Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetosulfone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 4/20 | 0.44 |
| ▸ | CA2 known ✓ | P00918 | 4/20 | 0.44 |
| ▸ | CA12 known ✓ | O43570 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetosulfone SCHEMBL154571 | 0.89 | PKM (0.43) | PKMCYP2C19NPC1PRMT1KMT2A | |
| Acetosulfone SCHEMBL30205068 | 0.89 | PKM (0.43) | PKMCYP2C19NPC1PRMT1KMT2A | |
| Mono-N-Acetyl Dapsone SCHEMBL10920445 | 0.80 | PKM (1.00) | PKMCYP2C19NPC1GAAPRMT1 | |
| SCHEMBL9713853 | 0.79 | PKM (0.67) | PKMCYP2C19NPC1GAAPRMT1 | |
| SCHEMBL17779214 | 0.79 | PKM (0.70) | PKMCYP2C19NPC1GAAPRMT1 | |
| SCHEMBL9713935 | 0.77 | PKM (0.67) | PKMCYP2C19NPC1GAAPRMT1 | |
| SCHEMBL9713818 | 0.75 | PKM (0.63) | PKMCYP2C19NPC1GAAPRMT1 | |
| SCHEMBL9713813 | 0.74 | CDK1 (0.67) | PKMCYP2C19NPC1GAAKMT2A | |
| SCHEMBL9713865 | 0.74 | PKM (0.62) | PKMCYP2C19NPC1GAAKMT2A | |
| Acetosulfone SCHEMBL10697113 | 0.72 | TSHR (0.64) | PKMCYP2C19NPC1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7807803-B2 | Nucleic acid compositions for stimulating immune responses | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-7576066-B2 | Nucleic acid compositions for stimulating immune responses | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-20040152649-A1 | Nucleic acid compositions for stimulating immune responses | COLEY PHARMACEUTICAL GROUP, INC. | 2004-08-05 | — | — | US | disclosed |
| US-20040092472-A1 | Nucleic acid compositions for stimulating immune responses | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2004-05-13 | — | — | US | disclosed |