Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.34 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.32 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | GFER | P55789 | 2/20 | 0.52 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8756114 | 1.00 | ALDH1A1 (0.52) | ALDH1A1TDP1CYP3A4MAPK1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL9637634 | 0.98 | ALDH1A1 (0.50) | ALDH1A1TDP1CYP3A4MAPK1L3MBTL1 | |
| SCHEMBL8521178 | 0.98 | ALDH1A1 (0.54) | ALDH1A1TDP1CYP3A4MAPK1L3MBTL1 | |
| SCHEMBL28087334 | 0.98 | ALDH1A1 (0.54) | ALDH1A1TDP1CYP3A4MAPK1L3MBTL1 | |
| SCHEMBL33874 | 0.98 | ALDH1A1 (0.54) | ALDH1A1TDP1CYP3A4MAPK1L3MBTL1 | |
| SCHEMBL33796 | 0.95 | ALDH1A1 (0.52) | ALDH1A1TDP1CYP3A4MAPK1L3MBTL1 | |
| Water SCHEMBL3359653 | 0.95 | ALDH1A1 (0.52) | ALDH1A1TDP1CYP3A4MAPK1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL11701613 | 0.94 | ALDH1A1 (0.47) | ALDH1A1TDP1CYP3A4MAPK1L3MBTL1 | |
| SCHEMBL14940571 | 0.91 | ALDH1A1 (0.48) | ALDH1A1TDP1CYP3A4MAPK1L3MBTL1 | |
| SCHEMBL34106 | 0.91 | ALDH1A1 (0.48) | ALDH1A1TDP1CYP3A4MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634365-B1 | HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE | HENKEL AG & CO KGAA (DE) | 2022-08-10 | — | — | EP | claimed |
| EP-3496818-B1 | PROCESS FOR PREPARING HAIR DYE AGENTS HAVING UNILAMELLAR AND MULTILAMELLAR VESICLES | HENKEL AG & CO KGAA (DE) | 2021-01-20 | — | — | EP | claimed |
| US-10736827-B2 | Hair dye agent having unilamellar and multilamellar vesicles | HENKEL AG & CO. KGAA (DE) | 2020-08-11 | — | — | US | claimed |
| US-20200170904-A1 | HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE | HENKEL AG & CO. KGAA (DE) | 2020-06-04 | — | — | US | claimed |
| EP-3634365-A1 | HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE | Henkel AG & Co. KGaA (DE) | 2020-04-15 | — | — | EP | claimed |
| EP-3496818-A1 | HAIR DYE AGENT HAVING UNILAMELLAR AND MULTILAMELLAR VESICLES | Henkel AG & Co. KGaA (DE) | 2019-06-19 | — | — | EP | claimed |
| US-20190175459-A1 | HAIR DYE AGENT HAVING UNILAMELLAR AND MULTILAMELLAR VESICLES | HENKEL AG & CO. KGAA (DE) | 2019-06-13 | — | — | US | claimed |
| WO-2018224244-A1 | HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE | HENKEL AG & CO. KGAA (DE) | 2018-12-13 | — | — | WO | claimed |
| WO-2018028861-A1 | HAIR DYE AGENT HAVING UNILAMELLAR AND MULTILAMELLAR VESICLES | HENKEL AG & CO. KGAA (DE) | 2018-02-15 | — | — | WO | claimed |
| EP-3634365-B1 | HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE | HENKEL AG & CO KGAA (DE) | 2022-08-10 | — | — | EP | disclosed |
| EP-3496818-B1 | PROCESS FOR PREPARING HAIR DYE AGENTS HAVING UNILAMELLAR AND MULTILAMELLAR VESICLES | HENKEL AG & CO KGAA (DE) | 2021-01-20 | — | — | EP | disclosed |
| US-10736827-B2 | Hair dye agent having unilamellar and multilamellar vesicles | HENKEL AG & CO. KGAA (DE) | 2020-08-11 | — | — | US | disclosed |
| US-10702459-B2 | Hair dye having improved viscosity stability | HENKEL AG & CO. KGAA (DE) | 2020-07-07 | — | — | US | disclosed |
| US-20200170904-A1 | HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE | HENKEL AG & CO. KGAA (DE) | 2020-06-04 | — | — | US | disclosed |
| US-6371993-B1 | HAIR DYES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2002-04-16 | — | — | US | disclosed |
| EP-0621029-A1 | Use of metal salts and chelates together with chlorites as oxidants in hair coloring | Bristol-Myers Squibb Company (US) | 1994-10-26 | — | — | EP | disclosed |
| US-4196145-A | OXIDATION COLOR DYES | CLAIROL INCORPORATED (US) | 1980-04-01 | — | — | US | disclosed |
| US-4092102-A | HAIR DYES, OXIDATION DYES | CLAIROL INCORPORATED (US) | 1978-05-30 | — | — | US | disclosed |
| US-3981677-A | Oxidative hair dye compositions containing N-substituted o-phenylenediamines and method for their use | CLAIROL INCORPORATED (US) | 1976-09-21 | — | — | US | disclosed |
| US-3970423-A | PHENYLENEDIAMINE DERIVATIVES | CLAIROL INCORPORATED (US) | 1976-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10736827-B2 | Hair dye agent having unilamellar and multilamellar vesicles | EXOSC10, ANXA5, ANXA4 | GAA 4531/4885MAOA 1862/4885MAOB 1950/4885 |
| US-20200170904-A1 | HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE | UGCG, ADH1C, ELOVL1 | GAA 3840/4885MAOA 793/4885MAOB 776/4885 |
| US-10702459-B2 | Hair dye having improved viscosity stability | KRT18, S100B, SHH | GAA 4158/4885MAOA 517/4885MAOB 158/4885 |
| US-20190175459-A1 | HAIR DYE AGENT HAVING UNILAMELLAR AND MULTILAMELLAR VESICLES | EXOSC10, ANXA5, ANXA4 | GAA 4531/4885MAOA 1862/4885MAOB 1950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.