Sugi Predict

Sugi Predict / Compounds / SCHEMBL3219019

SCHEMBL3219019

SCHEMBL3219019

CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1C(=O)Nc1ccc(CC#N)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 4/20 0.65
▸ EPHX1 P07099 1/20 0.43
▸ KMT2A Q03164 3/20 0.42
▸ SERPINE1 P05121 2/20 0.41
▸ MEN1 O00255 2/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ P2RX4 Q99571 1/20 0.39
▸ UBE2M P61081 1/20 0.39
▸ DCUN1D1 Q96GG9 1/20 0.39
▸ LMNA P02545 2/20 0.39
▸ MAPT P10636 2/20 0.39
▸ HTT P42858 2/20 0.39
▸ GAA P10253 1/20 0.39
▸ RECQL P46063 1/20 0.39
▸ NPSR1 Q6W5P4 1/20 0.39
▸ NPC1 O15118 3/20 0.38
▸ RAB9A P51151 2/20 0.38
▸ THRB P10828 1/20 0.38
▸ TRPV1 Q8NER1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL291054 1.00 TRPM8 (0.65) TRPM8EPHX1KMT2ASERPINE1MEN1
SCHEMBL31438756 1.00 TRPM8 (0.65) TRPM8EPHX1KMT2ASERPINE1MEN1
SCHEMBL16551709 1.00 TRPM8 (0.65) TRPM8EPHX1KMT2ASERPINE1MEN1
SCHEMBL4127806 1.00 TRPM8 (0.65) TRPM8EPHX1KMT2ASERPINE1MEN1
SCHEMBL16004827 1.00 TRPM8 (0.65) TRPM8EPHX1KMT2ASERPINE1MEN1
SCHEMBL584077 1.00 TRPM8 (0.65) TRPM8EPHX1KMT2ASERPINE1MEN1
SCHEMBL10044268 1.00 TRPM8 (0.65) TRPM8EPHX1KMT2ASERPINE1MEN1
SCHEMBL16551708 1.00 TRPM8 (0.65) TRPM8EPHX1KMT2ASERPINE1MEN1
SCHEMBL18812290 0.89 TRPM8 (0.62) TRPM8EPHX1KMT2ASERPINE1MEN1
SCHEMBL2628763 0.86 TRPM8 (0.70) TRPM8EPHX1KMT2ASERPINE1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250163006-A1 New Coolants, and Preparations Containing Same SYMRISE AG (DE) 2025-05-22 — — US claimed
US-20250066320-A1 Active Ingredients with Sialagogue and Tingling/Fizzy Effect, and Preparations Containing Same SYMRISE AG (DE) 2025-02-27 — — US claimed
EP-4469439-A1 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME Symrise AG (DE) 2024-12-04 — — EP claimed
CN-118984825-A Novel cooling agent and preparation containing same 西姆莱斯股份公司 2024-11-19 — — CN claimed
EP-4452941-A1 ACTIVE INGREDIENTS WITH SIALAGOGUE AND TINGLING/FIZZY EFFECT, AND PREPARATIONS CONTAINING SAME Symrise AG (DE) 2024-10-30 — — EP claimed
US-20240165004-A1 ORGANIC COMPOUNDS GIVAUDAN SA (CH) 2024-05-23 — — US claimed
US-20240058259-A1 COMPOSITIONS COMPRISING ESSENTIAL OILS FIRMENICH SA (CH) 2024-02-22 — — US claimed
EP-4304550-A1 ORGANIC COMPOUNDS Givaudan SA (CH) 2024-01-17 — — EP claimed
US-20240000746-A1 New Cooling Agents and Preparations Containing Them SYMRISE AG (DE) 2024-01-04 — — US claimed
EP-4247791-A2 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME Symrise AG (DE) 2023-09-27 — — EP claimed
WO-2022106452-A2 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2022-05-27 — — WO claimed
WO-2022105986-A1 NOVEL COOLING AGENTS AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2022-05-27 — — WO claimed
US-20200188289-A1 COMPOSITIONS COMPRISING ESSENTIAL OILS FIRMENICH SA (CH) 2020-06-18 — — US claimed
CN-110621287-A Composition comprising essential oils 弗门尼舍有限公司 2019-12-27 — — CN claimed
US-10392371-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2019-08-27 — — US claimed
EP-2318356-B1 SYNTHESIS OF CYCLOHEXANE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS PROCTER & GAMBLE (US) 2015-03-11 — — EP claimed
US-8426643-B2 Synthesis of cyclohexane derivatives useful as sensates in consumer products THE PROCTER & GAMBLE COMPANY (US) 2013-04-23 — — US claimed
US-8277824-B2 Solubilization of cyclohexane-based carboxamide derivatives for use as sensates in consumer products THE PROCTER & GAMBLE COMPANY (US) 2012-10-02 — — US claimed
US-20100076080-A1 Synthesis of Cyclohexane Derivatives Useful as Sensates in Consumer Products THE PROCTER & GAMBLE COMPANY 2010-03-25 — — US claimed
US-20100040563-A1 Solubilization of Cyclohexane-Based Carboxamide Derivatives for Use as Sensates in Consumer Products THE PROCTER & GAMBLE COMPANY 2010-02-18 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240165004-A1 ORGANIC COMPOUNDS TAS2R8, TAS2R10, TAS2R20 TRPM8 58/4885EPHX1 3262/4885KMT2A 2058/4885
US-20100040563-A1 Solubilization of Cyclohexane-Based Carboxamide Derivatives for Use as Sensates in Consumer Products CUTA, TAS2R8, TAS2R38 TRPM8 76/4885EPHX1 3890/4885KMT2A 3554/4885
US-10392371-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM4, TRPM6 TRPM8 1/4885EPHX1 4010/4885KMT2A 3630/4885
US-20250066320-A1 Active Ingredients with Sialagogue and Tingling/Fizzy Effect, and Preparations Containing Same TAS2R5, TAS2R7, TAS2R8 TRPM8 363/4885EPHX1 2617/4885KMT2A 2748/4885
US-20240000746-A1 New Cooling Agents and Preparations Containing Them TTPA, TREH, TAS2R45 TRPM8 132/4885EPHX1 1993/4885KMT2A 4030/4885
US-20250163006-A1 New Coolants, and Preparations Containing Same TTR, TAS2R5, TAS2R50 TRPM8 152/4885EPHX1 2081/4885KMT2A 3992/4885
US-20100076080-A1 Synthesis of Cyclohexane Derivatives Useful as Sensates in Consumer Products NISCH, TRPM4, TRPM8 TRPM8 3/4885EPHX1 528/4885KMT2A 1231/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.