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT ACMSD, CUTA, PCCA TTR 4391/4885NPC1 3993/4885RAB9A 4824/4885
US-11559474-B2 Hair lightening compositions and methods of use TYR, ALAD, CYBA TTR 1397/4885NPC1 4854/4885RAB9A 4315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.