Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275316 | 0.80 | ALDH1A1 (0.44) | ALDH1A1MAPK1GPR84PARP1 | |
| SCHEMBL4356446 | 0.80 | ALDH1A1 (0.42) | ALDH1A1MAPK1GPR84PARP1GSK3B | |
| SCHEMBL13384270 | 0.79 | ALDH1A1 (0.39) | ALDH1A1MAPK1GPR84PARP1TYMP | |
| SCHEMBL9122617 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MAPK1GPR84PARP1GSK3B | |
| SCHEMBL27786276 | 0.78 | TYMP (0.37) | ALDH1A1MAPK1PARP1TYMPGSK3B | |
| SCHEMBL7626256 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MAPK1GPR84PARP1TYMP | |
| SCHEMBL14743462 | 0.76 | ALDH1A1 (0.44) | ALDH1A1MAPK1GPR84PARP1TYMP | |
| SCHEMBL27531476 | 0.75 | ALDH1A1 (0.41) | ALDH1A1MAPK1GPR84PARP1TYMP | |
| SCHEMBL225 | 0.75 | ALDH1A1 (0.41) | ALDH1A1MAPK1GPR84PARP1GSK3B | |
| SCHEMBL9081675 | 0.75 | GPR84 (0.45) | ALDH1A1MAPK1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885714-B1 | PROCESS FOR THE PREPARATION OF 2-ALKYL-1-((2'-SUBSTITUTED-BIPHENYL-4-YL)METHYL)-IMIDAZOLE, DIHYDROIMIDAZOLE OR BENZIMIDAZOLE DERIVATIVES | LEK PHARMACEUTICALS (SI) | 2014-01-15 | — | — | EP | claimed |
| US-20090176849-A1 | Process for the preparation of 2-alkyl-1-((2'-substituted-biphenyl-4-yl) Methyl)-imidazole, dihydroimidazole or benzimidazloe derivatives | LEK PHARMACEUTICALS, D.D. (SI) | 2009-07-09 | — | — | US | claimed |
| EP-1885714-A2 | PROCESS FOR THE PREPARATION OF 2-ALKYL-1-((2'-SUBSTITUTED-BIPHENYL-4-YL)METHYL)-IMIDAZOLE, DIHYDROIMIDAZOLE OR BENZIMIDAZOLE DERIVATIVES | LEK Pharmaceuticals D.D. (SI) | 2008-02-13 | — | — | EP | claimed |
| WO-2006125592-A2 | PROCESS FOR THE PREPARATION OF 2-ALKYL-1-((2'-SUBSTITUTED-BIPHENYL-4-YL)METHYL)-IMIDAZOLE, DIHYDROIMIDAZOLE OR BENZIMIDAZOLE DERIVATIVES | LEK PHARMACEUTICALS D.D. (SI) | 2006-11-30 | — | — | WO | claimed |
| US-20040147787-A1 | Process for oxidation of alcohols | MILLER ROSS A (US) | 2004-07-29 | — | — | US | claimed |
| WO-2003006435-A1 | PROCESS FOR OXIDATION OF ALCOHOLS | MERCK & CO., INC. (US) | 2003-01-23 | — | — | WO | claimed |
| EP-1885714-B1 | PROCESS FOR THE PREPARATION OF 2-ALKYL-1-((2'-SUBSTITUTED-BIPHENYL-4-YL)METHYL)-IMIDAZOLE, DIHYDROIMIDAZOLE OR BENZIMIDAZOLE DERIVATIVES | LEK PHARMACEUTICALS (SI) | 2014-01-15 | — | — | EP | disclosed |
| US-8293776-B2 | Compositions and methods for treating inflammatory conditions of the bowel | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-10-23 | — | — | US | disclosed |
| WO-2010017312-A1 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS OF THE BOWEL | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-02-11 | — | — | WO | disclosed |
| US-20100035852-A1 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS OF THE BOWEL | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-02-11 | — | — | US | disclosed |
| US-20090176849-A1 | Process for the preparation of 2-alkyl-1-((2'-substituted-biphenyl-4-yl) Methyl)-imidazole, dihydroimidazole or benzimidazloe derivatives | LEK PHARMACEUTICALS, D.D. (SI) | 2009-07-09 | — | — | US | disclosed |
| EP-1885714-A2 | PROCESS FOR THE PREPARATION OF 2-ALKYL-1-((2'-SUBSTITUTED-BIPHENYL-4-YL)METHYL)-IMIDAZOLE, DIHYDROIMIDAZOLE OR BENZIMIDAZOLE DERIVATIVES | LEK Pharmaceuticals D.D. (SI) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006125592-A2 | PROCESS FOR THE PREPARATION OF 2-ALKYL-1-((2'-SUBSTITUTED-BIPHENYL-4-YL)METHYL)-IMIDAZOLE, DIHYDROIMIDAZOLE OR BENZIMIDAZOLE DERIVATIVES | LEK PHARMACEUTICALS D.D. (SI) | 2006-11-30 | — | — | WO | disclosed |
| WO-2003006435-A1 | PROCESS FOR OXIDATION OF ALCOHOLS | MERCK & CO., INC. (US) | 2003-01-23 | — | — | WO | disclosed |
| EP-0540400-B1 | Quinoline derivatives, useful as angiotensin II antagonists | SYNTHELABO (FR) | 1995-08-23 | — | — | EP | disclosed |
| US-5432283-A | Substituted phenyl in 2 position; intermediates for drugs to treat hypertensive pathologies, cardiac, renal or pulmonary insufficiencies, and glaucoma | SYNTHELABO (FR) | 1995-07-11 | — | — | US | disclosed |
| US-5371227-A | Quinoline derivatives, process for their preparation, and their therapeutic applications | SYNTHELABO (FR) | 1994-12-06 | — | — | US | disclosed |
| US-5338740-A | Angiotensin II receptor antagonists | PFIZER INC. (US) | 1994-08-16 | — | — | US | disclosed |
| EP-0540400-A1 | Quinoline derivatives, useful as angiotensin II antagonists | SYNTHELABO (FR) | 1993-05-05 | — | — | EP | disclosed |
| EP-0429257-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-05-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147787-A1 | Process for oxidation of alcohols | TPO, ADH1C, GPX4 | ALDH1A1 68/4885MAPK1 2684/4885GPR84 3076/4885 |
| US-20090176849-A1 | Process for the preparation of 2-alkyl-1-((2'-substituted-biphenyl-4-yl) Methyl)-imidazole, dihydroimidazole or benzimidazloe derivatives | AGTR1, AGTR2, REN | ALDH1A1 790/4885MAPK1 509/4885GPR84 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.