Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.39 |
| ▸ | PPARG | P37231 | 6/20 | 0.39 |
| ▸ | PPARD | Q03181 | 6/20 | 0.39 |
| ▸ | PPARA | Q07869 | 6/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TLR2 | O60603 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27823774 | 0.83 | GPR84 (0.41) | CES2GPR84FFAR1FFAR4 | |
| SCHEMBL11589986 | 0.82 | CES2 (0.37) | CES2GPR84PPARGPPARDPPARA | |
| SCHEMBL28891552 | 0.81 | FFAR3 (0.33) | TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL690093 | 0.80 | HSPD1 (0.44) | CES2GPR84PPARGPPARDPPARA | |
| SCHEMBL29218960 | 0.79 | GPR84 (0.42) | FDPSGPR84PPARDFFAR1FFAR4 | |
| SCHEMBL1716951 | 0.79 | HSPD1 (0.54) | GPR84PPARDMEN1KMT2AHSD17B10 | |
| SCHEMBL9954679 | 0.79 | GPR84 (0.42) | FDPSGPR84PPARDFFAR1FFAR4 | |
| SCHEMBL31212517 | 0.79 | GPR84 (0.42) | FDPSGPR84PPARDFFAR1FFAR4 | |
| SCHEMBL3388718 | 0.79 | GPR84 (0.38) | CES2GPR84PPARDFFAR1 | |
| SCHEMBL9955355 | 0.79 | GPR84 (0.42) | FDPSGPR84PPARDFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787448-B2 | Indolizino [3,2-C] quinoline-based fluorescent probe | SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) | 2020-09-29 | — | — | US | disclosed |
| US-10077225-B2 | Synthesis of intermediate for treprostinil production | UNITED THERAPEUTICS CORPORATION (US) | 2018-09-18 | — | — | US | disclosed |
| US-20170197898-A1 | SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION | UNITED THERAPEUTICS CORPORATION (US) | 2017-07-13 | — | — | US | disclosed |
| US-9611206-B2 | Synthesis of intermediate for treprostinil production | UNITED THERAPEUTICS CORPORATION (US) | 2017-04-04 | — | — | US | disclosed |
| US-9581601-B2 | Method of detection of amino acid sequence and/or identification of peptides and proteins, by use of a new derivatization reagent and synthesis of 5-formyl-benzene-1,3-disulphonic acid as derivatization reagent | RUDJER BOSKOVIC INSTITUTE (HR) | 2017-02-28 | — | — | US | disclosed |
| US-20160068461-A1 | SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION | UNITED THERAPEUTICS CORPORATION (US) | 2016-03-10 | — | — | US | disclosed |
| US-20150233937-A1 | METHOD OF DETECTION OF AMINO ACID SEQUENCE AND/OR IDENTIFICATION OF PEPTIDES AND PROTEINS, BY USE OF A NEW DERIVATIZATION REAGENT AND SYNTHESIS OF 5-FORMYL-BENZENE-1,3-DISULPHONIC ACID AS DERIVATIZATION REAGENT | RUDJER BOSKOVIC INSTITUTE (HR) | 2015-08-20 | — | — | US | disclosed |
| US-20130345471-A1 | SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION | UNITED THERAPEUTICS CORPORATION | 2013-12-26 | — | — | US | disclosed |
| US-8461393-B2 | Synthesis of intermediate for treprostinil production | UNITED THERAPEUTICS CORPORATION (US) | 2013-06-11 | — | — | US | disclosed |
| US-20120226076-A1 | SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION | UNITED THERAPEUTICS CORPORATION | 2012-09-06 | — | — | US | disclosed |
| US-7678787-B2 | Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists | WYETH (US) | 2010-03-16 | — | — | US | disclosed |
| US-7622612-B2 | Tricyclic derivatives and their use | CHEMTECH RESEARCH INCORPORATION (KR) | 2009-11-24 | — | — | US | disclosed |
| EP-1893615-A1 | PYRROLOBENZODIAZEPINE PYRIDINE CARBOXAMIDES AND DERIVATIVES AS FOLLICLE-STIMULATING HORMONE RECEPTOR ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-03-05 | — | — | EP | disclosed |
| US-20070021427-A1 | Novel tricyclic derivatives and their use | CHEMTECH RESEARCH INCORPORATION (KR) | 2007-01-25 | — | — | US | disclosed |
| US-20060287522-A1 | Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists | WYETH (US) | 2006-12-21 | — | — | US | disclosed |
| WO-2006135687-A1 | PYRROLOBENZODIAZEPINE PYRIDINE CARBOXAMIDES AND DERIVATIVES AS FOLLICLE-STIMULATING HORMONE RECEPTOR ANTAGONISTS | WYETH (US) | 2006-12-21 | — | — | WO | disclosed |
| US-20040038950-A1 | Pharmaceutical composition for treating IL-1 related diseases or disorders | METABOLIC ENGINEERING LABORATORIES CO., LTD. (KR) | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160068461-A1 | SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION | PTGIS, PTGES, TBXAS1 | SMPD1 672/4885CES2 1761/4885FDPS 37/4885 |
| US-20130345471-A1 | SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION | PTGIS, PTGES, TBXAS1 | SMPD1 672/4885CES2 1761/4885FDPS 37/4885 |
| US-20150233937-A1 | METHOD OF DETECTION OF AMINO ACID SEQUENCE AND/OR IDENTIFICATION OF PEPTIDES AND PROTEINS, BY USE OF A NEW DERIVATIZATION REAGENT AND SYNTHESIS OF 5-FORMYL-BENZENE-1,3-DISULPHONIC ACID AS DERIVATIZATION REAGENT | PTMS, FABP5, FPR1 | SMPD1 3431/4885CES2 3968/4885FDPS 168/4885 |
| US-20070021427-A1 | Novel tricyclic derivatives and their use | NFATC1, IL2, CCL2 | SMPD1 3835/4885CES2 2626/4885FDPS 1275/4885 |
| US-20040038950-A1 | Pharmaceutical composition for treating IL-1 related diseases or disorders | IL1R1, IL1A, IL1B | SMPD1 2230/4885CES2 3536/4885FDPS 3396/4885 |
| US-10077225-B2 | Synthesis of intermediate for treprostinil production | PTGIS, PTGES, TBXAS1 | SMPD1 672/4885CES2 1761/4885FDPS 37/4885 |
| US-20170197898-A1 | SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION | PTGIS, PTGES, TBXAS1 | SMPD1 672/4885CES2 1761/4885FDPS 37/4885 |
| US-10787448-B2 | Indolizino [3,2-C] quinoline-based fluorescent probe | DNA2, IRF3, DDB1 | SMPD1 4541/4885CES2 3432/4885FDPS 4447/4885 |
| US-20120226076-A1 | SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION | PTGIS, PTGES, TBXAS1 | SMPD1 672/4885CES2 1761/4885FDPS 37/4885 |
| US-20060287522-A1 | Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists | FSHR, GNRHR, PRLHR | SMPD1 3264/4885CES2 3886/4885FDPS 1342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.