SCHEMBL3610385

SCHEMBL3610385

Cc1cc(OC(F)(F)F)ccc1S(=O)(=O)Cl

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ FFAR4 Q5NUL3 2/20 0.46
▸ PDIA6 Q15084 1/20 0.41
▸ IDH1 O75874 2/20 0.40
▸ EPHX2 P34913 1/20 0.40
▸ GPR3 P46089 2/20 0.40
▸ KIF11 P52732 1/20 0.40
▸ CES1 P23141 1/20 0.40
▸ SMN1; SMN2 Q16637 2/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ CHRM5 P08912 2/20 0.38
▸ BCHE P06276 1/20 0.38
▸ ACHE P22303 1/20 0.38
▸ WDR5 P61964 1/20 0.37
▸ HRH4 Q9H3N8 1/20 0.37
▸ PKM P14618 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30540027 1.00 FFAR4 (0.46) FFAR4PDIA6IDH1EPHX2GPR3
SCHEMBL15212079 0.87 FFAR4 (0.46) FFAR4IDH1EPHX2GPR3KIF11
SCHEMBL6196375 0.83 PDIA6 (0.59) FFAR4PDIA6IDH1EPHX2GPR3
SCHEMBL29458350 0.83 PDIA6 (0.59) FFAR4PDIA6IDH1EPHX2GPR3
SCHEMBL30567116 0.81 GPR3 (0.41) FFAR4EPHX2GPR3KIF11CES1
SCHEMBL2437670 0.81 GPR3 (0.41) FFAR4EPHX2GPR3KIF11CES1
SCHEMBL1198803 0.81 TRPV4 (0.49) FFAR4GPR3KIF11CES1CHRM5
SCHEMBL29839101 0.81 PDIA6 (0.45) FFAR4PDIA6IDH1EPHX2GPR3
SCHEMBL2502219 0.81 TRPV4 (0.57) KIF11CES1CHRM5
SCHEMBL3691567 0.80 WDR5 (0.43) FFAR4GPR3KIF11CES1CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250152574-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. 2025-05-15 — — US disclosed
WO-2023154499-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. (US) 2023-08-17 — — WO disclosed
WO-2023154499-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. (US) 2023-08-17 — — WO disclosed
US-7718650-B2 Aryl sulfonamide compounds for treating obesity BIOVITRUM AB (SE) 2010-05-18 — — US disclosed
US-20100113435-A1 INHIBITORS OF 11-BETA-HYDROXY STERIOD DEHYDROGENASE TYPE 1 BIOVITRUM AB 2010-05-06 — — US disclosed
US-7618961-B2 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 BIOVITRUM AB (SE) 2009-11-17 — — US disclosed
US-7566715-B2 Substituted sulfonamide compounds useful for the prophylaxis and treatment of conditions relating to obesity, type II diabetes and/or disorders of the central nervous system BIOVITRUM AB (SE) 2009-07-28 — — US disclosed
US-20080096873-A1 NEW COMPOUNDS BIOVITRUM AB, A SWEDEN CORPORATION 2008-04-24 — — US disclosed
US-7319097-B2 Treatment of type II diabetes with benzenesulfonamide substituted with an N-heterocycle: N-[2-amino-5-(1,4-diazepan-1-yl)phenyl]benzenesulfonamide, N-[4-amino-5-(piperazinyl)phenyl]benzenesulfonamide, 3-amino-4-(5-methyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-N-phenyl-benzenesulfonamide hydrochloride BIOVITRUM AB (SE) 2008-01-15 — — US disclosed
US-7173035-B2 Arylsulfonamide compounds BIOVITRUM AB (SE) 2007-02-06 — — US disclosed
US-20060009446-A1 New compounds BIOVITRUM AB, A SWEDEN CORPORATION 2006-01-12 — — US disclosed
US-20050288275-A1 New compounds BIOVITRUM AB, A SWEDEN CORPORATION 2005-12-29 — — US disclosed
US-6969710-B2 Compounds BIOVITRUM AB (SE) 2005-11-29 — — US disclosed
US-20040224996-A1 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 BIOVITRUM AB (SE) 2004-11-11 — — US disclosed
EP-1406884-A1 ARYLSUSFONAMIDE COMPOUNDS FOR THE TREATMENT OF OBESITY, TYPE II DIABETES AND CNS-DISORDERS BIOVITRUM AB (SE) 2004-04-14 — — EP disclosed
US-20030149020-A1 New compounds PROXIMAGEN NEUROSCIENCE PLC (GB) 2003-08-07 — — US disclosed
US-20030149019-A1 New compounds PROXIMAGEN NEUROSCIENCE PLC (GB) 2003-08-07 — — US disclosed
EP-1283831-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 BIOVITRUM AB (SE) 2003-02-19 — — EP disclosed
WO-2002092585-A1 NOVEL, ARYLSUSFONAMIDE COMPOUNDS FOR THE TREATMENT OF OBESITY, TYPE II DIABETES AND CNS-DISORDERS BIOVITRUM AB (SE) 2002-11-21 — — WO disclosed
WO-2001090090-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 BIOVITRUM AB (SE) 2001-11-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030149020-A1 New compounds GPR119, SULT2A1, NAT1 FFAR4 192/4885PDIA6 1862/4885IDH1 2261/4885
US-20040224996-A1 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 HSD11B1, HSD17B1, HSD11B2 FFAR4 3338/4885PDIA6 2551/4885IDH1 246/4885
US-20030149019-A1 New compounds GPR119, SULT2A1, NAT1 FFAR4 192/4885PDIA6 1862/4885IDH1 2261/4885
US-20060009446-A1 New compounds GPR119, SULT2A1, STS FFAR4 201/4885PDIA6 1774/4885IDH1 2261/4885
US-20100113435-A1 INHIBITORS OF 11-BETA-HYDROXY STERIOD DEHYDROGENASE TYPE 1 HSD11B1, HSD17B1, HSD3B1 FFAR4 3228/4885PDIA6 2553/4885IDH1 382/4885
US-20080096873-A1 NEW COMPOUNDS GPR119, SULT2A1, STS FFAR4 201/4885PDIA6 1774/4885IDH1 2261/4885
US-20050288275-A1 New compounds GPR119, SULT2A1, STS FFAR4 201/4885PDIA6 1774/4885IDH1 2261/4885
US-20250152574-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF EBPL, EBP, CREBBP FFAR4 3999/4885PDIA6 1500/4885IDH1 3374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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