Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.67 |
| ▸ | CA1 | P00915 | 10/20 | 0.49 |
| ▸ | CA2 | P00918 | 10/20 | 0.49 |
| ▸ | CA9 | Q16790 | 7/20 | 0.49 |
| ▸ | CA12 | O43570 | 5/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14084895 | 0.85 | TRPM8 (0.70) | TRPM8EPHX1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL4817319 | 0.84 | TRPM8 (0.75) | TRPM8EPHX1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4820732 | 0.84 | TRPM8 (0.75) | TRPM8EPHX1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL2628672 | 0.84 | TRPM8 (0.75) | TRPM8EPHX1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL10073486 | 0.84 | TRPM8 (0.75) | TRPM8EPHX1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL2628645 | 0.83 | TRPM8 (0.70) | TRPM8EPHX1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL291318 | 0.83 | TRPM8 (0.70) | TRPM8EPHX1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL13989019 | 0.83 | TRPM8 (0.51) | TRPM8CA1CA2CA9CA12 | |
| SCHEMBL2628747 | 0.83 | TRPM8 (0.73) | TRPM8EPHX1SMN1; SMN2KMT2A | |
| SCHEMBL4819655 | 0.83 | TRPM8 (0.73) | TRPM8EPHX1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 263 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10871363-B2 | Oral care composition with improved deposition efficacy of a cooling sensate agent in the oral cavity | THE PROCTER & GAMBLE COMPANY (US) | 2020-12-22 | — | — | US | claimed |
| EP-3134081-B1 | CYCLOHEXANECARBOXAMIDE WITH COOLING PROPERTIES | PROCTER & GAMBLE (US) | 2020-04-22 | — | — | EP | claimed |
| US-20190276389-A1 | SYNTHESIS OF ARYL CYCLOHEXANE ESTER DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | THE PROCTER & GAMBLE COMPANY | 2019-09-12 | — | — | US | claimed |
| EP-3390352-A1 | SYNTHESIS OF CYCLOHEXANE ESTER DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | The Procter and Gamble Company (US) | 2018-10-24 | — | — | EP | claimed |
| WO-2017106279-A1 | SYNTHESIS OF CYCLOHEXANE ESTER DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | THE PROCTER & GAMBLE COMPANY (US) | 2017-06-22 | — | — | WO | claimed |
| US-20170119639-A1 | COMPOSITIONS FOR DEPOSITION ON BIOLOGICAL SURFACES | PROCTER & GAMBLE (US) | 2017-05-04 | — | — | US | claimed |
| EP-3134081-A2 | CYCLOHEXANECARBOXAMIDE WITH COOLING PROPERTIES | The Procter & Gamble Company (US) | 2017-03-01 | — | — | EP | claimed |
| WO-2016036423-A2 | COMPOSITIONS FOR DEPOSITION ON BIOLOGICAL SURFACES | THE PROCTER & GAMBLE COMPANY (US) | 2016-03-10 | — | — | WO | claimed |
| US-20150307447-A1 | COMPOSITIONS FOR DEPOSITION ON BIOLOGICAL SURFACES | THE PROCTER & GAMBLE COMPANY | 2015-10-29 | — | — | US | claimed |
| EP-2244745-B1 | ABSORBENT ARTICLE COMPRISING LOTION COMPOSITION COMPRISING A COOLING AGENT | PROCTER & GAMBLE (US) | 2015-03-25 | — | — | EP | claimed |
| US-RE44339-E1 | N-substituted P-menthane carboxamides | GIVAUDAN S.A. (CH) | 2013-07-02 | — | — | US | claimed |
| EP-2533760-A1 | LIQUID COMPOSITION COMPRISING A NON-MENTHOL COOLING AGENT AND A THICKENER FOR TREATING A RESPIRATORY SYMPTOM | The Procter & Gamble Company (US) | 2012-12-19 | — | — | EP | claimed |
| WO-2011100267-A1 | LIQUID COMPOSITION COMPRISING A NON-MENTHOL COOLING AGENT AND A THICKENER FOR TREATING A RESPIRATORY SYMPTOM | THE PROCTER & GAMBLE COMPANY (US) | 2011-08-18 | — | — | WO | claimed |
| US-20110195042-A1 | Compositions, Methods and Kits Useful for Treating a Respiratory Symptom | THE PROCTER & GAMBLE COMPANY | 2011-08-11 | — | — | US | claimed |
| WO-2011012421-A1 | A DENTIFRICE COMPOSITION COMPRISING POLYETHYLENEGLYCOL AND A COOLING AGENT | UNILEVER NV (NL) | 2011-02-03 | — | — | WO | claimed |
| EP-2244745-A2 | ABSORBENT ARTICLE COMPRISING LOTION COMPOSITION COMPRISING A COOLING AGENT | The Procter & Gamble Company (US) | 2010-11-03 | — | — | EP | claimed |
| US-20090240223-A1 | ABSORBENT ARTICLE COMPRISING LOTION COMPOSITION COMPRISING A COOLING AGENT | PROCTER & GAMBLE COMPANY, THE | 2009-09-24 | — | — | US | claimed |
| WO-2009105740-A2 | ABSORBENT ARTICLE COMPRISING LOTION COMPOSITION COMPRISING A COOLING AGENT | THE PROCTER & GAMBLE COMPANY (US) | 2009-08-27 | — | — | WO | claimed |
| US-7414152-B2 | e. g. N-(4-cyanomethylphenyl) p-menthanecarboxamide; cooling agent in cosmetics and food industries; with additional cooling compound such as menthol, menthone, isopulegol | GIVAUDAN, SA (CH) | 2008-08-19 | — | — | US | claimed |
| US-20060276667-A1 | N-substituted p-menthane carboxamides | GIVAUDAN-SA | 2006-12-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170119639-A1 | COMPOSITIONS FOR DEPOSITION ON BIOLOGICAL SURFACES | CUTA, TAS2R40, TAS2R20 | TRPM8 54/4885CA1 3289/4885CA2 2887/4885 |
| US-20110195042-A1 | Compositions, Methods and Kits Useful for Treating a Respiratory Symptom | MUC1, TAS2R42, TAS2R7 | TRPM8 34/4885CA1 620/4885CA2 381/4885 |
| US-20150307447-A1 | COMPOSITIONS FOR DEPOSITION ON BIOLOGICAL SURFACES | CUTA, TAS2R40, TAS2R20 | TRPM8 54/4885CA1 3289/4885CA2 2887/4885 |
| US-20060276667-A1 | N-substituted p-menthane carboxamides | ME2, ME3, PYM1 | TRPM8 45/4885CA1 899/4885CA2 498/4885 |
| US-20190276389-A1 | SYNTHESIS OF ARYL CYCLOHEXANE ESTER DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | CUTA, TAS2R8, TRPA1 | TRPM8 39/4885CA1 4540/4885CA2 3147/4885 |
| US-10871363-B2 | Oral care composition with improved deposition efficacy of a cooling sensate agent in the oral cavity | ORAI1, TRPM4, TRPM7 | TRPM8 11/4885CA1 96/4885CA2 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.