Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GRK2 | P25098 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264987 | 1.00 | POLB (0.44) | POLBGRK2L3MBTL1APAF1DNMT1 | |
| SCHEMBL9287073 | 0.83 | FUCA1 (0.31) | POLBGRK2L3MBTL1APAF1DNMT1 | |
| SCHEMBL5415894 | 0.83 | APAF1 (0.31) | POLBGRK2L3MBTL1APAF1DNMT1 | |
| SCHEMBL5415901 | 0.83 | APAF1 (0.31) | POLBGRK2L3MBTL1APAF1DNMT1 | |
| SCHEMBL3264994 | 0.82 | APAF1 (0.31) | POLBGRK2L3MBTL1APAF1DNMT1 | |
| SCHEMBL28331514 | 0.73 | POLB (0.49) | POLBGRK2L3MBTL1APAF1DNMT1 | |
| SCHEMBL12234240 | 0.73 | SPHK1 (0.35) | POLBMEN1LMNAKMT2AFUCA1 | |
| SCHEMBL1577182 | 0.73 | SPHK1 (0.35) | POLBMEN1LMNAKMT2AFUCA1 | |
| SCHEMBL12593811 | 0.73 | SPHK1 (0.35) | POLBMEN1LMNAKMT2AFUCA1 | |
| SCHEMBL2735325 | 0.71 | GLS (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831012-A1 | METHOD OF CEMENTING IN A SUBTERRANEAN FORMATION USING CEMENT COMPOSITION COMPRISING LIGNITE - BASED GRAFTED COPOLYMERS | Halliburton Energy Services, Inc. (US) | 2015-02-04 | — | — | EP | claimed |
| WO-2013148976-A1 | METHOD OF CEMENTING IN A SUBTERRANEAN FORMATION USING CEMENT COMPOSITION COMPRISING LIGNITE - BASED GRAFTED COPOLYMERS | HALLIBURTON ENERGY SERVICES, INC. (US) | 2013-10-03 | — | — | WO | claimed |
| US-20100178260-A1 | COMPOSITION COMPRISING A RETINOID, AN ADENOSINE-BASED NONPHOSPHATED COMPOUND, AND A SEMICRYSTALLINE POLYMER | L'OREAL (FR) | 2010-07-15 | — | — | US | disclosed |
| WO-1995032356-A1 | ADDITIVES AND METHOD FOR CONTROLLING CLATHRATE HYDRATES IN FLUID SYSTEMS | COLORADO SCHOOL OF MINES (US) | 1995-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100178260-A1 | COMPOSITION COMPRISING A RETINOID, AN ADENOSINE-BASED NONPHOSPHATED COMPOUND, AND A SEMICRYSTALLINE POLYMER | RARA, RBP4, RBP1 | POLB 174/4885GRK2 3806/4885L3MBTL1 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.