Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B known ✓ | Q07343 | 1/20 | 0.36 |
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.35 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.35 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.35 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.35 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 0.35 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 0.35 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080871 | 0.85 | ALDH1A1 (0.55) | ALDH1A1KDM4EKMT2AMEN1POLB | |
| SCHEMBL336185 | 0.73 | ALDH1A1 (0.40) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL21462437 | 0.70 | L3MBTL1 (0.45) | ALDH1A1KDM4EKMT2AMEN1POLB | |
| SCHEMBL11075024 | 0.69 | L3MBTL1 (0.49) | ALDH1A1KDM4EKMT2AMEN1POLB | |
| SCHEMBL9261071 | 0.69 | ALDH1A1 (0.54) | ALDH1A1KDM4EKMT2AMEN1POLB | |
| SCHEMBL337676 | 0.68 | ALDH1A1 (0.58) | ALDH1A1KDM4EKMT2AMEN1POLB | |
| SCHEMBL20568530 | 0.68 | ALDH1A1 (0.43) | ALDH1A1KDM4EKMT2AMEN1POLB | |
| SCHEMBL31434014 | 0.68 | MAPT (0.62) | ALDH1A1KDM4EKMT2APOLBL3MBTL1 | |
| SCHEMBL11076507 | 0.68 | L3MBTL1 (0.53) | ALDH1A1KDM4EKMT2AMEN1POLB | |
| SCHEMBL11639617 | 0.67 | ALDH1A1 (0.56) | ALDH1A1KDM4ETSHRGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142509-B1 | QUINOLONES AND AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE | AMGEN INC (US) | 2013-12-04 | — | — | EP | disclosed |
| US-8349868-B2 | Azaquinolones that inhibit prolyl hydroxylase | AMGEN INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-8097620-B2 | Diazaquinolones that inhibit prolyl hydroxylase activity | AMGEN INC. (US) | 2012-01-17 | — | — | US | disclosed |
| US-8048894-B2 | Quinolones and azaquinolones that inhibit prolyl hydroxylase | AMGEN INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-20110224248-A1 | AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE | AMGEN INC. (US) | 2011-09-15 | — | — | US | disclosed |
| EP-2155746-A2 | DIAZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | Amgen, Inc (US) | 2010-02-24 | — | — | EP | disclosed |
| EP-2142509-A2 | QUINOLONES AND AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE | Amgen, Inc (US) | 2010-01-13 | — | — | EP | disclosed |
| US-20090156605-A1 | Quinolones and azaquinolones that inhbit prolyl hydroxylase | AMGEN INC. (US) | 2009-06-18 | — | — | US | disclosed |
| US-20090099171-A1 | Diazaquinolones that inhibit prolyl hydroxylase activity | AMGEN INC. (US) | 2009-04-16 | — | — | US | disclosed |
| WO-2008137084-A2 | DIAZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008130600-A2 | QUINOLONES AND AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE | AMGEN INC. (US) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099171-A1 | Diazaquinolones that inhibit prolyl hydroxylase activity | EGLN3, EGLN2, HIF1AN | PDE4B 1045/4885GABRP 1324/4885GABRD 1622/4885 |
| US-20090156605-A1 | Quinolones and azaquinolones that inhbit prolyl hydroxylase | EGLN3, HIF1AN, EGLN2 | PDE4B 771/4885GABRP 1146/4885GABRD 2107/4885 |
| US-20110224248-A1 | AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE | HIF1AN, EGLN3, EGLN2 | PDE4B 749/4885GABRP 1652/4885GABRD 2227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.