Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | MLYCD | O95822 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5703500 | 0.89 | HPGD (0.73) | HPGDALDH1A1MAPTMLYCDLMNA | |
| SCHEMBL12459651 | 0.87 | HPGD (0.49) | HPGDALDH1A1MAPTMLYCDLMNA | |
| SCHEMBL3944356 | 0.87 | PHLPP2 (0.53) | HPGDALDH1A1MAPTMLYCDLMNA | |
| SCHEMBL7377001 | 0.84 | HPGD (0.61) | HPGDALDH1A1MAPTMLYCDLMNA | |
| SCHEMBL10777907 | 0.84 | MLYCD (0.62) | HPGDALDH1A1MLYCDLMNACYP1A2 | |
| SCHEMBL4481559 | 0.83 | LMNA (0.58) | HPGDALDH1A1MAPTMLYCDLMNA | |
| SCHEMBL1018549 | 0.83 | HPGD (0.61) | HPGDALDH1A1MAPTMLYCDLMNA | |
| SCHEMBL14403407 | 0.83 | MLYCD (0.68) | HPGDALDH1A1MAPTMLYCDLMNA | |
| SCHEMBL25526179 | 0.82 | LMNA (0.48) | HPGDALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL10388616 | 0.81 | EGFR (0.60) | HPGDALDH1A1MAPTMLYCDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234377-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | EVOTEC AG (DE) | 2010-09-16 | — | — | US | claimed |
| EP-2150532-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | Evotec AG (DE) | 2010-02-10 | — | — | EP | claimed |
| WO-2008122787-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | EVOTEC AG (DE) | 2008-10-16 | — | — | WO | claimed |
| US-20060110743-A1 | Drug evolution: drug design at hot spots | KONISHI YASUO | 2006-05-25 | — | — | US | claimed |
| WO-2002095393-A2 | DRUG EVOLUTION: DRUG DESIGN AT HOT SPOTS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2002-11-28 | — | — | WO | claimed |
| EP-3946460-B1 | IMPROVED CONJUGATION LINKERS | PROLYNX LLC (US) | 2026-05-20 | — | — | EP | disclosed |
| US-20260007768-A1 | CONJUGATION LINKERS | PROLYNX LLC (US) | 2026-01-08 | — | — | US | disclosed |
| US-12364771-B2 | Conjugation linkers | PROLYNX LLC (US) | 2025-07-22 | — | — | US | disclosed |
| CN-119970617-A | Improved coupling joint | 普罗林科斯有限责任公司 | 2025-05-13 | — | — | CN | disclosed |
| US-12281060-B2 | Remodilins for airway remodeling and organ fibrosis | THE UNIVERSITY OF CHICAGO (US) | 2025-04-22 | — | — | US | disclosed |
| US-20240415851-A1 | REMODILINS TO PREVENT OR TREAT CANCER METASTASIS, GLAUCOMA, AND HYPOXIA | THE UNIVERSITY OF CHICAGO (US) | 2024-12-19 | — | — | US | disclosed |
| EP-3592746-B1 | TYK2 INHIBITORS, USES, AND METHODS FOR PRODUCTION THEREOF | TAKEDA PHARMACEUTICALS CO (JP) | 2024-01-24 | — | — | EP | disclosed |
| US-4247456-A | Water-insoluble monoazo pyridone dye | CASSELLA AKTIENGESELLSCHAFT (DE) | 1981-01-27 | — | — | US | disclosed |
| US-4201707-A | Methine dyestuffs containing a phenyl azo group | BAYER AKTIENGESELLSCHAFT (DE) | 1980-05-06 | — | — | US | disclosed |
| US-4156086-A | INTERMEDIATES FOR AZO DYES | BAYER AKTIENGESELLSCHAFT (DE) | 1979-05-22 | — | — | US | disclosed |
| US-4153413-A | DYEING POLYESTER OR CELLULOSE TRIACETATE WITH A DISPERSE AZO DYESTUFF, HEAT TREATMENT, PADDING, PRINTING | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-05-08 | — | — | US | disclosed |
| US-4138570-A | METHINE DYE | BAYER AKTIENGESELLSCHAFT (DE) | 1979-02-06 | — | — | US | disclosed |
| US-4038268-A | DIAZOTIZATION, COUPLING | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-26 | — | — | US | disclosed |
| US-4006128-A | CELLULOSE ACETATES, VINYL POLYMERS, POLYOLEFINS, POLYESTERS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-02-01 | — | — | US | disclosed |
| US-3957749-A | WATER-INSOLUBLE MONOAZO PYRIDINE DYES | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1976-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234377-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | HPGDS, PTGDR, PTGIS | HPGD 8/4885ALDH1A1 614/4885MAPT 4774/4885 |
| US-20260007768-A1 | CONJUGATION LINKERS | OGFR, SLC43A1, ILK | HPGD 3493/4885ALDH1A1 1312/4885MAPT 1475/4885 |
| US-12281060-B2 | Remodilins for airway remodeling and organ fibrosis | MYLK, MFAP1, FIBP | HPGD 2289/4885ALDH1A1 3220/4885MAPT 4699/4885 |
| US-20240415851-A1 | REMODILINS TO PREVENT OR TREAT CANCER METASTASIS, GLAUCOMA, AND HYPOXIA | HIF1AN, RHOXF2, HIF1A | HPGD 451/4885ALDH1A1 2857/4885MAPT 4394/4885 |
| US-12364771-B2 | Conjugation linkers | DNPEP, FGB, VIP | HPGD 2879/4885ALDH1A1 1899/4885MAPT 576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.