SCHEMBL34716

SCHEMBL34716

COc1c(-c2ccc(O)c(O)c2)oc2cc(O)ccc2c1=O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.73
MEN1 O00255 3/20 0.73
MAPT P10636 3/20 0.73
KMT2A Q03164 3/20 0.73
HSD17B10 Q99714 3/20 0.73
APEX1 P27695 3/20 0.73
RECQL P46063 3/20 0.73
POLB P06746 2/20 0.73
POLH Q9Y253 2/20 0.73
GAA P10253 2/20 0.73
MMP1 P03956 1/20 0.73
HTT P42858 1/20 0.73
BLM P54132 1/20 0.73
CYP3A4 P08684 3/20 0.70
ALDH1A1 P00352 3/20 0.70
HPGD P15428 3/20 0.70
CDK5 Q00535 2/20 0.70
CDK5R1 Q15078 2/20 0.70
APP P05067 2/20 0.70
LMNA P02545 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29512814 1.00 KDM4E (0.73) KDM4EMEN1MAPTKMT2AHSD17B10
SCHEMBL14259678 0.88 TUBB4A (0.74) KDM4EMEN1MAPTKMT2AHSD17B10
SCHEMBL3282447 0.87 KDM4E (0.71) KDM4EMEN1MAPTKMT2AHSD17B10
SCHEMBL10860655 0.86 POLH (0.75) KDM4EMEN1MAPTKMT2AHSD17B10
SCHEMBL10335360 0.86 ABCB1 (0.80) KDM4EMEN1MAPTKMT2AHSD17B10
SCHEMBL7685641 0.85 MEN1 (0.64) KDM4EMEN1MAPTKMT2AHSD17B10
3-O-Methylquercetin SCHEMBL29897544 0.85 POLH (1.00) KDM4EMEN1MAPTKMT2AHSD17B10
3-O-Methylquercetin SCHEMBL380558 0.85 POLH (1.00) KDM4EMEN1MAPTKMT2AHSD17B10
SCHEMBL7685645 0.84 POLH (0.75) KDM4EMEN1MAPTKMT2AHSD17B10
SCHEMBL4286345 0.84 MEN1 (0.65) KDM4EMEN1MAPTKMT2AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130189383-A1 USE OF ACACIA EXTRACTS AND THEIR COMPOUNDS ON INHIBITION OF XANTHINE OXIDASE NATIONAL TAIWAN UNIVERSITY (TW) 2013-07-25 US claimed
US-8414936-B2 Use of Acacia extracts and their compounds on inhibition of xanthine oxidase NATIONAL TAIWAN UNIVERSITY (TW) 2013-04-09 US claimed
US-20120009288-A1 USE OF ACACIA EXTRACTS AND THEIR COMPOUNDS ON INHIBITION OF XANTHINE OXIDASE NATIONAL TAIWAN UNIVERSITY (TW) 2012-01-12 US claimed
US-20100310688-A1 ACACIA EXTRACTS AND THEIR COMPOUNDS ON INHIBITION OF XANTHINE OXIDASE NATIONAL TAIWAN UNIVERSITY (TW) 2010-12-09 US claimed
US-20090130051-A1 Flavonoid Compounds and Uses Thereof HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) 2009-05-21 US claimed
US-20250281560-A1 METHOD FOR PREVENTING AND/OR TREATING CANCER OR AUTOIMMUNE DISEASE WITH 3,4,2 Prime,3 Prime,4 Prime-PENTAHYDROXY-TRANS-CHALCONE NATIONAL CHUNG HSING UNIVERSITY (TW) 2025-09-11 US disclosed
EP-2999467-B1 USE OF A COMBINATION OF TWO COMPOUNDS FOR THE TREATMENT AND/OR PREVENTION OF BONE DISORDERS INST NAT DE LA RECH AGRONOMIQUE INRA (FR) 2020-01-08 EP disclosed
US-9833490-B1 Drug combination for the treatment of infertility and its preparation methods and applications SICHUAN SHANZE BIOTECH., LTD. (CN) 2017-12-05 US disclosed
US-8877260-B2 Use of acacia extracts and their compounds on inhibition of xanthine oxidase NATIONAL TAIWAN UNIVERSITY (TW) 2014-11-04 US disclosed
US-8877260-B2 Use of acacia extracts and their compounds on inhibition of xanthine oxidase NATIONAL TAIWAN UNIVERSITY (TW) 2014-11-04 US disclosed
US-20130189383-A1 USE OF ACACIA EXTRACTS AND THEIR COMPOUNDS ON INHIBITION OF XANTHINE OXIDASE NATIONAL TAIWAN UNIVERSITY (TW) 2013-07-25 US disclosed
US-20130189383-A1 USE OF ACACIA EXTRACTS AND THEIR COMPOUNDS ON INHIBITION OF XANTHINE OXIDASE NATIONAL TAIWAN UNIVERSITY (TW) 2013-07-25 US disclosed
US-8414936-B2 Use of Acacia extracts and their compounds on inhibition of xanthine oxidase NATIONAL TAIWAN UNIVERSITY (TW) 2013-04-09 US disclosed
US-8414936-B2 Use of Acacia extracts and their compounds on inhibition of xanthine oxidase NATIONAL TAIWAN UNIVERSITY (TW) 2013-04-09 US disclosed
US-20120009288-A1 USE OF ACACIA EXTRACTS AND THEIR COMPOUNDS ON INHIBITION OF XANTHINE OXIDASE NATIONAL TAIWAN UNIVERSITY (TW) 2012-01-12 US disclosed
US-20120009288-A1 USE OF ACACIA EXTRACTS AND THEIR COMPOUNDS ON INHIBITION OF XANTHINE OXIDASE NATIONAL TAIWAN UNIVERSITY (TW) 2012-01-12 US disclosed
US-20100310688-A1 ACACIA EXTRACTS AND THEIR COMPOUNDS ON INHIBITION OF XANTHINE OXIDASE NATIONAL TAIWAN UNIVERSITY (TW) 2010-12-09 US disclosed
US-20100310688-A1 ACACIA EXTRACTS AND THEIR COMPOUNDS ON INHIBITION OF XANTHINE OXIDASE NATIONAL TAIWAN UNIVERSITY (TW) 2010-12-09 US disclosed
US-20020147353-A1 Novel flavonoids VERENIGING CHRISTELIJK WETENSCHAPPELIJK ANDERWIJS (NL) 2002-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120009288-A1 USE OF ACACIA EXTRACTS AND THEIR COMPOUNDS ON INHIBITION OF XANTHINE OXIDASE XDH, AOX1, ACACA KDM4E 1981/4885MEN1 4855/4885MAPT 1479/4885
US-20020147353-A1 Novel flavonoids H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CBR1, ABCC8 KDM4E 3228/4885MEN1 2151/4885MAPT 4588/4885
US-20090130051-A1 Flavonoid Compounds and Uses Thereof CAT, NQO1, GPX4 KDM4E 4144/4885MEN1 4830/4885MAPT 3887/4885
US-20100310688-A1 ACACIA EXTRACTS AND THEIR COMPOUNDS ON INHIBITION OF XANTHINE OXIDASE XDH, ACACA, ACAT1 KDM4E 1895/4885MEN1 4854/4885MAPT 891/4885
US-20130189383-A1 USE OF ACACIA EXTRACTS AND THEIR COMPOUNDS ON INHIBITION OF XANTHINE OXIDASE XDH, AOX1, ACACA KDM4E 1981/4885MEN1 4855/4885MAPT 1479/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.