Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.69 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628648 | 1.00 | TRPM8 (0.69) | TRPM8EPHX1ALDH1A1EPHX2MEN1 | |
| SCHEMBL17559190 | 0.93 | TRPM8 (0.61) | TRPM8EPHX1ALDH1A1MEN1KMT2A | |
| SCHEMBL13989030 | 0.86 | TRPM8 (0.57) | TRPM8EPHX1ALDH1A1MEN1KMT2A | |
| SCHEMBL4149322 | 0.85 | TRPM8 (0.72) | TRPM8EPHX1MEN1NPC1RAB9A | |
| SCHEMBL3219019 | 0.85 | TRPM8 (0.65) | TRPM8EPHX1ALDH1A1MEN1NPC1 | |
| SCHEMBL584077 | 0.85 | TRPM8 (0.65) | TRPM8EPHX1ALDH1A1MEN1NPC1 | |
| SCHEMBL31438756 | 0.85 | TRPM8 (0.65) | TRPM8EPHX1ALDH1A1MEN1NPC1 | |
| SCHEMBL16004827 | 0.85 | TRPM8 (0.65) | TRPM8EPHX1ALDH1A1MEN1NPC1 | |
| SCHEMBL291054 | 0.85 | TRPM8 (0.65) | TRPM8EPHX1ALDH1A1MEN1NPC1 | |
| SCHEMBL16551708 | 0.85 | TRPM8 (0.65) | TRPM8EPHX1ALDH1A1MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 868 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118829416-A | Composition (III) | 西姆莱斯股份公司 | 2024-10-22 | — | — | CN | claimed |
| CN-117813077-A | Composition and method for producing the same | 西姆莱斯股份公司 | 2024-04-02 | — | — | CN | claimed |
| CN-117615798-A | Composition for combating malodour | 西姆莱斯股份公司 | 2024-02-27 | — | — | CN | claimed |
| EP-3081207-B1 | USE OF A LIPOSOME COMPOSITION | SYMRISE AG (DE) | 2022-09-21 | — | — | EP | claimed |
| US-10871363-B2 | Oral care composition with improved deposition efficacy of a cooling sensate agent in the oral cavity | THE PROCTER & GAMBLE COMPANY (US) | 2020-12-22 | — | — | US | claimed |
| EP-3687311-A1 | AMIDES FOR GENERATING A TRIGEMINAL EFFECT | Symrise AG (DE) | 2020-08-05 | — | — | EP | claimed |
| EP-3134081-B1 | CYCLOHEXANECARBOXAMIDE WITH COOLING PROPERTIES | PROCTER & GAMBLE (US) | 2020-04-22 | — | — | EP | claimed |
| EP-3142499-B1 | HOMOVANILLIC ACID ESTERS, IN PARTICULAR FOR ACHIEVING AN IMPRESSION OF HEAT AND/OR SPICINESS | SYMRISE AG (DE) | 2019-10-30 | — | — | EP | claimed |
| US-20190276389-A1 | SYNTHESIS OF ARYL CYCLOHEXANE ESTER DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | THE PROCTER & GAMBLE COMPANY | 2019-09-12 | — | — | US | claimed |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2019-08-27 | — | — | US | claimed |
| EP-2533760-A1 | LIQUID COMPOSITION COMPRISING A NON-MENTHOL COOLING AGENT AND A THICKENER FOR TREATING A RESPIRATORY SYMPTOM | The Procter & Gamble Company (US) | 2012-12-19 | — | — | EP | claimed |
| US-20120095042-A1 | Organic Compounds Having Cooling Properties | GIVAUDAN SA (CH) | 2012-04-19 | — | — | US | claimed |
| WO-2011100267-A1 | LIQUID COMPOSITION COMPRISING A NON-MENTHOL COOLING AGENT AND A THICKENER FOR TREATING A RESPIRATORY SYMPTOM | THE PROCTER & GAMBLE COMPANY (US) | 2011-08-18 | — | — | WO | claimed |
| US-20110195042-A1 | Compositions, Methods and Kits Useful for Treating a Respiratory Symptom | THE PROCTER & GAMBLE COMPANY | 2011-08-11 | — | — | US | claimed |
| US-20110182833-A1 | Carboxamide Derivatives Having Cooling Properties | GIVAUDAN SA (CH) | 2011-07-28 | — | — | US | claimed |
| WO-2011012421-A1 | A DENTIFRICE COMPOSITION COMPRISING POLYETHYLENEGLYCOL AND A COOLING AGENT | UNILEVER NV (NL) | 2011-02-03 | — | — | WO | claimed |
| EP-1685093-B1 | N-SUBSTITUTED P-MENTHANE CARBOSAMIDED | GIVAUDAN SA (CH) | 2010-04-14 | — | — | EP | claimed |
| US-20090240223-A1 | ABSORBENT ARTICLE COMPRISING LOTION COMPOSITION COMPRISING A COOLING AGENT | PROCTER & GAMBLE COMPANY, THE | 2009-09-24 | — | — | US | claimed |
| US-7414152-B2 | e. g. N-(4-cyanomethylphenyl) p-menthanecarboxamide; cooling agent in cosmetics and food industries; with additional cooling compound such as menthol, menthone, isopulegol | GIVAUDAN, SA (CH) | 2008-08-19 | — | — | US | claimed |
| US-20060276667-A1 | N-substituted p-menthane carboxamides | GIVAUDAN-SA | 2006-12-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195042-A1 | Compositions, Methods and Kits Useful for Treating a Respiratory Symptom | MUC1, TAS2R42, TAS2R7 | TRPM8 34/4885EPHX1 2455/4885ALDH1A1 4005/4885 |
| US-20060276667-A1 | N-substituted p-menthane carboxamides | ME2, ME3, PYM1 | TRPM8 45/4885EPHX1 268/4885ALDH1A1 2217/4885 |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM4, TRPM6 | TRPM8 1/4885EPHX1 4010/4885ALDH1A1 3726/4885 |
| US-20110182833-A1 | Carboxamide Derivatives Having Cooling Properties | CPS1, NQO2, NDUFA2 | TRPM8 376/4885EPHX1 3112/4885ALDH1A1 237/4885 |
| US-20120095042-A1 | Organic Compounds Having Cooling Properties | ME3, ME2, MSMO1 | TRPM8 361/4885EPHX1 1320/4885ALDH1A1 748/4885 |
| US-20190276389-A1 | SYNTHESIS OF ARYL CYCLOHEXANE ESTER DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | CUTA, TAS2R8, TRPA1 | TRPM8 39/4885EPHX1 1625/4885ALDH1A1 1425/4885 |
| US-10871363-B2 | Oral care composition with improved deposition efficacy of a cooling sensate agent in the oral cavity | ORAI1, TRPM4, TRPM7 | TRPM8 11/4885EPHX1 2061/4885ALDH1A1 3988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.