Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 5/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27486960 | 0.77 | PAOX (0.35) | PAOX | |
| SCHEMBL11621725 | 0.77 | PAOX (0.35) | PAOXALDH1A1 | |
| SCHEMBL2178380 | 0.77 | PAOX (0.53) | PAOXLMNAALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL22771833 | 0.75 | PAOX (0.34) | PAOXPOLBMEN1KMT2ANPSR1 | |
| SCHEMBL27500557 | 0.75 | PAOX (0.34) | PAOXLMNATERTNPSR1 | |
| SCHEMBL27854645 | 0.73 | PAOX (0.41) | PAOXLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL3066861 | 0.73 | ALDH1A1 (0.52) | PAOXALDH1A1NPSR1 | |
| SCHEMBL2503661 | 0.73 | PAOX (0.33) | PAOX | |
| Iodomethane SCHEMBL11880494 | 0.73 | PAOX (0.50) | PAOXLMNAALDH1A1NFKB1KCNH2 | |
| SCHEMBL11668478 | 0.73 | LMNA (0.61) | PAOXLMNAALDH1A1TERTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3991963-A1 | MULTILAYER SHEET COMPRISING A FOAMED LAYER SUITABLE FOR FOOD PACKAGING | Borealis AG (AT) | 2022-05-04 | — | — | EP | disclosed |
| US-20100160626-A1 | Process For The Preparation Of 3,7-Dihydroxy-1,5-Diazacyclooctanes | ASTRAZENECA AB (SE) | 2010-06-24 | — | — | US | disclosed |
| EP-2014716-A1 | Polymer composition with high impact resistance and high melt strength | Borealis Technology Oy (FI) | 2009-01-14 | — | — | EP | disclosed |
| EP-2000504-A1 | Polymer composition with high impact resistance and high melt strength | Borealis Technology Oy (FI) | 2008-12-10 | — | — | EP | disclosed |
| US-20080200673-A1 | Process for The Preparation of Sulfonic Acid Salts of Oxabispidines | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | US | disclosed |
| US-20070197519-A1 | New Process For The Preparation Of Oxabispidines | ASTRAZENECA AB (SE) | 2007-08-23 | — | — | US | disclosed |
| US-7169921-B2 | Process for the preparation of oxabispidines | ASTRAZENECA AB (SE) | 2007-01-30 | — | — | US | disclosed |
| US-7012083-B2 | Compounds useful in therapy | PFIZER INC. (US) | 2006-03-14 | — | — | US | disclosed |
| US-20050014940-A1 | Process for the preparation of 2-or-9-oxa-3, 7-diazabicyclo (3.3.1) nonanes from 2-aminomethyl-2, 3-dihydrooxazines intermediates therefore, and processes for preparing such intermediates | ASTRAZENECA AB (SE) | 2005-01-20 | — | — | US | disclosed |
| EP-1385850-B1 | NEW PROCESS FOR THE PREPARATION OF OXABISPIDINES | ASTRAZENECA AB (SE) | 2004-12-08 | — | — | EP | disclosed |
| US-20040181060-A1 | Process for the preparation of oxabispidines | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | US | disclosed |
| US-6716834-B2 | ANTICOAGULANTS. | ASTRAZENECA AB (SE) | 2004-04-06 | — | — | US | disclosed |
| EP-1283837-B1 | NEW THIOCHROMANE DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | ASTRAZENECA AB (SE) | 2004-02-25 | — | — | EP | disclosed |
| US-20030220317-A1 | Thiochromane derivatives and their use as thrombin inhibitors | ASTRAZENECA AB (SE) | 2003-11-27 | — | — | US | disclosed |
| US-6479516-B1 | TREATMENT OF PRURITIC DERMATOSES INCLUDING ALLERGIC DERMATITIS AND ATOPY IN ANIMALS AND HUMANS | PFIZER INC | 2002-11-12 | — | — | US | disclosed |
| US-20020099214-A1 | Compounds useful in therapy | PFIZER INC. (US) | 2002-07-25 | — | — | US | disclosed |
| EP-1072594-A2 | 4-arylpiperidine derivatives for the treatment of pruritus | PFIZER INC. (US) | 2001-01-31 | — | — | EP | disclosed |
| EP-1072596-A2 | 4-arylpiperidine derivatives for the treatment of pruritus | PFIZER INC. (US) | 2001-01-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099214-A1 | Compounds useful in therapy | HRH2, ITCH, HRH4 | PAOX 1424/4885LMNA 4012/4885ALDH1A1 306/4885 |
| US-20030220317-A1 | Thiochromane derivatives and their use as thrombin inhibitors | SERPINC1, F2, TFPI | PAOX 4099/4885LMNA 3288/4885ALDH1A1 1261/4885 |
| US-20080200673-A1 | Process for The Preparation of Sulfonic Acid Salts of Oxabispidines | RPS3, RPS3A, STS | PAOX 2320/4885LMNA 3005/4885ALDH1A1 2238/4885 |
| US-20070197519-A1 | New Process For The Preparation Of Oxabispidines | TST, IDH3B, INTS6 | PAOX 1265/4885LMNA 3727/4885ALDH1A1 47/4885 |
| US-20040181060-A1 | Process for the preparation of oxabispidines | ADH1C, ADH1A, CYP2E1 | PAOX 1685/4885LMNA 2379/4885ALDH1A1 15/4885 |
| US-20050014940-A1 | Process for the preparation of 2-or-9-oxa-3, 7-diazabicyclo (3.3.1) nonanes from 2-aminomethyl-2, 3-dihydrooxazines intermediates therefore, and processes for preparing such intermediates | AOX1, DHODH, DHRS9 | PAOX 574/4885LMNA 1696/4885ALDH1A1 42/4885 |
| US-20100160626-A1 | Process For The Preparation Of 3,7-Dihydroxy-1,5-Diazacyclooctanes | CYP2D6, KCNH1, CYP2B6 | PAOX 2142/4885LMNA 502/4885ALDH1A1 259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.