Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912963 | 0.84 | ALDH1A1 (0.42) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL1530825 | 0.83 | AURKB (0.46) | NPC1RAB9AHTTPOLBPABPC1 | |
| SCHEMBL2913166 | 0.80 | XDH (0.38) | NPC1RAB9AHTTMEN1KMT2A | |
| SCHEMBL2908073 | 0.80 | NR1H4 (0.47) | MEN1KMT2A | |
| SCHEMBL2910962 | 0.79 | RAB9A (0.39) | NPC1RAB9AHTTPOLBMEN1 | |
| SCHEMBL2913446 | 0.79 | ALDH1A1 (0.36) | NPC1RAB9AHTTPOLBMEN1 | |
| SCHEMBL2910190 | 0.79 | GPR27 (0.42) | MEN1KMT2A | |
| SCHEMBL2906969 | 0.79 | ALDH1A1 (0.36) | NPC1RAB9AHTTPOLBMEN1 | |
| SCHEMBL2910683 | 0.78 | ALDH1A1 (0.36) | RAB9AMAPTALDH1A1 | |
| SCHEMBL2915626 | 0.78 | ITGA4 (0.34) | NPC1RAB9AHTTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |