Water

Water

SCHEMBL3359653

Nc1ccc(N(CCO)CCO)cc1.O

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 3/20 0.38
THRB known ✓ P10828 1/20 0.35
ALDH1A1 P00352 7/20 0.52
TDP1 Q9NUW8 7/20 0.52
CYP3A4 P08684 6/20 0.52
MAPK1 P28482 3/20 0.52
L3MBTL1 Q9Y468 3/20 0.52
TSHR P16473 3/20 0.52
GFER P55789 2/20 0.52
PSMD14 O00487 2/20 0.52
RECQL P46063 1/20 0.52
TP53 P04637 3/20 0.41
ALOX15 P16050 2/20 0.41
MAPT P10636 7/20 0.38
KDM4E B2RXH2 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
KMT2A Q03164 5/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28087334 0.98 ALDH1A1 (0.54) ALDH1A1TDP1CYP3A4MAPK1L3MBTL1
SCHEMBL8521178 0.98 ALDH1A1 (0.54) ALDH1A1TDP1CYP3A4MAPK1L3MBTL1
SCHEMBL33874 0.98 ALDH1A1 (0.54) ALDH1A1TDP1CYP3A4MAPK1L3MBTL1
Hydrochloric Acid SCHEMBL8756114 0.95 ALDH1A1 (0.52) ALDH1A1TDP1CYP3A4MAPK1L3MBTL1
SCHEMBL33796 0.95 ALDH1A1 (0.52) ALDH1A1TDP1CYP3A4MAPK1L3MBTL1
Hydrochloric Acid SCHEMBL7714474 0.95 ALDH1A1 (0.52) ALDH1A1TDP1CYP3A4MAPK1L3MBTL1
Hydrochloric Acid SCHEMBL9637634 0.93 ALDH1A1 (0.50) ALDH1A1TDP1CYP3A4MAPK1L3MBTL1
SCHEMBL14940571 0.91 ALDH1A1 (0.48) ALDH1A1TDP1CYP3A4MAPK1L3MBTL1
SCHEMBL34106 0.91 ALDH1A1 (0.48) ALDH1A1TDP1CYP3A4MAPK1L3MBTL1
Sulfuric Acid SCHEMBL3359652 0.90 ALDH1A1 (0.44) ALDH1A1TDP1CYP3A4MAPK1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230233431-A1 PRETREATMENT COMPOSITION OF A PROCESS FOR DYEING OR BLEACHING KERATIN FIBERS L'OREAL (FR) 2023-07-27 US disclosed
EP-3389622-B1 OXIDIZING COMPOSITION FOR TREATING KERATIN MATERIALS, COMPRISING A FATTY SUBSTANCE AND OXYALKYLENATED SURFACTANTS OREAL (FR) 2023-01-04 EP disclosed
EP-2841168-B1 DYEING PROCESS USING A MIXTURE COMPRISING A BRANCHED C6-C12 POLYOL, OBTAINED FROM AN AEROSOL DEVICE, AND DEVICE THEREFOR OREAL (FR) 2022-02-23 EP disclosed
EP-3544576-B1 DYE COMPOSITION COMPRISING 12-HYDROXYSTEARIC ACID, AN ORGANIC AMINE AND A DYE OREAL (FR) 2021-08-18 EP disclosed
EP-2515842-B1 DYEING COMPOSITION COMPRISING A POLYCONDENSATE OF ETHYLENE OXIDE AND PROPYLENE OXIDE OREAL (FR) 2020-04-29 EP disclosed
EP-2793802-B1 OXIDATION DYEING PROCESS USING A COMPOSITION RICH IN FATTY SUBSTANCES AND COMPRISING METAL CATALYSTS, AND DEVICE SUITABLE THEREFOR OREAL (FR) 2019-07-24 EP disclosed
EP-3233037-B1 DYE COMPOSITION COMPRISING A PARA-PHENYLENEDIAMINE OXIDATION BASE AND AN ADDITIONAL BASE OREAL (FR) 2019-04-10 EP disclosed
EP-3389622-A1 OXIDIZING COMPOSITION FOR TREATING KERATIN MATERIALS, COMPRISING A FATTY SUBSTANCE AND OXYALKYLENATED SURFACTANTS L'Oréal (FR) 2018-10-24 EP disclosed
EP-3233029-B1 DYE COMPOSITION COMPRISING A PARA-PHENYLENEDIAMINE OXIDATION BASE, A NONIONIC SURFACTANT IN A MEDIUM RICH IN FATTY SUBSTANCES OREAL (FR) 2018-09-19 EP disclosed
EP-3295924-A1 COMPOSITION FOR LIGHTENING OR DYEING KERATIN FIBERS WITH A LOW AMOUNT OF OXIDIZING AGENT The Procter and Gamble Company (US) 2018-03-21 EP disclosed
EP-2926802-B1 Hair colouring compositions, kits, method, and use thereof NOXELL CORP (US) 2017-09-27 EP disclosed
EP-2841046-B1 DYEING PROCESS USING A MIXTURE OBTAINED FROM AN AEROSOL DEVICE COMPRISING A NONIONIC FATTY AMIDE, AND DEVICE THEREFOR L'ORÉAL (FR) 2017-07-26 EP disclosed
WO-2017103260-A1 OXIDIZING COMPOSITION FOR TREATING KERATIN MATERIALS, COMPRISING A FATTY SUBSTANCE AND OXYALKYLENATED SURFACTANTS L'OREAL (FR) 2017-06-22 WO disclosed
EP-2846875-B1 DYEING PROCESS USING A MIXTURE OBTAINED FROM AN AEROSOL DEVICE COMPRISING A GLYCEROLATED OR AN OXYALKYLENATED CARBOXLIC ACID ETHER SURFACTANT, AND DEVICE THEREFOR L'ORÉAL (FR) 2017-06-14 EP disclosed
EP-2926802-A1 Hair colouring compositions, kits, method, and use thereof The Procter and Gamble Company (US) 2015-10-07 EP disclosed
EP-2198853-B1 Composition for the oxidative dyeing of keratinous fibres comprising a fatty material and N,N bis-(beta-hydroxyethyl)-paraphenylenediamine ORÉAL L (FR) 2015-08-12 EP disclosed
EP-2841046-A2 DYEING PROCESS USING A MIXTURE OBTAINED FROM AN AEROSOL DEVICE COMPRISING A NONIONIC FATTY AMIDE, AND DEVICE THEREFOR L'Oréal (FR) 2015-03-04 EP disclosed
WO-2013160260-A2 DYEING PROCESS USING A MIXTURE OBTAINED FROM AN AEROSOL DEVICE COMPRISING A NONIONIC FATTY AMIDE, AND DEVICE THEREFOR L'OREAL (FR) 2013-10-31 WO disclosed
EP-2198853-A1 Composition for the oxidative dyeing of keratinous fibres comprising a fatty material and N,N bis-(beta-hydroxyethyl)-paraphenylenediamine L'OREAL (FR) 2010-06-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230233431-A1 PRETREATMENT COMPOSITION OF A PROCESS FOR DYEING OR BLEACHING KERATIN FIBERS KRT18, COL1A1, CRYAB MEN1 4561/4885THRB 3864/4885ALDH1A1 500/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.