Sugi Predict

Sugi Predict / Compounds / SCHEMBL356737

SCHEMBL356737

SCHEMBL356737

CC(C)(C)[Si](C)(C)Oc1cccc(N)c1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ CYP3A4 P08684 3/20 0.52
▸ ALDH1A1 P00352 2/20 0.52
▸ TP53 P04637 1/20 0.47
▸ MAOB P27338 2/20 0.46
▸ CA12 O43570 4/20 0.44
▸ CA1 P00915 4/20 0.44
▸ CA9 Q16790 4/20 0.44
▸ TSHR P16473 1/20 0.41
▸ HSP90AA1 P07900 2/20 0.41
▸ POLB P06746 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ CASP1 P29466 1/20 0.39
▸ RECQL P46063 1/20 0.39
▸ HSP90AB1 P08238 1/20 0.39
▸ APP P05067 1/20 0.37
▸ PREP P48147 2/20 0.36
▸ ATM Q13315 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7706827 0.86 CA1 (0.50) CYP3A4ALDH1A1TP53CA12CA1
SCHEMBL15472402 0.82 MAOB (0.54) CYP3A4TP53MAOBAPP
SCHEMBL3182564 0.81 CA12 (0.46) CYP3A4ALDH1A1MAOBCA12CA1
SCHEMBL17262435 0.80 CA12 (0.41) CYP3A4ALDH1A1CA12CA1CA9
SCHEMBL1099831 0.80 ALDH1A1 (0.59) CYP3A4ALDH1A1TP53MAOBCA12
SCHEMBL8904993 0.80 ALDH1A1 (0.59) CYP3A4ALDH1A1TP53MAOBCA12
SCHEMBL4004898 0.79 CYP3A4 (0.47) CYP3A4ALDH1A1CA12CA1CA9
SCHEMBL2329760 0.79 ACHE (0.50) ALDH1A1TP53CA12CA1CA9
SCHEMBL232409 0.79 CA12 (0.45) ALDH1A1MAOBCA12CA1CA9
SCHEMBL5292779 0.79 ACHE (0.45) CYP3A4ALDH1A1MAOBCA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117820159-A Synthesis method of 3,3' -dihydroxyazobenzene and hyperbranched azobenzene derived from same 河南省科学院高新技术研究中心 2024-04-05 — — CN claimed
WO-2025242903-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISEASES ONCO3R THERAPEUTICS BV (BE) 2025-11-27 — — WO disclosed
US-20250243188-A1 METHIONINE ADENOSYLTRANSERASE 2A INHIBITORS IDEAYA BIOSCIENCES, INC. 2025-07-31 — — US disclosed
CN-120136895-A 2, 8-Disubstituted quinazolines compound and preparation method and application thereof 暨南大学 2025-06-13 — — CN disclosed
US-12319676-B2 Substituted amide compounds useful as farnesoid X receptor modulators BRISTOL-MYERS SQUIBB COMPANY (US) 2025-06-03 — — US disclosed
CN-114436978-B Antifungal compound and application thereof 中国人民解放军海军军医大学 2024-06-18 — — CN disclosed
EP-3480193-B1 PYRAZOLE DERIVATIVES AS ALK5 INHIBITORS AND USES THEREOF HANMI PHARMACEUTICAL CO LTD (KR) 2024-05-29 — — EP disclosed
US-20240124400-A1 LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME DUKE UNIVERSITY (US) 2024-04-18 — — US disclosed
CN-117820159-A Synthesis method of 3,3' -dihydroxyazobenzene and hyperbranched azobenzene derived from same 河南省科学院高新技术研究中心 2024-04-05 — — CN disclosed
US-11814385-B2 Small molecule inhibitors targeting Clostridioides difficile sporulation UNIVERSITY OF SOUTH FLORIDA (US) 2023-11-14 — — US disclosed
EP-1979349-A2 ANTI-VIRAL COMPOUNDS Abbott Laboratories (US) 2008-10-15 — — EP disclosed
US-20070232645-A1 ANTI-VIRAL COMPOUNDS ABBVIE INC. 2007-10-04 — — US disclosed
WO-2007076035-A2 ANTI-VIRAL COMPOUNDS ABBOTT LABORATORIES (US) 2007-07-05 — — WO disclosed
EP-1761540-A1 QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA ICOS CORPORATION (US) 2007-03-14 — — EP disclosed
WO-2005113556-A1 QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA ICOS CORPORATION (US) 2005-12-01 — — WO disclosed
US-20050261284-A1 Diazinopyrimidines CHEN JIAN J 2005-11-24 — — US disclosed
US-6943158-B2 Diazinopyrimidines ROCHE PALO ALTO LLC (US) 2005-09-13 — — US disclosed
EP-1565475-A1 DIAZINOPYRIMIDINES F. HOFFMANN-LA ROCHE AG (CH) 2005-08-24 — — EP disclosed
WO-2004046152-A1 DIAZINOPYRIMIDINES F. HOFFMANN LA ROCHE AG (CH) 2004-06-03 — — WO disclosed
US-20040097493-A1 For preparing medicaments useful for the therapy of the p38 MAP kinase and FGFR kinase mediated diseases and conditions HOFFMANN-LA ROCHE INC. 2004-05-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12319676-B2 Substituted amide compounds useful as farnesoid X receptor modulators NR1H4, FXR1, NR1H3 CYP3A4 652/4885ALDH1A1 3644/4885TP53 2377/4885
US-20050261284-A1 Diazinopyrimidines MAPK6, MAPK1, MAP2K6 CYP3A4 2718/4885ALDH1A1 2233/4885TP53 2771/4885
US-20250243188-A1 METHIONINE ADENOSYLTRANSERASE 2A INHIBITORS MAT2A, MAT2B, MAT1A CYP3A4 1777/4885ALDH1A1 140/4885TP53 1217/4885
US-20240124400-A1 LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME CFH, LPAR3, CBR3 CYP3A4 2889/4885ALDH1A1 3931/4885TP53 2811/4885
US-20070232645-A1 ANTI-VIRAL COMPOUNDS HAVCR2, MAVS, EIF2AK2 CYP3A4 273/4885ALDH1A1 2723/4885TP53 465/4885
US-11814385-B2 Small molecule inhibitors targeting Clostridioides difficile sporulation SPOUT1, CLPP, RPN2 CYP3A4 2042/4885ALDH1A1 2083/4885TP53 2260/4885
US-20040097493-A1 For preparing medicaments useful for the therapy of the p38 MAP kinase and FGFR kinase mediated diseases and conditions FGFR1, MAPK1, FGF1 CYP3A4 4702/4885ALDH1A1 1646/4885TP53 1186/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.