SCHEMBL3930136

SCHEMBL3930136

Oc1c(-c2ccccc2)n(F)c2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.47
CYP2C19 P33261 1/20 0.47
KMT2A Q03164 5/20 0.44
LMNA P02545 3/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
KDM4E B2RXH2 6/20 0.42
RCE1 Q9Y256 1/20 0.42
GAA P10253 1/20 0.40
ALDH1A1 P00352 8/20 0.39
HPGD P15428 3/20 0.39
AGTR1 P30556 2/20 0.39
POLB P06746 1/20 0.38
MAPT P10636 4/20 0.36
HTT P42858 3/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
ATM Q13315 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
IL1R1 P14778 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3935779 0.77 HSD17B10 (0.47) HSD17B10CYP2C19KMT2ALMNASMN1; SMN2
SCHEMBL5332174 0.75 KMT2A (0.67) HSD17B10CYP2C19KMT2ALMNASMN1; SMN2
SCHEMBL6820233 0.72 CYP19A1 (0.59) KMT2ASMN1; SMN2KDM4ERCE1GAA
SCHEMBL3628018 0.72 POLB (0.59) HSD17B10CYP2C19KMT2ALMNASMN1; SMN2
SCHEMBL11959493 0.71 GPR3 (0.55) CYP2C19KMT2AKDM4EGAAALDH1A1
SCHEMBL170977 0.70 AGTR1 (0.72) HSD17B10CYP2C19KMT2ALMNASMN1; SMN2
SCHEMBL6915948 0.70 KDM4E (0.43) HSD17B10CYP2C19KMT2ALMNAKDM4E
SCHEMBL3557485 0.69 AGTR1 (0.58) HSD17B10CYP2C19LMNASMN1; SMN2AGTR1
SCHEMBL30410617 0.68 ALDH1A1 (0.42) KMT2ASMN1; SMN2ALDH1A1HPGD
SCHEMBL28863436 0.68 ALDH1A1 (0.42) KMT2ASMN1; SMN2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7507835-B2 N-arylsulfonyl-3-aminoalkoxyindoles SUVEN LIFE SCIENCES LTD. (IN) 2009-03-24 US disclosed
US-20060173193-A1 N-arylsulfonyl-3-aminoalkoxyindoles SUVEN LIFE SCIENCES LIMITED (IN) 2006-08-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060173193-A1 N-arylsulfonyl-3-aminoalkoxyindoles HTR3C, HTR3A, AANAT HSD17B10 3722/4885CYP2C19 37/4885KMT2A 1753/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.