Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL384819 | 0.97 | DNM1 (0.45) | DNM1MMP13TSHRALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL965472 | 0.93 | DNM1 (0.43) | DNM1MMP13TSHRALDH1A1LMNA | |
| Water SCHEMBL7551987 | 0.93 | DNM1 (0.43) | DNM1MMP13TSHRALDH1A1LMNA | |
| SCHEMBL10941450 | 0.93 | DNM1 (0.43) | DNM1MMP13TSHRALDH1A1LMNA | |
| SCHEMBL10947406 | 0.93 | DNM1 (0.43) | DNM1MMP13TSHRALDH1A1LMNA | |
| SCHEMBL10942066 | 0.93 | DNM1 (0.43) | DNM1MMP13TSHRALDH1A1LMNA | |
| Iodide SCHEMBL6383667 | 0.93 | DNM1 (0.43) | DNM1MMP13TSHRALDH1A1LMNA | |
| SCHEMBL14491205 | 0.90 | DNM1 (0.48) | DNM1MMP13TSHRLMNAFDPS | |
| SCHEMBL1904191 | 0.90 | DNM1 (0.48) | DNM1MMP13TSHRLMNAFDPS | |
| SCHEMBL3177291 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1477477-B1 | PROCESS FOR PREPARATION OF CAROTENOIDS | SUMITOMO CHEMICAL CO (JP) | 2010-12-22 | — | — | EP | disclosed |
| EP-1477477-A1 | PROCESS FOR PREPARATION OF CAROTENOIDS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-11-17 | — | — | EP | disclosed |
| US-6806387-B2 | A STARTING MATERIAL FOR VITAMIN A DERIVATIVES AND VARIOUS TERPENE COMPOUNDS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-10-19 | — | — | US | disclosed |
| US-20040204612-A1 | Process for preparation of carotenoids | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-10-14 | — | — | US | disclosed |
| EP-1199303-B1 | Process for producing retinol and intermediate compounds for producing the same | SUMITOMO CHEMICAL CO (JP) | 2004-09-22 | — | — | EP | disclosed |
| US-6784321-B2 | 1-((2-ARYLSULFONYL)(3-METHYL)(5-OXY)PENT-3-ENE)-2,6,6-TRIMETHY LCYCLOHEX-1-ENE DERIVATIVES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-08-31 | — | — | US | disclosed |
| EP-1426357-A1 | PROCESS FOR PREPARATION OF ALLYL SULFONE DERIVATIVES AND INTERMEDIATES FOR THE PREPARATION | Sumitomo Chemical Company, Limited (JP) | 2004-06-09 | — | — | EP | disclosed |
| US-20040082814-A1 | Process for producing retinol and intermediate compounds for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED | 2004-04-29 | — | — | US | disclosed |
| US-20040054233-A1 | Process for preparation of allyl sulfone derivatives and intermediates for the preparation | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-03-18 | — | — | US | disclosed |
| US-20040034257-A1 | Novel sulfone derivatives and process for producing these | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-02-19 | — | — | US | disclosed |
| US-20010025127-A1 | Dihalo-compound and process for producing vitamin A derivative | SUMITOMO CHEMICAL COMPANY, LTD. (JP) | 2001-09-27 | — | — | US | disclosed |
| EP-1120398-A2 | Dihalo-compound and process for producing vitamin A derivative | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-08-01 | — | — | EP | disclosed |
| US-6211411-B1 | SULFONE ALDEHYDE DERIVATIVES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-04-03 | — | — | US | disclosed |
| US-6172265-B1 | DRUG; FOOD OR FEED ADJUVANT; CHEMICAL INTERMEDIATE FOR CANTHAXANTHIN | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2001-01-09 | — | — | US | disclosed |
| US-6160181-A | Tetraene derivative and process for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |
| EP-0983998-A1 | Tetraene derivative and process for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2000-03-08 | — | — | EP | disclosed |
| EP-0900785-A2 | Vitamin A related compounds and process for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1999-03-10 | — | — | EP | disclosed |
| EP-0435014-B1 | Removal of organic cations from polar fluids | DOW CHEMICAL CO (US) | 1994-01-12 | — | — | EP | disclosed |
| EP-0435014-A1 | Removal of organic cations from polar fluids | THE DOW CHEMICAL COMPANY (US) | 1991-07-03 | — | — | EP | disclosed |
| US-4968433-A | Removal of organic cations from polar fluids | THE DOW CHEMICAL COMPANY (US) | 1990-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204612-A1 | Process for preparation of carotenoids | SCLY, RPS4Y1, ENY2 | DNM1 4827/4885MMP13 3291/4885TSHR 2760/4885 |
| US-20040082814-A1 | Process for producing retinol and intermediate compounds for producing the same | ADH4, ADH1B, ADH7 | DNM1 4704/4885MMP13 2456/4885TSHR 702/4885 |
| US-20040034257-A1 | Novel sulfone derivatives and process for producing these | RBP4, ADH4, RARB | DNM1 4881/4885MMP13 2857/4885TSHR 1488/4885 |
| US-20010025127-A1 | Dihalo-compound and process for producing vitamin A derivative | CYP2R1, CYP24A1, VDR | DNM1 4481/4885MMP13 3974/4885TSHR 684/4885 |
| US-20040054233-A1 | Process for preparation of allyl sulfone derivatives and intermediates for the preparation | ARSA, SULT1A1, SULT2A1 | DNM1 4700/4885MMP13 4350/4885TSHR 1267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.