Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2851002 | 0.91 | SMN1; SMN2 (0.53) | ALDH1A1HTTSMN1; SMN2POLBKMT2A | |
| SCHEMBL2857766 | 0.90 | ALDH1A1 (0.56) | ALDH1A1HTTSMN1; SMN2TSHRKDM4E | |
| SCHEMBL2848518 | 0.86 | ALDH1A1 (0.58) | ALDH1A1HTTSMN1; SMN2TSHRKDM4E | |
| SCHEMBL2861261 | 0.83 | HPGD (0.64) | ALDH1A1SMN1; SMN2POLBLMNAGAA | |
| SCHEMBL2858313 | 0.82 | P2RX7 (0.56) | ALDH1A1SMN1; SMN2TSHRLMNAGAA | |
| SCHEMBL2854337 | 0.81 | HPGD (0.53) | ALDH1A1SMN1; SMN2POLBLMNAHPGD | |
| SCHEMBL2853267 | 0.81 | HPGD (0.55) | ALDH1A1SMN1; SMN2LMNAHPGDMAPK1 | |
| SCHEMBL2852334 | 0.81 | HPGD (0.55) | ALDH1A1SMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL2856865 | 0.78 | L3MBTL1 (0.51) | ALDH1A1HTTSMN1; SMN2TSHRKDM4E | |
| SCHEMBL2854686 | 0.78 | SMN1; SMN2 (0.52) | ALDH1A1HTTSMN1; SMN2TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |