Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20969942 | 0.72 | PPARA (0.40) | PPARA | |
| SCHEMBL15748053 | 0.70 | — | — | |
| SCHEMBL12131262 | 0.67 | — | — | |
| SCHEMBL569596 | 0.64 | — | — | |
| SCHEMBL21233172 | 0.62 | ALDH1A1 (0.36) | — | |
| SCHEMBL13184124 | 0.60 | APOBEC3G (0.43) | — | |
| SCHEMBL21547856 | 0.59 | — | — | |
| SCHEMBL21547877 | 0.59 | L3MBTL1 (0.42) | — | |
| SCHEMBL20031405 | 0.59 | PPARA (0.36) | TYK2PPARA | |
| SCHEMBL21408699 | 0.59 | PPARA (0.46) | TYK2PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662159-B2 | ABHD6 and dual ABHD6/MGL inhibitors and their uses | MAKSCIENTIFIC, LLC (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190152917-A1 | ABHD6 AND DUAL ABHD6/MGL INHIBITORS AND THEIR USES | MAKSCIENTIFIC, LLC | 2019-05-23 | — | — | US | disclosed |
| US-20100204245-A1 | Amino-pyridines As Inhibitors Of Beta-secretase | WYETH LLC (US) | 2010-08-12 | — | — | US | disclosed |
| US-20100168106-A1 | Amino-5-(5-membered)heteroarylimidazolone Compounds And The Use Thereof For Beta-secretase Modulation | WYETH LLC (US) | 2010-07-01 | — | — | US | disclosed |
| US-7732457-B2 | Amino-pyridines as inhibitors of β-secretase | WYETH LLC (US) | 2010-06-08 | — | — | US | disclosed |
| US-7705030-B2 | Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation | WYETH LLC (US) | 2010-04-27 | — | — | US | disclosed |
| US-7601847-B2 | Via lithium bis(trimethylsilyl)amide, lithium dicyclohexylamide, or potassium bis(trimethylsilyl)amide base and alkylating agent; atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, multiple sclerosis and rheumatoid arthritis | WYETH (US) | 2009-10-13 | — | — | US | disclosed |
| US-7585871-B2 | 4-{[(6R)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; 3-{[(6S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; 4-{[(6S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; cytokine expression | WYETH (US) | 2009-09-08 | — | — | US | disclosed |
| US-20090042908-A1 | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR BETA-SECRETASE MODULATION | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| EP-1542976-B1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH CORP (US) | 2009-02-04 | — | — | EP | disclosed |
| US-20060173049-A1 | enzyme inhibitors such as 6-{2-(2-Chloro-phenyl)-5-[4-(pyrimidin-2-yloxy)-phenyl]pyrrol-1-ylmethyl}-pyridin-2-ylamine, used to treat beta-amyloid deposits and neurofibrillary tangles; Alzheimer's disease | WYETH (US) | 2006-08-03 | — | — | US | disclosed |
| US-20060111574-A1 | Preparation and purification of 4-(indazol-3-yl) phenols | WYETH (US) | 2006-05-25 | — | — | US | disclosed |
| US-20060058337-A1 | Phenanthridine carbonyl phenols | WYETH (US) | 2006-03-16 | — | — | US | disclosed |
| WO-2006028875-A1 | PHENANTHRIDINE CARBONYL PHENOLS AS CYTOKINE MODULATORS | WYETH (US) | 2006-03-16 | — | — | WO | disclosed |
| WO-2005123664-A2 | PROCESSES FOR THE PREPARATION OF 2-CYANO-3-NAPHTHALENE-1-YL-ACRYLIC ACID ALKYL OR BENZYL ESTERS | WYETH (US) | 2005-12-29 | — | — | WO | disclosed |
| US-20050277783-A1 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-3-phenyl-propionic acid alkyl or benzyl esters | WYETH (US) | 2005-12-15 | — | — | US | disclosed |
| US-20050277784-A1 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-acrylic acid alkyl or benzyl esters | WYETH (US) | 2005-12-15 | — | — | US | disclosed |
| US-20050256132-A1 | Use of ER selective NF-kB inhibitors for the treatment of sepsis | WYETH (US) | 2005-11-17 | — | — | US | disclosed |
| US-20050004164-A1 | 2-Cyanopropanoic acid amide and ester derivatives and methods of their use | WYETH | 2005-01-06 | — | — | US | disclosed |
| US-20040167127-A1 | Substituted 4-(indazol-3-yl)phenols | WYETH (US) | 2004-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277783-A1 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-3-phenyl-propionic acid alkyl or benzyl esters | PCCA, PAH, CYP7A1 | TYK2 1317/4885PPARA 107/4885 |
| US-20050256132-A1 | Use of ER selective NF-kB inhibitors for the treatment of sepsis | NFKBIA, IKBKB, NFKB2 | TYK2 3006/4885PPARA 1127/4885 |
| US-10662159-B2 | ABHD6 and dual ABHD6/MGL inhibitors and their uses | ABHD6, FAAH, FAAH2 | TYK2 4639/4885PPARA 2217/4885 |
| US-20040167127-A1 | Substituted 4-(indazol-3-yl)phenols | INSR, MSR1, TNNI3 | TYK2 123/4885PPARA 1241/4885 |
| US-20090042908-A1 | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR BETA-SECRETASE MODULATION | BACE1, BACE2, APP | TYK2 4259/4885PPARA 4019/4885 |
| US-20050277784-A1 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-acrylic acid alkyl or benzyl esters | TNF, ACACA, PCCA | TYK2 962/4885PPARA 471/4885 |
| US-20190152917-A1 | ABHD6 AND DUAL ABHD6/MGL INHIBITORS AND THEIR USES | ABHD6, FAAH, FAAH2 | TYK2 4639/4885PPARA 2217/4885 |
| US-20100204245-A1 | Amino-pyridines As Inhibitors Of Beta-secretase | BACE1, BACE2, APP | TYK2 4033/4885PPARA 2792/4885 |
| US-20060058337-A1 | Phenanthridine carbonyl phenols | MT-CO2, PAH, CBR3 | TYK2 1151/4885PPARA 919/4885 |
| US-20060173049-A1 | enzyme inhibitors such as 6-{2-(2-Chloro-phenyl)-5-[4-(pyrimidin-2-yloxy)-phenyl]pyrrol-1-ylmethyl}-pyridin-2-ylamine, used to treat beta-amyloid deposits and neurofibrillary tangles; Alzheimer's disease | BACE1, BACE2, PSEN1 | TYK2 2739/4885PPARA 1578/4885 |
| US-20050004164-A1 | 2-Cyanopropanoic acid amide and ester derivatives and methods of their use | HCAR2, PCCA, MCCC2 | TYK2 2346/4885PPARA 258/4885 |
| US-20060111574-A1 | Preparation and purification of 4-(indazol-3-yl) phenols | H1-10, KCNH3, H1-0 | TYK2 466/4885PPARA 4116/4885 |
| US-20100168106-A1 | Amino-5-(5-membered)heteroarylimidazolone Compounds And The Use Thereof For Beta-secretase Modulation | BACE1, BACE2, APP | TYK2 4230/4885PPARA 4043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.