Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31257137 | 1.00 | TRPA1 (0.32) | TRPA1ATMESR1ESR2NPC1 | |
| SCHEMBL21401285 | 0.85 | ESR1 (0.35) | ESR1ESR2 | |
| SCHEMBL21294038 | 0.84 | ESR1 (0.35) | TRPA1ATMESR1ESR2NPC1 | |
| SCHEMBL10547082 | 0.82 | ALDH1A1 (0.30) | — | |
| SCHEMBL11049910 | 0.81 | ESR1 (0.38) | TRPA1ATMESR1ESR2NPC1 | |
| SCHEMBL25990577 | 0.81 | P2RX7 (0.33) | TRPA1ATMESR1ESR2NPC1 | |
| SCHEMBL31257139 | 0.81 | ESR1 (0.38) | TRPA1ATMESR1ESR2NPC1 | |
| SCHEMBL10550141 | 0.80 | NPC1 (0.33) | TRPA1ATMESR1ESR2NPC1 | |
| SCHEMBL10550138 | 0.80 | NPC1 (0.33) | TRPA1ATMESR1ESR2NPC1 | |
| SCHEMBL3709071 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0072615-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1985-12-27 | — | — | EP | claimed |
| US-4544664-A | Antihypertensive substituted imidazole derivatives | FARMOS GROUP, LTD. (FI) | 1985-10-01 | — | — | US | claimed |
| EP-0072615-A1 | Substituted imidazole derivatives and their preparation and use | Farmos Group Ltd. (FI) | 1983-02-23 | — | — | EP | claimed |
| EP-4055009-B1 | METHOD FOR PREPARING DEXMEDETOMIDINE | NORCHIM (FR) | 2023-10-11 | — | — | EP | disclosed |
| US-11718586-B2 | Method for preparing dexmedetomidine | NORCHIM (FR) | 2023-08-08 | — | — | US | disclosed |
| US-11718586-B2 | Method for preparing dexmedetomidine | NORCHIM (FR) | 2023-08-08 | — | — | US | disclosed |
| US-20190262314-A1 | READY-TO-USE DEXMEDETOMIDINE COMPOSITIONS | SLAYBACK PHARMA LLC | 2019-08-29 | — | — | US | disclosed |
| EP-2079706-B1 | METHOD FOR PREPARING MEDETOMIDINE AND ITS SALTS | GRINDEKS JSC (LV) | 2011-07-20 | — | — | EP | disclosed |
| US-7902377-B2 | Method for preparing medetomidine and its salts | JSC GRINDEKS (LV) | 2011-03-08 | — | — | US | disclosed |
| US-7902377-B2 | Method for preparing medetomidine and its salts | JSC GRINDEKS (LV) | 2011-03-08 | — | — | US | disclosed |
| US-20100048915-A1 | METHOD FOR PREPARING MEDETOMIDINE AND ITS SALTS. | GRINDEKS A JOINT STOCK COMPANY (LV) | 2010-02-25 | — | — | US | disclosed |
| US-20100048915-A1 | METHOD FOR PREPARING MEDETOMIDINE AND ITS SALTS. | GRINDEKS A JOINT STOCK COMPANY (LV) | 2010-02-25 | — | — | US | disclosed |
| WO-2009053709-A1 | PROCESS FOR THE PREPARATION OF MEDETOMIDINE | NORBROOK LABORATORIES LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |
| WO-2008055852-A1 | METHOD FOR PREPARING MEDETOMIDINE AND ITS SALTS | GRINDEKS, A JOINT STOCK COMPANY (LV) | 2008-05-15 | — | — | WO | disclosed |
| EP-1918282-A1 | Method for preparing medetomidine and its salts | "Joint Stock Company Grindeks" (LV) | 2008-05-07 | — | — | EP | disclosed |
| US-4826864-A | Substituted imidazole derivatives useful as antihypertensive or antithromtic agent or divretic | FARMOS GROUP LTD. (FI) | 1989-05-02 | — | — | US | disclosed |
| US-4639464-A | Antihypertensive substituted imidazole derivatives | FARMOS GROUP, LTD. (FI) | 1987-01-27 | — | — | US | disclosed |
| EP-0072615-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1985-12-27 | — | — | EP | disclosed |
| US-4544664-A | Antihypertensive substituted imidazole derivatives | FARMOS GROUP, LTD. (FI) | 1985-10-01 | — | — | US | disclosed |
| EP-0072615-A1 | Substituted imidazole derivatives and their preparation and use | Farmos Group Ltd. (FI) | 1983-02-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718586-B2 | Method for preparing dexmedetomidine | ADH1C, ADH1A, ADH5 | TRPA1 4517/4885ATM 4147/4885ESR1 4749/4885 |
| US-20100048915-A1 | METHOD FOR PREPARING MEDETOMIDINE AND ITS SALTS. | ADRB2, ADRB3, OPRM1 | TRPA1 1587/4885ATM 3837/4885ESR1 3311/4885 |
| US-20190262314-A1 | READY-TO-USE DEXMEDETOMIDINE COMPOSITIONS | OPRD1, OPRM1, DRD2 | TRPA1 976/4885ATM 4639/4885ESR1 3987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.