Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.43 |
| ▸ | CA2 | P00918 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | USP2 | O75604 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CFTR | P13569 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910291 | 0.92 | CNR2 (0.38) | KDM4ERAB9AKMT2AMEN1HTT | |
| SCHEMBL2908364 | 0.89 | CA2 (0.41) | CA1CA2KDM4EUSP2NPC1 | |
| SCHEMBL2912963 | 0.84 | ALDH1A1 (0.42) | NPC1RAB9AKMT2AMEN1LMNA | |
| SCHEMBL2913200 | 0.81 | KDM4E (0.40) | KDM4EUSP2KMT2AMEN1HTT | |
| SCHEMBL1530379 | 0.80 | CA1 (0.43) | CA1CA2KDM4EUSP2NPC1 | |
| SCHEMBL2910190 | 0.80 | GPR27 (0.42) | KMT2AMEN1 | |
| SCHEMBL2913166 | 0.80 | XDH (0.38) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL2913446 | 0.79 | ALDH1A1 (0.36) | NPC1RAB9AKMT2AMEN1HTT | |
| SCHEMBL2913374 | 0.78 | BCL2L1 (0.36) | CA1CA2ALDH1A1CFTRCA9 | |
| SCHEMBL2907837 | 0.78 | KDM4E (0.41) | KDM4ENPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |